DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and Rpgrip1l

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_017456768.1	Gene:	Rpgrip1l / 307724	RGDID:	1311099	Length:	1268	Species:	Rattus norvegicus

Alignment Length:	1044	Identity:	207/1044 - (19%)
Similarity:	392/1044 - (37%)	Gaps:	284/1044 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   842 QEGETVGDMLERQ------NEKLEDKLAAVREQMIVERQAARTANLSLWKVEKQLEEALSEKKLL 900
            ||..|...:..||      .|:|||:...:.::.|:.:|.||.....:.::..:|...:::||
  Rat    28 QETSTARTVKARQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKK-- 90

  Fly   901 ARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEELKQELAAAKRDV-LKEHRQWE--- 961
              |.|......|:: ....|.:.|::..||:..:.|.:.|.||..|.:||:.: ::.|||..
  Rat    91 --RYERVGGGPKRL-GRDVEMEEMIEQLQEKVHELERQNEVLKNRLISAKQQLQVQGHRQTSYSR 152

  Fly   962 ---KAEQERMKCKS-----EIIEHLANVHRLEQQETELRQKLRQIQSRFDGVTLEQKNTIRELQE 1018
               :....|.|..:     |.:.....|..:::.|| ::..|.:..|   |:..|.:..||.|:.
  Rat   153 VQARTNTGRRKASTTAGLQECLGKGIKVQNVDEAET-VQPTLTKYSS---GLLEEARGEIRNLEN 213

  Fly  1019 EREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQL----TEVE-TMLKSEQERNKSQKS- 1077
                         |:|.:..|:    :.|::...|..:||    .|:| ::|:..:::...|:|
  Rat   214 -------------VIQSQRGQI----EELEHLAEILKTQLKRKENEIELSLLQLREQQATDQRSN 261

  Fly  1078 -----QLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKLVA 1137
                 ::..||::|.|:::.|:.:..:...::.::|........|.:..|||.:.||||:.|..:
  Rat   262 IRDNVEMIKLHKQLVEKSNALSVIEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCS 326

  Fly  1138 QQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSLKEENARILSELF---HK----- 1194
            .:.||   .:..|:.:...||.|..|        |..:|...|||...::.:..|   |:
  Rat   327 LEKQL---HSVRFSERRVEELQDRIN--------DLEKERELLKENYDKLYNSAFSAAHEEQWKL 380

  Fly  1195 KEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDY---LQL 1256
            ||:  .::.:|..||:|          |:..|.:|.:...|...:....:.|::||:..   |||
  Rat   381 KEQ--QMKVQIAQLETA----------LKSDLTDKAEVLDQLKTERGPLINQNEKLVQENRDLQL 433

  Fly  1257 KVEDLSAKKKKTLADKLFGSSHTNKE-NVSPNDVESSILYRALKEELKREQKMNSLLKEQLAQLN 1320
            :    ..::|:.|.:........|:| :::.:|:..::|                |:|.|..|.|
  Rat   434 Q----CLQQKQQLHELQNRMKFFNQESDINVDDLSEALL----------------LIKAQKEQKN 478

  Fly  1321 GTATLRSPRKSAAVNGDSDAPKQRPVSIAALPRSPQKQQQPLKRTTS------------QVELKT 1373
            |..:... :..:.:|.|.|.      |:..|..:..:..|.|::|.:            |:|::|
  Rat   479 GDLSFLE-KVDSKINKDLDR------SMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVET 536

  Fly  1374 TAEK------PTKVTIENQAHHRFELALQESKVDAVNCVVCEKAVVAGSPFWKCKECKDVTHRKC 1432
            ..:|      ..::.:|...|.....|.:..|::|                    :.||:.:
  Rat   537 VTQKMENLQQDHELKVEQYVHLLDVRAARIQKLEA--------------------QLKDIAY--- 578

  Fly  1433 RSNVQSHCGST----KPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIGSLVYSSDGAEDQ 1493
                    |:.    ||.....|.:....       :::.:..|......:|..:.::||.....
  Rat   579 --------GTKQYKFKPEIMPDDSVDEFD-------ETIHLERGENLFEIHINKVAFASDVLRAS 628

  Fly  1494 ARKEIEVNCA-----FEVAEQQILLLGCNTGLYAYHLDSQRLVHISGLESVSCMSICKRLAKAIM 1553
            ..||:...|.     ||:....|:...|.    .|:..||.|||::.|           ..:.|.
  Rat   629 GDKELLTFCTYAFYDFELQTTPIVRGPCP----EYNFTSQYLVHVNDL-----------FLQYIQ 678

  Fly  1554 VGTVGEKLYQC---DYRQLESRCQSSSSCHKPVLETS--------------------AIELPFAN 1595
            ..||..:|:|.   ||..: :.||  ...|: :||.|                    .:|..|..
  Rat   679 KNTVTLELHQAYSTDYETV-AACQ--LRFHE-ILEKSGRIFCTTSLVGTKGDIPNFGTVEYWFRL 739

  Fly  1596 RTPSEK----------------------WKLVLISDEAENALDSVAIAATSTRIVILKYDLK--L 1636
            |.|.::                      .|:.|:|.:|.......:..:|...:..|...::  .
  Rat   740 RVPMDQAIRLYRERAKALGYITSNFKKPEKMQLLSQQAATTAQISSPESTDGNLNELHITVRCCT 804

  Fly  1637 HMFKPVRALDTATPVTSIFF---TRHSAIV--SSDKFYE----------IDLDNYAAEE---FVD 1683
            ::....|.|.....|...||   ...:||:  |:|..::          :|||.|...|   |..
  Rat   805 NLQSRARHLQPHAYVVYKFFDFPDHDTAIIPSSNDPQFDDYMCFPVPMNMDLDRYLKSESLSFYV 869

  Fly  1684 LSDKSMEST---AKCQ-PLTAVRISRQEYLLCFAEYGVF----VDEFGCRSRPYDLNWVYA---P 1737
            ..|..::..   .|.. ||.::...|     |.:  |:|    .|:....:....|.|.:.   |
  Rat   870 FDDSDIQENIYIGKVNVPLISLAHDR-----CIS--GIFELMDKDKHAAGTIQVILKWKFTYLPP 927

  Fly  1738 TGFV 1741
            :|.:
  Rat   928 SGSI 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	93/416 (22%)
		CNH	1503..1774	CDD:279162	62/320 (19%)
Rpgrip1l	XP_017456768.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000