DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and Cdc42bpg

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_038964401.1	Gene:	Cdc42bpg / 293693	RGDID:	1307260	Length:	1558	Species:	Rattus norvegicus

Alignment Length:	1914	Identity:	435/1914 - (22%)
Similarity:	694/1914 - (36%)	Gaps:	682/1914 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVH 128
            :||||....::.|.....| :|:||:|:|::...|.:.:.::||:..|||.|..:||:|.||.|.
  Rat    23 DGLLDLLLGVHQELSSAPL-RRERNVAQFLSWAGPFVTKVKELRLQRDDFEILKVIGRGAFGEVA 86

  Fly   129 LVVERQTNDIYAMKKIKK----SVVTTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYM 189
            :|.:|.:..|:|||.:.|    ....|:..:||||::...:|.|:..|.|||||.:.|||||:|.
  Rat    87 VVRQRDSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYY 151

  Fly   190 PGGDLLSLMSRHGPFDE----DLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLAD 250
            .|||||:|:||   |::    :||:|||||:.:|:|:||::||||||:||:|||:|..|||:|||
  Rat   152 AGGDLLTLLSR---FEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLAD 213

  Fly   251 FGNAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELIC 315
            ||:...|:.:|.|.|...|||||||:||:||.:...|....       ..||:||:|:..|||:.
  Rat   214 FGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYG-------PQCDWWSLGVCAYELLF 271

  Fly   316 ETTPFHEDNVHETYSKILSHCEESHLKELISFPADL-KVSVNYRNLIESLVTNPSKRL---SYER 376
            ..|||:.:::.|||.||::|  |.||:    ||:|: .|..:.:.||..|:....:||   ..:.
  Rat   272 GETPFYAESLVETYGKIMNH--EDHLQ----FPSDVDDVPASAQALIRQLLCRQEERLGRGGLDD 330

  Fly   377 IKNHPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSND-FS 440
            .::||||..:.|..:.:...|.||.:|...|||||:        .:.....:..|....|:. ||
  Rat   331 FRSHPFFEGVDWERLATSTAPYIPELRGPVDTSNFD--------VDDDTLNRPETLPPSSHGAFS 387

  Fly   441 GKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKTDNK 505
            |..|||:|:::          |:.....:|..||:...:.:.:.:..:|.:|          ..|
  Rat   388 GHHLPFVGFTY----------TSGSLTDDKSSELMATPEWKPHGVEQMKVEL----------SQK 432

  Fly   506 SQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQKYE 570
            .||..           ::.|             .|.||.:..|            |:||.:
  Rat   433 CQVAL-----------LLPE-------------ALHSSLQPQE------------LVRLQK---- 457

  Fly   571 EAKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQQIKEQNLK 635
            |.::..|:..| .|.|.|    ::|.:.|...:...|.       .::||..||.|||
  Rat   458 EVQVLQEKLTE-TLRDSK----ASLSQADGLHVRSPAP-------DIQLQQEKDRLQQ------- 503

  Fly   636 SETNHEEQRRQMAELYEQKLTDLRKKVRDS---QDTNRRMTMEIKEIRTELDESISSSKSTQEAK 697
                      ::||      .....:|||:   |..||:
  Rat   504 ----------ELAE------AQAALQVRDAELCQAQNRQ-------------------------- 526

  Fly   698 NATERNIEEILRRLNE----EIASNNELHAEKVKLETKLQLKENETQEVRAECHRLERELQLAEC 758
                   ||.|:||.|    |.|:.:::.|...:||....::    :|:..:.:.|.:|:...:.
  Rat   527 -------EEFLQRLWEAQEREAAAASQIQALNSQLEEAWVVR----RELEGQVNTLSQEVTQLQG 580

  Fly   759 RCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQML 823
            :|:...||.|..|   ..||    |.|.|.
  Rat   581 QCKQDSSSQAKTV---HAAP----ETNGIG----------------------------------- 603

  Fly   824 ERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAARTANLSLWKVEK 888
                    ||         ||::       |..:|..::||:|||:    :.|.:..:::.|.|
  Rat   604 --------SP---------EGQS-------QEAQLRKEVAALREQL----ECACSQGVNVGKEE- 639

  Fly   889 QLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEELKQELAAAKRDV 953
                      :|.|..|              |.||:       :|::|...|||..||.:.:|
  Rat   640 ----------VLCRLQE--------------ENQRL-------SREQERLAEELDLELQSRQR-- 671

  Fly   954 LKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQSRFDGVTLEQKNTIRELQE 1018
                     .|.||.:.:|.....:|::......|...|..|:.:.::              :.|
  Rat   672 ---------LEGERRESESNWEAQIADILSWVNDEKVSRGYLQALATK--------------MAE 713

  Fly  1019 EREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETMLKSEQERNKSQKSQLDTLH 1083
            |.|..|......|..:.     .|:..:.:....:..|...|:::.|::|
  Rat   714 ELESLRNVGTQTLPTRP-----LDHQWKARRLQKMEASARLELQSALEAE--------------- 758

  Fly  1084 EKLRERNDQLTDLRKQLTTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKLVAQQDQLVEQTNA 1148
              :|.:.    .|::|||.|:..:|.||:|              |:|.:|     |:|.::|
  Rat   759 --IRAKQ----GLQEQLTQVQEAQRQAERR--------------LQEAEK-----QNQALQQ--- 795

  Fly  1149 LFATQERAELLDGQNANYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAEIRGLESAQA 1213
                                       |:..|:||                 |||  ||...|
  Rat   796 ---------------------------EVAELREE-----------------LQA--RGPGDA-- 812

  Fly  1214 NLHAEIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKTLADKLFGSSH 1278
                                                               |..|....|....:
  Rat   813 ---------------------------------------------------KPCTSLIPLLSFWN 826

  Fly  1279 TNKENVSP--NDVES--SILYRALKEELKREQKMNSLLKEQLAQLNGTATLRSPRKSAAVNGDSD 1339
            |.|::...  |..||  |.....|:.|.:|..:|.|:.               ||..||....::
  Rat   827 TEKDSAKDPGNSGESPRSGAEAELRPEGRRSLRMGSVF---------------PRVPAANPTPAE 876

  Fly  1340 APKQRPVSIAALPRSPQKQQQPLKRTTSQVELKTTAEKPTKVTIENQAHHRFELALQESKVDAVN 1404
            .|..:|.|....|||                    ...|||
  Rat   877 GPPAKPGSHTLRPRS--------------------FPSPTK------------------------ 897

  Fly  1405 CVVCEKAVVA-GSPFWKCKECKDVTHRKCRSNVQSHCGSTKPTAPSADDL--------------- 1453
            |:.|...::. |.....|..|....|        |.|.:..|..|...:|
  Rat   898 CLHCTSLMLGLGRQGLGCDTCGYFCH--------SACATQAPPCPVPPELLRTALGVHPETGTGT 954

  Fly  1454 ----------------------SSIQSVSSLTLDSVDVAGGTTSG----------GEYIGSLVYS 1486
                                  :::.....|..|:.|..|...||          .::..:.|.:
  Rat   955 AYEGFLSVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRGSMASGVLLQALDLRDPQFSATPVLA 1019

  Fly  1487 SDGAEDQARKEIEVNCAFEVAEQQ---------ILLLGCNTG-----------LYAYHLDSQ--- 1528
            .|....|::   ::...|.|...|         :|||..|.|           |....||::
  Rat  1020 PDVIHAQSK---DLPRIFRVTASQLTVPPSTCTVLLLAENEGERERWLQVLSELQRLLLDARPRP 1081

  Fly  1529 ------RLVHISGLESVS---CMSIC--KRLAKAIMVGTVGEKLYQCDYRQLESRCQSSSSCHK- 1581
                  :..:.:||..:.   |.:|.  :|||.....|.....|:..|..|:       ..|.:
  Rat  1082 RPVYTLKEAYDNGLPLLPHTLCAAIIDRERLALGTEEGLFVIHLHSNDIFQV-------GDCRRV 1139

  Fly  1582 ---PVLETSAIELPFANRTPSEKWKLVLISDEAENA-----------------LDSVAIAATSTR 1626
               .|...:.:.:....|.||.  :|..:| |.|||                 ..|:..|.|...
  Rat  1140 QRLTVSSAAGLLVVLCGRGPSV--RLFTLS-ELENAEVAGAKIPESRGCQALVAGSILQARTPVL 1201

  Fly  1627 IVILKYDLKLHMFKP--------VRALDTATPVTSI-FFTRHSAIVSSDKFYEIDLDNYAAEEFV 1682
            .|.:|..:..:...|        :|.|....||.|: .......:.::..|....|.|.||...:
  Rat  1202 CVAVKRQVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGTFALYPLLNEAAPLAL 1266

  Fly  1683 DLSDKSMESTAK----CQPLTAVRISRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTGFVYR 1743
            .....:.|..|.    .:.|.||.:|..|.||.||..||:||..|.:||.::|.|..||||:.|.
  Rat  1267 GTGLVAEELPASRGGLGEALGAVELSLSELLLLFATAGVYVDGAGRKSRSHELLWPVAPTGWGYT 1331

  Fly  1744 DPFLFISHYQSVQIVRLHRSFSKEMASGDNASENSESPELQRVYLPHYMSTLLANSGDVNLYAVA 1808
            .|:|.:....|:.:..:.|            :|..::..|::|       ..|...|.:.||
  Rat  1332 APYLTVFSENSIDVFDVRR------------AEWVQTVPLKKV-------RPLNPEGSLLLY--- 1374

  Fly  1809 IDQRPCNGTQKI--YHLDTMQAFKQKFNI 1835
                   ||:|:  .:|....|.|.:|:|
  Rat  1375 -------GTEKVRLTYLRNPLAEKDEFDI 1396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	144/353 (41%)
		S_TKc	113..383	CDD:214567	121/281 (43%)
		Smc	487..1222	CDD:224117	133/741 (18%)
		CNH	1503..1774	CDD:279162	78/338 (23%)
Cdc42bpg	XP_038964401.1	STKc_DMPK_like	69..399	CDD:270748	144/363 (40%)
		SMC_prok_B	<450..809	CDD:274008	122/667 (18%)
		C1_MRCKgamma	885..936	CDD:410416	16/102 (16%)
		PH_MRCK	944..1076	CDD:269949	18/134 (13%)
		CNH	1103..1366	CDD:395630	68/291 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920