DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and Rock2

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_008762796.1	Gene:	Rock2 / 25537	RGDID:	3590	Length:	1473	Species:	Rattus norvegicus

Alignment Length:	1620	Identity:	410/1620 - (25%)
Similarity:	677/1620 - (41%)	Gaps:	401/1620 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SASGSGIPASTRRSIVPVSTTSAAVAEAICR--------EGLLDAFCLLYNECDKDTLKKRDRNI 89
            :|.|.|..|..:|.:           ||:.|        |.|||....|..:.|...|:| ::||
  Rat    16 AAPGDGAGAGRQRKL-----------EALIRDPRSPINVESLLDGLNSLVLDLDFPALRK-NKNI 68

  Fly    90 AEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLVVERQTNDIYAMKKIKK-SVVTTSQ 153
            ..|:|::..|:::.|.|::.|:|:.:..:||:|.||.|.||..:.:..:||||.:.| .::..|.
  Rat    69 DNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSD 133

  Fly   154 VK---EERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAE 215
            ..   ||||||:..||.|::.|..||||:..||:||||||||||::|||.: ...|..|:||.||
  Rat   134 SAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAE 197

  Fly   216 LTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAALDRDGHVLSLSPVGTPDYIAPELL 280
            :.:||..:|.||.:|||:||:|:|:|:.||:||||||....:|..|.|...:.|||||||:||:|
  Rat   198 VVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 262

  Fly   281 QTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELI 345
            ::        ...|......||:||:|:..:|::...|||:.|::..|||||:.|      |..:
  Rat   263 KS--------QGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDH------KNSL 313

  Fly   346 SFPADLKVSVNYRNLIESLVTNPSKRL---SYERIKNHPFF--SEIPWGSIRSQVPPIIPTVRSD 405
            .||.|.::|.:.:|||.:.:|:...||   ..|.||.||||  .:..|.:||....|::|.:.||
  Rat   314 CFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSD 378

  Fly   406 DDTSNFEDGIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPFIGYSFVH-----------MEKSAI 459
            .|:|||:|....|...|.....|:         |.|..|||||:::..           .|..||
  Rat   379 IDSSNFDDIEDDKGDVETFPIPKA---------FVGNQLPFIGFTYFRENLLLSDSPPCRENDAI 434

  Fly   460 SATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKTDNKSQVVADAKMEIKKLQQIIK 524
            .....|:.|    |:.:||...|..:|                   |:|.|..::|.|
  Rat   435 QTRKSEESQ----EIQKKLYALEEHLS-------------------SEVQAKEELEQK------- 469

  Fly   525 EKTMELTTCKTQIKTLQSSAK-IDEEMWSKKEATITDLLRLNRQK-YEEAKIASEQRYEKQLADK 587
                    ||:....|:.:|| ::||:..:|....| |.:|.|:| ..:.|.|..||.....|||
  Rat   470 --------CKSINTRLEKTAKELEEEITFRKNVEST-LRQLEREKALLQHKNAEYQRKADHEADK 525

  Fly   588 KQELASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQQIKEQNLKSETNHEEQRRQMAELYE 652
            |:.|.:.:..|                        ||.|:.:|::|..|:.:
  Rat   526 KRNLENDVNSL------------------------KDQLEDLKKRNQSSQIS------------- 553

  Fly   653 QKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQEAKNATERNIEEILRRLNEEIAS 717
                                |.::.:::.:|||:           ||..|...:...||
  Rat   554 --------------------TEKVNQLQKQLDEA-----------NALLRTESDTAARL------ 581

  Fly   718 NNELHAEKVKLETKLQLKENETQEVRAECHRLERELQLAECRCQLAESSLATQVSPYETAPGSLT 782
                  .|.:.|:..|:::.|:.         .|:||...|..:.|:..|..:.         :.
  Rat   582 ------RKTQAESSKQIQQLESN---------NRDLQDKNCLLETAKLKLEKEF---------IN 622

  Fly   783 ELNAIEDQLRADLLAAKESENHQKGRADQLQ-------TLVTKLEQMLERFNEQSLSPTKSHSSR 840
            ..:|:|.: |.|.....|..|..:||...|:       ||:.|:|  ||               :
  Rat   623 LQSALESE-RRDRTHGSEIINDLQGRISGLEEDLKTGKTLLAKVE--LE---------------K 669

  Fly   841 KQEGETVGDMLERQNEKLEDKLA---AVREQMIVERQA------ARTANLSLWKVEKQLEEALS- 895
            :|..|.:.| ||::...:|..:.   .|.:|.:.:.:|      ||.|:.:  |:.:.:|||.|
  Rat   670 RQLQEKLTD-LEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADKN--KIYESIEEAKSE 731

  Fly   896 -----EKKLLARRMELTEDRIKKVQNASDEAQRM-------LKTSQ--------------EETRQ 934
                 |||||..|     ...:||:|...||::.       ||.||              |:.|.
  Rat   732 AMKEMEKKLLEER-----SLKQKVENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDVRN 791

  Fly   935 RESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVH-RLEQQETELRQKLR-- 996
            ...:||:..|:....:.|:..:.:|....:....:.|.| ..||..:. .||:|..|||::.:
  Rat   792 LTLKIEQETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQE-NNHLMEMKMNLEKQNAELRKERQDA 855

  Fly   997 --QIQSRFDGVTLEQ------KNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSI 1053
              |::...|.:..||      |..:|||:||.|:..|.   |..||::.:.|.|....|.....|
  Rat   856 DGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKL---CKELQQKKQDLQDERDSLAAQLEI 917

  Fly  1054 T----DSQLTEVETMLKSEQ----ERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLA 1110
            |    ||:  ::...:..||    |:.|..| :|: :.|.:.....:||:....:.::|...|..
  Rat   918 TLTKADSE--QLARSIAEEQYSDLEKEKIMK-ELE-IKEMMARHKQELTEKDATIASLEETNRTL 978

  Fly  1111 EQRAQVLASEIDELRLNLKEQQKKLVAQQDQ---------------LVEQTNALFATQERAELLD 1160
            ......||:|.:||...||:.|::|...:|:               |.|:|....|..:.||:::
  Rat   979 TSDVANLANEKEELNNKLKDTQEQLSKLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMN 1043

  Fly  1161 -------GQNANYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAEIRGLESAQANLHAE 1218
                   |.:.:...:..::.:..:.||.|..::..::...::|:..:||:|......:..|...
  Rat  1044 RKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMT 1108

  Fly  1219 IDS----LQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQLKV------EDLSAKKKKT----- 1268
            :||    ::...::.:..::..|..|..:.....:..|...:.:      |.:|...:::
  Rat  1109 LDSKDSDIEQLRSQLQALHIGMDSSSIGSGPGDAEPDDGFPVHITQSHTMESMSFTYQRSSTSLN 1173

  Fly  1269 LADKLFGSSHTNKENVSPNDVESSILY-RALKEELKREQKMNSLLKEQLAQLNGTATLRSPRKSA 1332
            :|.|. .|||...::.|..|   |:.| .:..|.:..|.::...|  .|...|.|......:|..
  Rat  1174 IATKP-SSSHMLLDSDSEED---SLPYLPSSSEPISTESRLEGWL--SLPVRNNTKKFGWVKKYV 1232

  Fly  1333 AVNG------DSDAPKQ----------------RPVSIAALPRSPQKQQQPLKRT--TSQVELKT 1373
            .|:.      ||:..|:                |||:...:.|:..|:...:.:.  .::.|.|.
  Rat  1233 IVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKK 1297

  Fly  1374 TAEKPTKVTIENQAH-----HRFELALQESKVDAVNCVVCEKAVVAGSPFW---------KCKEC 1424
            ..|.|.:...|...:     |.|...|...   ..||..|.|      |.|         :|:.|
  Rat  1298 EPEFPVEPVGEKSNYICHKGHEFIPTLYHF---PTNCEACMK------PLWHMFKPPPALECRRC 1353

  Fly  1425 KDVTHRKCRSNVQSHCGSTKPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIGSLV 1484
                |.||.   :.|....:...........|.|..:|.|    :|..|....:::..||
  Rat  1354 ----HIKCH---KDHMDKKEEIIAPCKVYYDISSAKNLLL----LANSTEEQQKWVSRLV 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	141/349 (40%)
		S_TKc	113..383	CDD:214567	116/276 (42%)
		Smc	487..1222	CDD:224117	177/824 (21%)
		CNH	1503..1774	CDD:279162
Rock2	XP_008762796.1	STKc_ROCK2	39..417	CDD:270771	157/402 (39%)
		S_TKc	92..354	CDD:214567	116/276 (42%)
		Smc	<437..1101	CDD:224117	181/834 (22%)
		HR1_ROCK2	505..571	CDD:212028	23/133 (17%)
		Rho_Binding	979..1046	CDD:286056	16/66 (24%)
		PH_ROCK	1208..1314	CDD:269948	19/107 (18%)
		C1	1318..1364	CDD:237996	15/61 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920