DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and NBPF14

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_001382560.1	Gene:	NBPF14 / 25832	HGNCID:	25232	Length:	2988	Species:	Homo sapiens

Alignment Length:	1433	Identity:	266/1433 - (18%)
Similarity:	495/1433 - (34%)	Gaps:	422/1433 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 WSKKEATITDLLRLNRQKYEEAKIASEQRYEKQLADKKQELASTLQKLDAREL-------EFNAK 608
            ||.::|.: ::|.:|            :....|||:|||:..:..:|....:|       :...|
Human     8 WSSEKAEM-NILEIN------------ETLRPQLAEKKQQFRNLKEKCFLTQLAGFLANQQKKYK 59

  Fly   609 FEECKHL-SMKLQNYKDMLQQIKEQNLKSETNHEEQRRQ---MAELYEQKLTDLRKKVRDSQDTN 669
            :||||.| ...|:|.:    |.||:.|..:....|:.||   :....|::||.||:|:|:.:|.:
Human    60 YEECKDLIKFMLRNER----QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

  Fly   670 RRMTMEIKEIRTELDESISSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQL 734
            |.:...::.:.|..:...|..:..||......|..:.::::|:.|   |:|...|.|::|...::
Human   121 RSLYEHLQALLTPYEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPE---NDEDEDEDVQVEEAEKV 182

  Fly   735 KENETQEVRAECHRLERELQLAECRCQLAESSL-------ATQVSPYET-APGSLTELNAIEDQL 791
            .|:..          .||:|.|| ..::.|.||       :....|.:: .|....::...||::
Human   183 LESSA----------PREVQKAE-ESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEV 236

  Fly   792 RADLLAAKESENHQKGRADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNE 856
            .:.|:..:||.:      |:.|..:..|...         .||.|
Human   237 NSTLVVDRESSH------DECQDALNILPVP---------GPTSS-------------------- 266

  Fly   857 KLEDKLAAVREQMIVER--QAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASD 919
                   |....|:|..  .::..|.:::.::.::|...|:|||             ::.:|..:
Human   267 -------ATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKK-------------QQFRNLKE 311

  Fly   920 EAQRMLKTSQEETRQRESRIEELKQELAAAKRDVLKEHRQW-EKAEQERMKCKSEIIEHLANVHR 983
            :......:.....:|::.:.||.|..:    :.:|:..||: |:...|::|...|:.::...||.
Human   312 KCFLTQLSGFLANQQKKYKYEECKDLI----KFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHA 372

  Fly   984 LEQQETELRQKLRQIQSRFDGVTLEQKNTIRELQEEREKSRKANDSCLVL----QKELKQLTDNF 1044
            .|::.|:||:|||                     |.|:.||..|:....|    :.:..|..|..
Human   373 QERELTQLREKLR---------------------EGRDASRSLNEHLQALLTPDEPDKSQGQDLQ 416

  Fly  1045 QRLKYACSITDSQLTEVETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRL 1109
            ::|...|.:....:.:    |..|.:.:..:..|:: :.||:            |.::...|.:.
Human   417 EQLAEGCRLAQHLVQK----LSPENDNDDDEDVQVE-VAEKV------------QKSSAPREMQK 464

  Fly  1110 AEQRAQVLASEIDELRL-----------NLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQN 1163
            ||:: :|....::|..:           |...::.|:..::|: |:.|  |..:....|..|..:
Human   465 AEEK-EVPEDSLEECAITYSNSHGSYDSNQPHRKTKITFEEDK-VDST--LIGSSSHVEWEDAVH 525

  Fly  1164 ANYEAQTADSNREMV------SLKE-ENARILSELFHKKEEVGNLQAE-IRGLESAQANLHAEID 1220
            ...|.::.|...|..      :|:| |...:..|.:.:.....::..| :...:|..:..|:
Human   526 IIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHS--- 587

  Fly  1221 SLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQLKVED------------LSAKKKKTLADKL 1273
                  .|::|..:..||      .:|:    :.|:|.||            |..|..:.|.|.|
Human   588 ------LEEQQVCMAVDI------GRHR----WDQVKKEDQEATGPRLSRELLDEKGPEVLQDSL 636

  Fly  1274 -------------------FGSSHTNKEN------VSPNDVESSILYRALKEE-------LKRE- 1305
                               :.|:....|.      |..:::|.   |:.::|:       |.||
Human   637 DRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK---YQEVEEDQDPSCPRLSREL 698

  Fly  1306 --QKMNSLLKEQLAQLNGTAT-------LRSPRKSAA----------------VNGDSDAPKQRP 1345
              :|...:|::.|.:...|.:       |..|..||.                :..|.:..:.:.
Human   699 LDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQD 763

  Fly  1346 VSIAALPR------SPQKQQQPLKRTTSQVELKTTAEKPTKVTIENQAHHRFELALQESKVD-AV 1403
            .....|.|      .|:..|..|.|..|..  .:..|:|...    |.:.....||:|..|. ::
Human   764 PPCPRLSRELLEVVEPEVLQDSLDRCYSTP--SSCLEQPDSC----QPYGSSFYALEEKHVGFSL 822

  Fly  1404 NCVVCEKAVVAGSPFWKCKECKDVTHRKCRSNVQSHCG------STKPTAPSADDLSSIQSVSSL 1462
            :....|            |:.|....|..||..:...|      ...|..|........:....:
Human   823 DVGEIE------------KKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEV 875

  Fly  1463 TLDSVDVAGGTTSG-------GEYIGSLVYSSDGAEDQARKEIEVNCAFEVAEQQILLLGCNTGL 1520
            ..||:|....|.||       |:...|.|||                    .|:|.|.|.
Human   876 LQDSLDRCYSTPSGYLELPDLGQPYSSAVYS--------------------LEEQYLGLA----- 915

  Fly  1521 YAYHLDSQRLVHISGLE---SVSCMSICKRLAKAIMVGTVGEKLYQCDYRQLESRCQSSSSC--- 1579
                ||..|:......|   ...|..:.:.|.:.:....:.:.|.:| |....|..:...||
Human   916 ----LDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRC-YSTPSSCLEQPDSCQPY 975

  Fly  1580 --------HKPV---LETSAIELPFANR-----------------------TPSEKWKLVLISDE 1610
                    .|.|   |:...||.....:                       .|..:....|:.::
Human   976 GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEK 1040

  Fly  1611 AENALDSVAIAATSTRIVILKYDLKLHMFKPVRALDTATPVTSIFFTRHSAIVSSDKFYEIDLDN 1675
            ....|........||....|:            ..|:..|..|.|:......|.    ..:|:|.
Human  1041 GPEVLQDSLDRCYSTPSGCLE------------LTDSCQPYRSAFYVLEQQRVG----LAVDMDE 1089

  Fly  1676 YAAEEFVDLSDKSMESTAKCQPLTAVRISRQEYLLCFAEYGVFVDEFG-CRSRPY------DLNW 1733
              .|::.::.:.        |..:..|:||:  ||...|..|..|... |.|.|.      ||..
Human  1090 --IEKYQEVEED--------QDPSCPRLSRE--LLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQ 1142

  Fly  1734 VYAPTGFVYRDPFLFISHYQSVQIVRLHRSFSKEMASGDNASENSESPELQRVYLPHYMSTLLAN 1798
            .|:...:...:.:|.:    ::.:.|:.:...:|      ..::...|.|.|..|......:|.:
Human  1143 PYSSAVYSLEEQYLGL----ALDVDRIKKDEEEE------EDQDPPCPRLSRELLEVVEPEVLQD 1197

  Fly  1799 SGD 1801
            |.|
Human  1198 SLD 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	140/715 (20%)
		CNH	1503..1774	CDD:279162	53/317 (17%)
NBPF14	NP_001382560.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000