DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sti and Rock1

DIOPT Version :9

Sequence 1:NP_001261768.1 Gene:sti / 39429 FlyBaseID:FBgn0002466 Length:1858 Species:Drosophila melanogaster
Sequence 2:NP_033097.1 Gene:Rock1 / 19877 MGIID:107927 Length:1354 Species:Mus musculus


Alignment Length:1651 Identity:400/1651 - (24%)
Similarity:683/1651 - (41%) Gaps:459/1651 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 LLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLV 130
            |||....|..:.|...|:| ::||..|:::::..|.:.|.||:.|:|:.:..:||:|.||.|.||
Mouse    30 LLDGLDALVYDLDFPALRK-NKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLV 93

  Fly   131 VERQTNDIYAMKKIKK-SVVTTSQVK---EERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPG 191
            ..:.|..:||||.:.| .::..|...   ||||||:..||.|::.|.|||||:..||:|||||||
Mouse    94 RHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPG 158

  Fly   192 GDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAA 256
            |||::|||.: ...|..||||.||:.:||..:|.||::|||:||:|:|:|:.||:||||||....
Mouse   159 GDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMK 222

  Fly   257 LDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFH 321
            ::::|.|...:.|||||||:||:|::        ...|......||:||:|:..||::...|||:
Mouse   223 MNKEGMVRCDTAVGTPDYISPEVLKS--------QGGDGYYGRECDWWSVGVFLYEMLVGDTPFY 279

  Fly   322 EDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRL---SYERIKNHPFF 383
            .|::..|||||::|      |..::||.|..:|...:|||.:.:|:...||   ..|.||.|.||
Mouse   280 ADSLVGTYSKIMNH------KNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFF 338

  Fly   384 --SEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPF 446
              .:..|.::|..|.|::|.:.||.|||||:|....|...|.....|:         |.|..|||
Mouse   339 KNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKA---------FVGNQLPF 394

  Fly   447 IGYSF---------VHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKT 502
            :|:::         .:..::..|:..|:.|||.|::.:.||:.:.:....||.::   :|..| |
Mouse   395 VGFTYYSNRRYLPSANASENRSSSNVDKSLQESLQKTIYKLEEQLHNEMQLKDEM---EQKCR-T 455

  Fly   503 DNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQ 567
            .|            .||.:|:||                    :|||.              |::
Mouse   456 SN------------LKLDKIMKE--------------------LDEEG--------------NQR 474

  Fly   568 KYEEAKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEE----CKHLSMKLQNYKDMLQQ 628
            :..|:.::..:: ||.|             |..|..|:..|.|:    .:::..::...||.|:.
Mouse   475 RNLESAVSQIEK-EKML-------------LQHRINEYQRKVEQENEKRRNIENEVSTLKDQLED 525

  Fly   629 IKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKS- 692
            :::.:            |.::|..:|||.|:|::.::.|.          :|||.|.::...|| 
Mouse   526 LRKAS------------QTSQLANEKLTQLQKQLEEANDL----------LRTESDTAVRLRKSH 568

  Fly   693 TQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAECHRLERELQLAE 757
            |:.:|:.::      |..||.|:...|             ::.||...:...:.:          
Mouse   569 TEMSKSISQ------LESLNRELQERN-------------RILENSKSQADKDYY---------- 604

  Fly   758 CRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQM 822
                                            ||:|.|.|.:....|.......||..:|.|::.
Mouse   605 --------------------------------QLQAVLEAERRDRGHDSEMIGDLQARITSLQEE 637

  Fly   823 LERFNEQSLSPTKSHSSRKQEGE--TVGDML---ERQNEKLEDKLAAVREQMIVERQAARTANLS 882
            ::..         .|:..:.|||  ...|||   |::...||..|                 |..
Mouse   638 VKHL---------KHNLERVEGERKEAQDMLNHSEKEKNNLEIDL-----------------NYK 676

  Fly   883 LWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASD----EAQRMLKTSQEETRQRESRIEELK 943
            |..::::||:.::|.|:...|:   .|:.:.::.|..    |.::.||..:|...:.|:|:.|.:
Mouse   677 LKSIQQRLEQEVNEHKVTKARL---TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVETE 738

  Fly   944 QELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETE---LRQKLRQIQSRFD-- 1003
            ::.:....|:.:..::.|...:.:.:.:.| :::||  .:|||:..:   |:.:|:......|  
Mouse   739 KQCSMLDVDLKQSQQKLEHLTENKERMEDE-VKNLA--LQLEQESNKRLLLQNELKTQAFEADNL 800

  Fly  1004 -GVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETMLKS 1067
             |:..:.|..|..|.|.:.          :|:.||.|||..::.       .:.|:.|::..|::
Mouse   801 KGLEKQMKQEINTLLEAKR----------LLEFELAQLTKQYRG-------NEGQMRELQDQLEA 848

  Fly  1068 EQERNKSQKSQLDTLHEKLRERNDQ----LTDLRKQLTTVESEKRLAEQRA---QVLASEIDELR 1125
            ||..:...|:|:..|.|::.|:|.:    :.:|:.:..|:.::..|||.:|   |:....::|..
Mouse   849 EQYFSTLYKTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAESEQLARGILEEQY 913

  Fly  1126 LNLKEQQKKLVAQQDQLV----------EQTNALFATQERAELLDGQNANYEAQTADSNREMVSL 1180
            ..|.::.||..::..|.:          |:||::..  :..|:|..:|.....:...:..|....
Mouse   914 FELTQESKKAASRNRQEITDKDHTVSRLEETNSVLT--KDIEMLRKENEELNERMRTAEEEYKLK 976

  Fly  1181 KEENARILSELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQD-------------TLAEKEQF 1232
            |||....|...|.|     |:..| |.|::...|..|||.:.:|             ...|||..
Mouse   977 KEEEINNLKAAFEK-----NISTE-RTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENR 1035

  Fly  1233 YVQRDI-----KSNATLAQHKKLIDYLQLK---------------------VEDLSAKKKKTLAD 1271
            .:|.::     |.|..:.:|:|.::.:|.:                     :|.|.| |...|:|
Mouse  1036 KLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRA-KLLDLSD 1099

  Fly  1272 KLFGSSHTNKENVSPNDVESSI---LYRALKEELKREQKMNSLLKEQLAQLNGTATLRSPRKSAA 1333
            ....:|..:.:....|..||.|   |....:..:||..     .|:|...:       |.:|...
Mouse  1100 STSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYG-----WKKQYVVV-------SSKKILF 1152

  Fly  1334 VNGDSDAPKQRPVSIAALPR----SPQKQQQPLKRTTSQV------------ELKTTAE-KPT-- 1379
            .|.:.|..:..|..:..:.:    .|..|....:..|.::            |.:...| :|.  
Mouse  1153 YNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDIEVEPVQQ 1217

  Fly  1380 --KVTIENQAHHRFELALQESKVDAVNCVVCEKAVVAGSPFW---------KCKECKDVTHRKCR 1433
              |...:|...|.|...|...   ..||..|.|      |.|         :|:.|    |.||.
Mouse  1218 GEKTNFQNHKGHEFIPTLYHF---PANCEACAK------PLWHVFKPPPALECRRC----HVKCH 1269

  Fly  1434 SNVQSHCGSTKPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIGSLVYSSDGAEDQARKEI 1498
               :.|       ....:||.|...||                        |....|.|      
Mouse  1270 ---RDH-------LDKKEDLISPCKVS------------------------YDVTSARD------ 1294

  Fly  1499 EVNCAFEVAEQQILLLGCNTGLYAYHLDSQR--LVHISGLESVSCMSICKRLAKAIMVGTVGEKL 1561
                        :|||.|:.       |.|:  :.|           :.|::.|....|.|    
Mouse  1295 ------------MLLLACSQ-------DEQKKWVTH-----------LVKKIPKNPPSGFV---- 1325

  Fly  1562 YQCDYRQLESRCQSSSSCHKPVLETS 1587
             :...|.|.:|..::.|..|.|..||
Mouse  1326 -RASPRTLSTRSTANQSFRKVVKNTS 1350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stiNP_001261768.1 PKc_like 111..452 CDD:304357 143/358 (40%)
S_TKc 113..383 CDD:214567 118/276 (43%)
Smc 487..1222 CDD:224117 153/771 (20%)
CNH 1503..1774 CDD:279162 19/87 (22%)
Rock1NP_033097.1 STKc_ROCK1 2..406 CDD:270772 158/400 (40%)
S_TKc 76..338 CDD:214567 118/276 (43%)
Interaction with FHOD1. /evidence=ECO:0000250 368..727 103/543 (19%)
Smc <422..>1097 CDD:224117 173/879 (20%)
HR1_ROCK1 489..554 CDD:212029 17/99 (17%)
SHROOM3 binding. /evidence=ECO:0000269|PubMed:22493320 707..946 55/258 (21%)
Rho_Binding 949..1014 CDD:286056 18/72 (25%)
RHOA binding. /evidence=ECO:0000250 998..1010 4/11 (36%)
Auto-inhibitory. /evidence=ECO:0000250 1115..1354 64/336 (19%)
PH_ROCK 1119..1225 CDD:269948 19/117 (16%)
C1 1229..1283 CDD:237996 18/76 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1333..1354 6/18 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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