DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and Dmpk

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_038967160.1	Gene:	Dmpk / 308405	RGDID:	1309825	Length:	646	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	181/561 - (32%)
Similarity:	290/561 - (51%)	Gaps:	65/561 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVH 128
            |.|||....::.|.....| .:|:.:|:|:....||....:::|:..|||.|..:||:|.|..|.
  Rat    23 EPLLDLLLGVHQELGASHL-AQDKYVADFLQWVEPIAARLKEVRLQRDDFEILKVIGRGAFSEVA 86

  Fly   129 LVVERQTNDIYAMKKIKK-SVVTTSQV---KEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYM 189
            :|..:||..:||||.:.| .::...:|   :||||::...:..|:..|.:||||.:.|||||||.
  Rat    87 VVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVKGDRRWITQLHFAFQDENYLYLVMEYY 151

  Fly   190 PGGDLLSLMSRHGP-FDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGN 253
            .|||||:|:|:.|. ...::|||||||:.:|:.::|.:|||||||||:|||:||.|||:|||||:
  Rat   152 VGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGS 216

  Fly   254 AAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETT 318
            ...|..||.|.||..||||||::||:||.:.....:.|...     .||:|::|:..||:....|
  Rat   217 CLKLQPDGTVRSLVAVGTPDYLSPEILQAVGGGPGAGSYGP-----ECDWWALGVFAYEMFYGQT 276

  Fly   319 PFHEDNVHETYSKILSHCEESHLKELISFP-ADLKVSVNYRNLIESLVTNPSKRL---SYERIKN 379
            ||:.|:..|||:||:      |.:|.:|.| ||:.|....::||..|:.....||   .....:.
  Rat   277 PFYADSTAETYAKIV------HYREHLSLPRADMGVPEEAQDLIRGLLCPAEIRLGRGGAGDFQK 335

  Fly   380 HPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLT----------TNM 434
            ||||..:.|..:|..|||..|......||.||:            |.:..||          ::|
  Rat   336 HPFFFGLDWEGLRDSVPPFTPDFEGATDTCNFD------------VVEDRLTAMVSGGGETLSDM 388

  Fly   435 KSNDFSGKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDL----LRA 495
            :.:...|..|||:|||:..|      |:.|.::.:.....|:.|:...:::..|  ||    ...
  Rat   389 QEDMALGVHLPFVGYSYSCM------ASRDNQVTDPTPMELEALQLPVSDLQGL--DLPPPVSPP 445

  Fly   496 QQSLRKTDNKSQVVADAKME----IKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEA 556
            .|:..:.|..:..|..|:.|    :::||:.::|:.:...:...:::.::::.:.......:.|.
  Rat   446 DQAAEEADPAAVPVPPAETETMVTLRELQEALEEEVLTRQSLSRELEAIRTANQNFSSQLQEAEV 510

  Fly   557 TITDLLRLNRQKYEEAKI------ASEQRYEKQLADKKQEL 591
            ...||....||..|..::      |.|.....|...::.|:
  Rat   511 RNRDLEAHVRQLQERMEMLQAPGAAGESLTHSQPGGRRVEM 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	143/359 (40%)
		S_TKc	113..383	CDD:214567	118/278 (42%)
		Smc	487..1222	CDD:224117	21/119 (18%)
		CNH	1503..1774	CDD:279162
Dmpk	XP_038967160.1	PKc_like	69..406	CDD:419665	143/359 (40%)
Dmpk	XP_038967160.1	DMPK_coil	472..532	CDD:117396	9/59 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820