DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and STK38L

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_024304657.1	Gene:	STK38L / 23012	HGNCID:	17848	Length:	521	Species:	Homo sapiens

Alignment Length:	495	Identity:	144/495 - (29%)
Similarity:	220/495 - (44%)	Gaps:	141/495 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AICREGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYF 124
            |:..|||.|       |..|....:..|...||:        ..::.|:..|||....:||:|.|
Human    52 AMEEEGLAD-------EEKKLRRSQHARKETEFL--------RLKRTRLGLDDFESLKVIGRGAF 101

  Fly   125 GNVHLVVERQTNDIYAMKKIKKSVV----TTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLV 185
            |.|.||.::.|..|||||.::||.:    ..:.::.||||:...:..|::.:.|:|||..||||:
Human   102 GEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLI 166

  Fly   186 MEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLAD 250
            ||::||||:::|:.:.....|:..:||::|..:|:..:|::|::||||||:|:|:|..||:||:|
Human   167 MEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSD 231

  Fly   251 FGNAAALD-----------------------------------RDGHVLSLSP------------ 268
            ||....|.                                   |:..||||||
Human   232 FGLCTGLKKAHRTEFYRNLTHNPPSDFCKFGCCFSSFPWLRYCREQKVLSLSPLLNPLCFRCICI 296

  Fly   269 --------------------------------------------VGTPDYIAPELLQTISTYKLS 289
                                                        ||||||||||:.......||
Human   297 FFLWRAFFPRDYNSILLKLAFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKL- 360

  Fly   290 KSMHDVSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVS 354
                       ||:||:|:|.||::....||..:...|||.|::      :.||.:.||.::.:|
Human   361 -----------CDWWSLGVIMYEMLIGYPPFCSETPQETYRKVM------NWKETLVFPPEVPIS 408

  Fly   355 VNYRNLIESLVTNPSKRL---SYERIKNHPFFSEIPWGSIRSQVPPIIP-TVRSDDDTSNFEDGI 415
            ...::||.....:...|:   ..|.||.||||..:.|..||.: |..|| .::|.||||||:|
Human   409 EKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRER-PAAIPIEIKSIDDTSNFDD-- 470

  Fly   416 RHKTRREQGVAKKSLTTNMKSNDFSGKDLPFIGYSFVHME 455
                ..|..:.:.  ..|....|:..||..|:.|::...|
Human   471 ----FPESDILQP--VPNTTEPDYKSKDWVFLNYTYKRFE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	132/439 (30%)
		S_TKc	113..383	CDD:214567	107/367 (29%)
		Smc	487..1222	CDD:224117
		CNH	1503..1774	CDD:279162
STK38L	XP_024304657.1	STKc_NDR2	87..509	CDD:270776	133/445 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920