DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and NBPF11

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_001095133.3	Gene:	NBPF11 / 200030	HGNCID:	31993	Length:	865	Species:	Homo sapiens

Alignment Length:	914	Identity:	179/914 - (19%)
Similarity:	347/914 - (37%)	Gaps:	233/914 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 WSKKEATITDLLRLNRQKYEEAKIASEQRYEKQLADKKQELASTLQK---------LDARELEFN 606
            ||.::|.: ::|.:|            ::...|||:.||:..:..::         |..|:.::
Human     8 WSSEKAEM-NILEIN------------EKLRPQLAENKQQFRNLKERCFLTQLAGFLANRQKKY- 58

  Fly   607 AKFEECKHL-SMKLQNYKDMLQQIKEQNLKSETNHEEQRRQ---MAELYEQKLTDLRKKVRDSQD 667
             |:||||.| ...|:|.:    |.||:.|..:....|:.||   :....|::||.||:|:|:.:|
Human    59 -KYEECKDLIKFMLRNER----QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 118

  Fly   668 TNRRMTMEIKEIRTELDESISSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKL 732
            .:|.:...::.:.|..:...|..:..||......|..:.::::|:.|   |:|...|.|::|...
Human   119 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPE---NDEDEDEDVQVEEDE 180

  Fly   733 QLKENET-QEV-RAECHRLERELQLAECRCQLAES-SLATQVSPYETAPGSLTELNAIEDQLRAD 794
            ::.|:.. :|| :||..::..: .|.||....:.| .....:.|::.     .::...||::.:.
Human   181 KVLESSAPREVQKAEESKVPED-SLEECAITCSNSHGPCDSIQPHKN-----IKITFEEDKVNSS 239

  Fly   795 LLAAKESENHQKGRADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLE 859
            |:..:||.:  .|..|.|..|...             .||.|
Human   240 LVVDRESSH--DGCQDALNILPVP-------------GPTSS----------------------- 266

  Fly   860 DKLAAVREQMIVER--QAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQ 922
                |....|:|..  .::..|.:::.::.::|...|:|||...|.:   :::....|.|...|:
Human   267 ----ATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSL---KEKCFVTQVACFLAK 324

  Fly   923 RMLKTSQEETRQRESRIEELKQELAAAKRDVLKEHRQW-EKAEQERMKCKSEIIEHLANVHRLEQ 986
                      :|.:.:.||.|..:    :.:|:..||: |:...|::|...|:.::...||..|:
Human   325 ----------QQNKYKYEECKDLI----KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQER 375

  Fly   987 QETELRQKLRQIQSRFDGVTLEQKNTIRELQEEREKSRKANDSCLVL----QKELKQLTDNFQRL 1047
            :.|:||:|||                     |.|:.||..|:....|    :.:..|..|..::|
Human   376 ELTQLREKLR---------------------EGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQL 419

  Fly  1048 KYACSITDSQLTEVETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQ 1112
            ...|.:...                         |.:||...||...|...|:...|..::.:..
Human   420 AEGCRLAQH-------------------------LVQKLSPENDNDDDEDVQVEVAEKVQKSSSP 459

  Fly  1113 RAQVLASE-------IDELRL-----------NLKEQQKKLVAQQDQLVEQTNALFATQERAELL 1159
            |....|.|       ::|..:           |...::.|:..::|: |:.|  |..:....|..
Human   460 REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDK-VDST--LIGSSSHVEWE 521

  Fly  1160 DGQNANYEAQTADSNREMV------SLKE-ENARILSELFHKKEEVGNLQAE-IRGLESAQANLH 1216
            |..:...|.::.|...|..      :|:| |...:..|.:.:.....::..| :...:|..:..|
Human   522 DAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFH 586

  Fly  1217 AEIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQLKVEDLSA---KKKKTLADKLFGSSH 1278
            :         .|::|..:..||      .:|:    :.|:|.||..|   :..:.|.|:
Human   587 S---------LEEQQVCMAVDI------GRHR----WDQVKKEDQEATGPRLSRELLDE------ 626

  Fly  1279 TNKENVSPNDVESSI--------LYRALKEELKREQKMNSLLKEQLAQLNGTATLRSPRKSAAVN 1335
              ||   |..::.|:        :|..|.:..:..:....:|::|  ::.....:....|...|.
Human   627 --KE---PEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQ--RIGLAVDMDEIEKYQEVE 684

  Fly  1336 GDSDAPKQRPVSIAALPRSPQKQQQPLKRTTS----QVELKTTAEKPTKVTIENQAHHRFELALQ 1396
            .|.|....|........:.|:..|..|.|..|    .:||....: |.:..:.:.......|||.
Human   685 EDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQ-PYRSAVYSLEEQYLGLALD 748

  Fly  1397 ESKV 1400
            ..::
Human   749 VDRI 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	143/719 (20%)
		CNH	1503..1774	CDD:279162
NBPF11	NP_001095133.3	SbcC	<11..>401	CDD:223496	106/497 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..200		12/41 (29%)
		DUF1220	181..240	CDD:399619	12/64 (19%)
		DUF1220	450..511	CDD:399619	10/63 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..475		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..567		8/46 (17%)
		DUF1220	540..596	CDD:399619	9/64 (14%)
		DUF1220	609..671	CDD:399619	13/74 (18%)
		DUF1220	682..747	CDD:399619	13/65 (20%)
		DUF1220	757..821	CDD:399619
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	829..865
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000