Protein Alignment sti and gek

DIOPT Version :9

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Alignment Length: 2006
• Identity: 450/2006 - (22%)
• Similarity: 749/2006 - (37%)
• Gaps: 717/2006 - (35%)

  Fly    66 LLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLV 130
            |||.|.:||:||...:| :|::.:::|:...:|.:...||||::.|||.|..:||:|.||.|.:|
  Fly    54 LLDTFIVLYDECSNSSL-RREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVV 117

  Fly   131 VERQTNDIYAMKKIKK----SVVTTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPG 191
            ....|..:||||.:.|    ....|:..:||||::...:.:|:.||.||||||.||||||:|..|
  Fly   118 QMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCG 182

  Fly   192 GDLLSLMSR-HGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAA 255
            ||||:|:|: .....||:|:||:.|:.:|::::|::.||||||||:|:|:|:.||::|||||:..
  Fly   183 GDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCL 247

  Fly   256 ALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRI-VSCDYWSMGIIGYELICETTP 319
            .||:||.|.|...|||||||:||:|:.:...|        .|. ..||:||:|:..||::...||
  Fly   248 RLDKDGTVQSNVAVGTPDYISPEILRAMEDGK--------GRYGTECDWWSLGVCMYEMLYGETP 304

  Fly   320 FHEDNVHETYSKILSH--CEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRLSYERIK---N 379
            |:.:::.|||.||::|  |.....:|.:::    |||...::|:..|:..|..||....|:   :
  Fly   305 FYAESLVETYGKIMNHQNCFNLPSQETLNY----KVSETSQDLLCKLICIPENRLGQNGIQDFMD 365

  Fly   380 HPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNF---EDGIRHKTRREQGVAKKSLTTNMKSN---D 438
            ||:|..|.|.:||....|.:|.|.|..|||||   ::.:|             ||.::..:   .
  Fly   366 HPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVR-------------LTDSIPPSANPA 417

  Fly   439 FSGKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKTD 503
            |||..|||||::|     |..|::|              |.:::|:.|....|.|       .|.
  Fly   418 FSGFHLPFIGFTF-----SLTSSST--------------LDSKKNQSSGFGDDTL-------DTI 456

  Fly   504 NKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQK 568
            :..|:.            |:.....|......|:|.|..
  Fly   457 SSPQLA------------ILPSNNSETPVDSVQLKALND-------------------------- 483

  Fly   569 YEEAKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQQIKEQN 633
                          |||..|||.|. |.|      :.|..||..|....:||:      .|.::|
  Fly   484 --------------QLAALKQEKAE-LSK------QHNEVFERLKTQDSELQD------AISQRN 521

  Fly   634 LKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQEAKN 698
            : :...:.|...:::||..|| ..|.::|||.::              |||.::..:.|.:....
  Fly   522 I-AMMEYSEVTEKLSELRNQK-QKLSRQVRDKEE--------------ELDGAMQKNDSLRNELR 570

  Fly   699 ATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAE--CHRLERELQLAECRCQ 761
            .:::...|:            |||.|...:|.   .||.:.:| .||  |.:|:.||:......:
  Fly   571 KSDKTRREL------------ELHIEDAVIEA---AKEKKLRE-HAEDCCRQLQMELRKGSSSVE 619

  Fly   762 LA-ESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQMLER 825
            .. ..|:::::|.|        |:..:|       |...|..:||:.|.:.      :||.:.|:
  Fly   620 TTMPLSISSEMSSY--------EIERLE-------LQFSEKLSHQQTRHNM------ELEALREQ 663

  Fly   826 FNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAARTANLSLWKVEKQL 890
            |:|                             ||:                  |||:|.|
  Fly   664 FSE-----------------------------LEN------------------ANLALTK----- 676

  Fly   891 EEALSEKKLLARRMELTEDRIK--KVQNASDEAQRMLKTSQEETRQRESRIEELKQELAAAKRDV 953
                        .::.|::|:|  ::::.:|.|:.:|:..::...::.|..|| ||.|::
  Fly   677 ------------ELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEE-KQRLSS----- 723

  Fly   954 LKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQK-LRQIQSRFDGVTLEQKNTIRELQ 1017
                                              |..|:.| |:::|:..|.:       .:||:
  Fly   724 ----------------------------------EVNLKSKSLKELQAEDDEI-------FKELR 747

  Fly  1018 EEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETMLKSEQERNKSQKSQLDTL 1082
            .:||                            |.::.:.|:.|:...:..|    |..:..|..|
  Fly   748 MKRE----------------------------AITLWERQMAEIIQWVSDE----KDARGYLQAL 780

  Fly  1083 HEKLRERNDQLTDLRKQLTTVES----EKRLAEQRAQVLASEIDELR-LNLKEQQKKLVAQQDQL 1142
            ..|:.|..:.|    |.:.|..:    .|....:|:|    ::|::. |||:...::.:..::.:
  Fly   781 ATKMTEELEYL----KHVGTFNNNGVDNKNWRNRRSQ----KLDKMELLNLQSALQREIQAKNMI 837

  Fly  1143 VEQTNALFATQERAELLDGQNANYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAEIRG 1207
            .::     .:|.|::|:..|            :|:...|:....||.:...|:.|:.:||.  .|
  Fly   838 SDE-----LSQTRSDLISTQ------------KEVRDYKKRYDSILHDFQKKETELRDLQK--GG 883

  Fly  1208 LESAQANL----HAEIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKT 1268
            ||.:::.|    |..:.|         .|:  ||:..|:      ::||         ||:.
  Fly   884 LEYSESFLNKSTHHGLSS---------AFF--RDMSKNS------EIID---------SAES--- 919

  Fly  1269 LADKLFGSSHTNKENVSPNDVESSILYRALKEELKREQKMNSLLKEQLAQLNGTATLRSPRKSAA 1333
                 ||:.  :.:|.:||..:|.                ||          |......|:.:..
  Fly   920 -----FGNE--SGDNFTPNFFQSG----------------NS----------GMLFNYEPKYAGK 951

  Fly  1334 VNGDSDAPKQRPVSIAALPRSPQKQQQPLKRTTSQVELKTTAEKPTKVTIENQAHHRFELALQES 1398
            .|.|..:.|:..||..:...|.|..::..|:...                 |.|.|:|.:....|
  Fly   952 NNKDHSSMKEASVSDLSREESDQLVKESQKKVPG-----------------NTAIHQFLVRTFSS 999

  Fly  1399 KVDAVNCV-----VCEKAVVAGSPFWKCKECKDVTHRKCRSNVQSHC----GSTK------PT-- 1446
            .....:|.     :..:.||       |:.|....|..|...|.:.|    ..||      ||
  Fly  1000 PTKCNHCTSLMVGLTRQGVV-------CEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRG 1057

  Fly  1447 ----------APS-------------------------ADDLSSIQSVS-SLTLDSVD------- 1468
                      .|.                         :.|..::.||| |..||..|
  Fly  1058 IGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGS 1122

  Fly  1469 -------------------VAGGTTSGGEYIGSLVYSSDGAEDQ-------------ARKEIEVN 1501
                               :......||..:.:|:.:.:.:|..             .|..:...
  Fly  1123 VRESDVIHAAKKDVPCIFKIKTALIDGGLSLNTLMLADNESEKSKWVIALGELHRILKRNSLPNT 1187

  Fly  1502 CAFEVAE--------------------QQILLLGCNTGLYAYHLDSQRLVHISGLESVSCMSICK 1546
            ..|:|.|                    .|| |||...||:..:||...:..|.  ||...:.:..
  Fly  1188 AIFKVNEILDNTLSLIRNALCSVIIYPNQI-LLGTEDGLFYINLDQYEIARIG--ESKKILQLWY 1249

  Fly  1547 RLAKAIMVGTVGEKLYQCDYRQLESRCQSSSSCHKPVLETSAIELPFANRTPSEKWKLVLISDEA 1611
            ...:.|:|...|:   |.:.|.|..|          .||.|.:|           |..|:   |:
  Fly  1250 IEEEQILVILCGK---QRNLRLLPIR----------ALEASDVE-----------WIKVV---ES 1287

  Fly  1612 ENALDSVAIAATSTRIVILKYDLKLHMFKPVRALDTATPVTSIFFTRHSAIVSSDKFYEIDLD-- 1674
            :|.:.  |......|...:.|...:.:.:|               ..|:.||    .|||:..
  Fly  1288 KNCIS--ACTGIIRRFPNIVYSFIIALKRP---------------NNHTQIV----VYEINRTRT 1331

  Fly  1675 ----------NYAAEEFVDLSDKSM---------------ESTAK---------CQPLT-----A 1700
                      .|.|:....|||..:               |:||.         |..|.     |
  Fly  1332 RHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCAFLNYSGVDA 1396

  Fly  1701 VRI---------SRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTGFVYRDPFLFISHYQSVQ 1756
            ||:         :..||||.|....::||..|.:||..::.:...||...:.|..|.:.....:.
  Fly  1397 VRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLD 1461

  Fly  1757 IVRLHRSFSKEMASGDNASENSESPE-LQRVYLPHYMSTLLANSGDVNLYAVAIDQRPCNGTQKI 1820
            |.                  |:::.| :|.:.|.  .|..|.|.|:|.|.:|       |.|..|
  Fly  1462 IF------------------NTQTAEWVQSIGLK--QSLPLNNLGNVVLSSV-------NDTPLI 1499

  Fly  1821 YHLDT----------------MQAFKQKFNIS--METLSSVATSVTLGSTVTGNSI 1858
            .:|..                :.:.|::|:|.  .:|:.|...|..:.:....|.|
  Fly  1500 VYLSNIHTKGLLQYRDGNRKGLPSIKRRFSIREINKTIKSDRRSKMISAPTNFNHI 1555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	143/357 (40%)
		S_TKc	113..383	CDD:214567	116/280 (41%)
		Smc	487..1222	CDD:224117	134/749 (18%)
		CNH	1503..1774	CDD:279162	68/340 (20%)
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	143/356 (40%)
		S_TKc	100..369	CDD:214567	116/280 (41%)
		KELK	478..556	CDD:292424	29/146 (20%)
		CEP63	492..749	CDD:293650	81/433 (19%)
		CEP63	652..880	CDD:293650	64/401 (16%)
		C1_1	990..1040	CDD:278556	11/56 (20%)
		PH_MRCK	1049..1182	CDD:269949	15/132 (11%)
		CNH	1211..1486	CDD:279162	72/345 (21%)
		CRIB	1544..1580	CDD:238077	2/12 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442196
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D6806at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22988
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850