DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and Rpgrip1l

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_006531054.1	Gene:	Rpgrip1l / 244585	MGIID:	1920563	Length:	1268	Species:	Mus musculus

Alignment Length:	853	Identity:	174/853 - (20%)
Similarity:	329/853 - (38%)	Gaps:	242/853 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 IKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKST 693
            :|.:...|..:.||...:...|:::.:. |::..|..:|       :||.:.|:|...::..|..
Mouse    36 VKTRQAVSRVSREELEDRFLRLHDENIL-LKQHARKQED-------KIKRMATKLIRLVNDKKRY 92

  Fly   694 QEAKNATER-----NIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAECHRLEREL 753
            :......:|     .:||::.:|.|::   :||..:...|:.:|   .:..|:::.:.||
Mouse    93 ERVGGGPKRLGRDVEMEEMIEQLQEKV---HELERQNEVLKNRL---ISAKQQLQVQGHR----- 146

  Fly   754 QLAECRCQL--------AESSLATQVSP-----------YETAPGSLTEL-NAIEDQLRADLLAA 798
            |.:..|.|.        |.:|..:|..|           .||...:||:. |::.::.|.::...
Mouse   147 QTSYSRVQARVNTGRRRASASAGSQECPGKGLRFQNVDEAETVQPTLTKYSNSLLEEARGEIRNL 211

  Fly   799 KESENHQKGRADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLA 863
            :.....|:|:.::|:.|...|:..|:|                           ::|| :|..|.
Mouse   212 ENVIQSQRGQIEELEHLAEILKTQLKR---------------------------KENE-IELSLL 248

  Fly   864 AVREQMIVERQAARTANLSLWKVEKQLEE---ALS--EKKLL-----ARRMELTEDRIKKVQNAS 918
            .:|||...::::....|:...|:.|||.|   |||  |.|.:     .|.:.::.|.:  :.| .
Mouse   249 QLREQQATDQRSNIRDNVETIKLHKQLVEKSNALSVIEGKFIQLQEKQRTLRISHDAL--MAN-G 310

  Fly   919 DEAQRMLKTSQ----------EETRQRESRIEELKQEL--AAAKRDVLKEH-------------- 957
            ||..:.||..:          ...|..|.|:|||:..:  ...:|::|||:
Mouse   311 DELNKQLKEQRLKCCSLEKQLHSVRFSERRVEELQDRINDLEKERELLKENYDKLYNSAFSAAHE 375

  Fly   958 RQWEKAEQERMKC---------------KSEIIEHLANV--------HRLEQQETEL-------R 992
            .|| |.::::||.               |:|:::.|...        .:|.|:..:|       :
Mouse   376 EQW-KLKEQQMKVQIAQLETALKSDLTDKTEVLDKLKTERGPLINQNEKLVQENRDLQLQCLQQK 439

  Fly   993 QKLRQIQSRFDGVTLEQKNTIRELQE-----EREKSRKANDSCLVLQKELKQLTDNFQRLKYACS 1052
            |:|.::|||......|......:|.|     :.:|.:| |.....|:|...::..:..|     |
Mouse   440 QRLHELQSRLKFFNQESDINADDLSEALLLIKAQKEQK-NGDLSFLEKVDSKINKDLDR-----S 498

  Fly  1053 ITDSQLTEVETMLKSEQER---------NKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKR 1108
            :.:.|.|..||:.:.|:.|         ||..:.:::|:.:|: |...|..:|:     ||....
Mouse   499 MKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVETVTQKM-ENLQQDYELK-----VEQYVH 557

  Fly  1109 LAEQRA---QVLASEIDELRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNA------ 1164
            |.:.||   |.|.:::.::....|:.:.|.....|..|::.:      |...|..|:|.
Mouse   558 LLDIRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFD------ETIHLERGENLFEIHIN 616

  Fly  1165 ----NYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAE--IRGLESAQANLHAEIDSLQ 1223
                :.|...|..::|:|:       ..:..|:..|    ||..  :||       |:.|.:...
Mouse   617 KVTFSSEVLRASGDKELVT-------FCTYAFYDFE----LQTTPIVRG-------LYPEYNFTS 663

  Fly  1224 DTLAEKEQFYVQRDIKSNATLAQHK------KLIDYLQLKVEDLSAKKKKTLADKLFGSSHTNKE 1282
            ..|......::|...|:..||..|:      :.|...||:..::..|..:....    :|....:
Mouse   664 QYLVHVNDLFLQYIQKNTVTLELHQAHSTDYETIAACQLRFHEILEKSGRIFCT----TSLVGTK 724

  Fly  1283 NVSPN------------DVESSI-LYRA-------LKEELKREQKMNSLLKEQLAQLNGTATLRS 1327
            ...||            .::.:| |||.       :....|:.:|| .|..:|.|    |....|
Mouse   725 GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKKPEKM-QLSSQQAA----TTAQIS 784

  Fly  1328 PRKSAAVN 1335
            |.:|...|
Mouse   785 PAESTDGN 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	146/712 (21%)
		CNH	1503..1774	CDD:279162
Rpgrip1l	XP_006531054.1	SbcC	<47..577	CDD:223496	124/592 (21%)
		C2-C2_1	602..741	CDD:371629	28/160 (18%)
		C2	796..895	CDD:175973
		RPGR1_C	1098..1261	CDD:375560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000