DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and rock2b

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_021324031.1	Gene:	rock2b / 321070	ZFINID:	ZDB-GENE-060125-2	Length:	1493	Species:	Danio rerio

Alignment Length:	1774	Identity:	428/1774 - (24%)
Similarity:	743/1774 - (41%)	Gaps:	467/1774 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVH 128
            |.|||:...|..:.:...|:| ::||..|::::...:...::|:|..|||....|||:|.||.|.
Zfish    30 ESLLDSVTALALDLNHPALRK-NKNIDAFLSRYEKAVCNLKELQVKLDDFDRVKLIGRGAFGAVQ 93

  Fly   129 LVVERQTNDIYAMKKIKK-SVVTTSQVK---EERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYM 189
            ||..:.:..:||||::.| .:|..|...   ||||||:...|.|::.|..||||...||||||:|
Zfish    94 LVRHKVSQQVYAMKQLSKFEMVKRSDSAFFWEERDIMAFSQSPWIVQLCCAFQDEKYLYLVMEFM 158

  Fly   190 PGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNA 254
            |||||::|.|.: ...|:.|:||.||:.:||..:|.:|::||||||:|:|:||.||:||||||..
Zfish   159 PGGDLVTLTSNY-DIPEEWAQFYTAEVVLALDAIHSLGFIHRDIKPDNMLLDRNGHLKLADFGTC 222

  Fly   255 AALDRDGHVLSLSPVGTPDYIAPELLQTI-STYKLSKSMHDVSRIVSCDYWSMGIIGYELICETT 318
            ..:|..|.|...:.|||||||:||:|.:. .|....:         .||:||:|:..|||:...|
Zfish   223 MKMDSTGMVRCDTAVGTPDYISPEVLMSQGGTGYYGR---------ECDWWSVGVFIYELLVGDT 278

  Fly   319 PFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRL---SYERIKNH 380
            ||:.:::..||.||:.|      |..::||.|:::|.|.::||.:.:::...||   ..:.||.|
Zfish   279 PFYSESLVGTYGKIMDH------KNSLTFPDDIEMSKNAKDLICAFLSSREVRLGRTGVDEIKCH 337

  Fly   381 PFFSEIPW--GSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSNDFSGKD 443
            |||....|  .:||..:.|::|.:.||.|||||:|.|     ::..:..:   |......|:|..
Zfish   338 PFFKNDQWTFDTIRDTMAPVVPELSSDIDTSNFDDDI-----KDDPIGTE---TFPPPRAFAGNQ 394

  Fly   444 LPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKTDNKSQV 508
            |||:|:::...:                     :|.|::|:.|  ::|::. ...|..|::.
Zfish   395 LPFVGFTYFRED---------------------QLLTQQNKCS--EEDIIE-DHGLNHTESN--- 432

  Fly   509 VADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQKYEEAK 573
              |.:..:|||::                       |...||.:|:|..            .:.:
Zfish   433 --DLEKRLKKLEE-----------------------KFKHEMQAKEELE------------NKCR 460

  Fly   574 IASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQQIKEQNLKSET 638
            ||: ||.||...|.::|:              ||: :|.:.....|:..|.:|:..:.|:::...
Zfish   461 IAN-QRLEKLSKDLEEEV--------------NAR-QEAEDNLRSLEKEKVLLKHQRTQSVRKAG 509

  Fly   639 NHEEQRR----QMAELYEQKLTDLRKKVRDSQ---DTNRRMTMEIKEI----RTELDESISSSKS 692
            ...:::|    :::.|.|| |.:|:||.:.|.   :.|..:..:::|:    :.||:||....|:
Zfish   510 LETDRKRLLENEVSSLKEQ-LAELKKKNQISHLSAEKNIHLERQLEEVSAKLQAELEESERLKKA 573

  Fly   693 TQEAKNATERNIEEILRRLNEEIA----SNNELHAEKVKLETKLQLKENETQ-------EVRAEC 746
            ..||...::: :|..||.|.|.:|    |...|..:|:.|:|.|:|::.|..       :::...
Zfish   574 QIEAFRQSQQ-LELSLRELQERLAQLENSRLVLEQDKLSLQTSLELEKRERNAGSETITDLQGRI 637

  Fly   747 HRLERELQLAECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQ 811
            :.||.||:..:                     .||::....:.||:.||...::.:|.|:   ..
Zfish   638 YGLEGELKHIK---------------------SSLSKAEVEKRQLQEDLTTLEKEKNKQE---ID 678

  Fly   812 LQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAA 876
            |...:..::|.|    ||..:..|:..:|..:...:...:|.::|.|:|    :..:::.||.|.
Zfish   679 LSFKLKAVQQSL----EQEEAEHKTTKARLADNNKINQSIEAKSETLKD----MEHKLLEERSAK 735

  Fly   877 RTANLSLWKVEK--------------QLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKT 927
            :.....|.::||              :|:|..|.|:.|..::|:...|:::........|..||.
Zfish   736 QQLENRLMQLEKENSVLDCDYKQAKHELQELRSLKENLTEQVEVLNVRVQQETQRKTLCQGDLKV 800

  Fly   928 SQEETRQRESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELR 992
            .::|.....|..::|||||    ..:|:.....||..||..|               |::|:|
Zfish   801 QRQEINSLRSSEQQLKQEL----NHLLELKLTLEKQNQELSK---------------EREESE-- 844

  Fly   993 QKLRQIQSRFDGVTLEQ------KNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYAC 1051
               :|::...|.:..||      |..||||:||.::..|       |.|:.:|..::.|..:
Zfish   845 ---KQLKEMKDQLEAEQYFTKLYKTQIRELKEESDEKVK-------LYKDAQQRIEDLQEER--- 896

  Fly  1052 SITDSQLTEVE---TMLKSEQ-------------ERNKSQKSQLDTLHEKLRERNDQLTDLRKQL 1100
               ||..:::|   |...|||             |:.|..| :|:......|.|.| |.:....:
Zfish   897 ---DSLASQLEVSLTKADSEQLARITVEEQYSDLEKEKIMK-ELEIKDMIARHRQD-LAEKDGTI 956

  Fly  1101 TTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKL--------------VAQQDQL-VEQTNALF 1150
            .::|...|........||||.:||...||..|:||              |:.:.|: ||:|..:.
Zfish   957 NSLEESNRTLTVDVANLASEKEELNNKLKHIQQKLEKIKEEEKQMKSLTVSYEKQIQVEKTLKIQ 1021

  Fly  1151 ATQERAELL---DGQNANYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAEIRGLESAQ 1212
            |..:.||::   ||:  .::....|..|                  |::|:..||.::| .|..:
Zfish  1022 AINKLAEVMKKTDGR--PHQINNTDIRR------------------KEKEIRQLQLQLR-TEKEK 1065

  Fly  1213 ANLHA------EIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKTLAD 1271
            .| |:      ||:.:|..:||:.|..::..:    :|......|:.|:.::..||.....|.:.
Zfish  1066 LN-HSIIKYQREINDMQAMIAEESQVRLEMQM----SLDSKDSDIERLRSQLTSLSIHSLDTTSI 1125

  Fly  1272 KLFGSSHTNKENVSPNDVESSILYRALKEELKREQKMNSLLKEQLAQLNGTATLRSPRKSAAVNG 1336
            ...|           ||::|...|..........:.|             :.|.:...||..::
Zfish  1126 SSIG-----------NDLDSDEAYPVRITHSHTSESM-------------SFTYQRSSKSVCID- 1165

  Fly  1337 DSDAPKQRPVSIAALPR-----SPQKQQQPLKRTTSQVELKTTAEKPTKVTIENQAHHRFELALQ 1396
                  .||..||  ||     ..::.::...|.|..:..:|..: |.....|:.......:..:
Zfish  1166 ------TRPCRIA--PRFSSDSDEEEDEEDEWRQTPALTYETPPD-PEAAAAESGLEGWLSMPAK 1221

  Fly  1397 ESK---VDAVNCVVCEKAVVAGSPFWKCKECKDVTHRKCRSNVQSHCGSTKPTAP----SADDLS 1454
            .:|   .|....||..|.::    |:..::.::                  .::|    ..|.|.
Zfish  1222 NTKRFGWDKKYVVVSSKKIL----FYDSEQDRE------------------QSSPFMILDIDKLF 1264

  Fly  1455 SIQSVSSLTLDSVDVAGGTTSGGEYIGSLVYSSDGAEDQARKEIEVNCAFEVAEQQILL--LGCN 1517
            .::.|:     ..||..........|..::|:::|  :..::|:.|. :..|.|:.:.:  .|..
Zfish  1265 HVRPVT-----QTDVYRADPREIPRIFQILYANEG--ESKKEELPVE-SLSVTERSLCIPHKGHE 1321

  Fly  1518 TGLYAYHLDSQRLVHISGLESVSCMSICKRLAKAIMVGTVGEKLY---------QCDYRQLESRC 1573
            ..|..||..|            || .:|.|            .|:         :|      .||
Zfish  1322 FVLTLYHFPS------------SC-EVCPR------------PLWHVFRPPPALEC------RRC 1355

  Fly  1574 QSSSSCHKPVLE----------------TSAIELPFANRTPSE-KWKLVL---------ISDEAE 1612
            :  ..|||..::                |:...|..||.|..: ||...|         |:..:.
Zfish  1356 R--VKCHKDHIDRKEEVLAPCRVNYDMSTAKEMLLLANSTEEQKKWVSRLLKRVPRKPSIAHSSS 1418

  Fly  1613 NALDSVAIAATSTRIVILKYDLKLHMFKPVRALDTATPVTSIFFTRHSAIV----------SSDK 1667
            .|:.:....||.|.:          ..:|...|..::|..|     |.|.|          |.::
Zfish  1419 IAISAAPSEATPTTL----------SPQPSPRLAQSSPRLS-----HRAAVKVHSTRQQPSSKNR 1468

  Fly  1668 FYEIDLDNYAAEEFVDLSD 1686
            ..|:.|.::.....|:|.|
Zfish  1469 LLEMGLKDWGWALEVELDD 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	141/350 (40%)
		S_TKc	113..383	CDD:214567	116/277 (42%)
		Smc	487..1222	CDD:224117	180/816 (22%)
		CNH	1503..1774	CDD:279162	44/231 (19%)
rock2b	XP_021324031.1	STKc_ROCK	51..402	CDD:270747	146/374 (39%)
		SMC_N	<432..1097	CDD:330553	181/819 (22%)
		PH_ROCK	1212..1316	CDD:269948	19/133 (14%)
		C1	1320..1374	CDD:237996	15/86 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920