DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sti and mrck-1

DIOPT Version :9

Sequence 1:NP_001261768.1 Gene:sti / 39429 FlyBaseID:FBgn0002466 Length:1858 Species:Drosophila melanogaster
Sequence 2:NP_504599.2 Gene:mrck-1 / 179013 WormBaseID:WBGene00006437 Length:1592 Species:Caenorhabditis elegans


Alignment Length:2008 Identity:454/2008 - (22%)
Similarity:770/2008 - (38%) Gaps:613/2008 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PPKMEPISVRTARLNNLILGKGAGVCAKPAGSASGSGIPASTRRSIVPVSTTSAAVAEAICREGL 66
            ||..:...||...|.|:.:.   |...||                            ||:..|.|
 Worm     4 PPPDDSAPVRLKTLENIYMD---GPSKKP----------------------------EALSFETL 37

  Fly    67 LDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLVV 131
            :|:...||:||...||:| ::.|||||...:.:|.:.:|||::.|||.:..:||:|.||.|.:|.
 Worm    38 IDSLICLYDECCNSTLRK-EKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVR 101

  Fly   132 ERQTNDIYAMKKIKK----SVVTTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGG 192
            .|...:|||||.:.|    ....|:..:||||::...:..|:.||.|||||..|||.||:|..||
 Worm   102 MRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGG 166

  Fly   193 DLLSLMSR---HGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNA 254
            |:|:|:|:   |.|  |.:|:||:||:.:|:.:||.:||||||:||:|:|:|..|||:|||||:.
 Worm   167 DMLTLLSKFVDHIP--ESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSC 229

  Fly   255 AALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIV--SCDYWSMGIIGYELICET 317
            ..:..||.|.|...|||||||:||:|         ::|.|.....  .||:||:||..||::..|
 Worm   230 LRILADGSVASNVAVGTPDYISPEIL---------RAMEDGRGRYGKECDWWSLGICMYEMLYGT 285

  Fly   318 TPFHEDNVHETYSKILSHCEESHLKELISFP---ADLKVSVNYRNLIESLVTNPSKRLSYERIKN 379
            |||:.:.:.:||.||:||      ::::.||   .|..||...::||..|:.:...|.....:.:
 Worm   286 TPFYSERLVDTYGKIMSH------QDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSD 344

  Fly   380 ---HPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSND--- 438
               ||||..|.|.:||...||.:|.|.|.:|||||          :..|.:...|..::...   
 Worm   345 FQLHPFFEGIDWNTIRDSNPPYVPEVSSPEDTSNF----------DVDVCEDDFTPCLQETQPPR 399

  Fly   439 ----FSGKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSL 499
                |:|..|||:|:|:.|                                              
 Worm   400 VLAAFTGNHLPFVGFSYTH---------------------------------------------- 418

  Fly   500 RKTDNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRL 564
                  ..:::||:               .||   .:|:.:....:.|.|:..|           
 Worm   419 ------GSLLSDAR---------------SLT---DEIRAIAQRCQGDAELMEK----------- 448

  Fly   565 NRQKYEEAKIASEQRYEKQLADKKQELASTL---QKLDARELEFNAKFEECKHLSMKLQNYKDML 626
                       |...:..:|.::|.||...|   |.:.|:.:..|.:.||.::....:...||.:
 Worm   449 -----------SVDGFMVELENEKAELVQKLKEAQTIIAQHVAENPRSEEDRNYESTIAQLKDEI 502

  Fly   627 QQIKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSK 691
             ||..:.|:.|...::|::...|:    :.:..||:::.::.|:::.||..||:.|||       
 Worm   503 -QILNKRLEDEALAQQQQKPKDEI----VAESEKKLKELKERNKQLVMEKSEIQRELD------- 555

  Fly   692 STQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAECHRLERELQLA 756
                       ||.:               |.::|.:|....:::.:..:               
 Worm   556 -----------NIND---------------HLDQVLVEKATVVQQRDDMQ--------------- 579

  Fly   757 ECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQ 821
                                     .||..:.|    .||..|:|....:..|::.:..|...|:
 Worm   580 -------------------------AELADVGD----SLLTEKDSVKRLQDEAEKAKKQVADFEE 615

  Fly   822 MLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAARTANLSLWKV 886
            .|:....:.::..|     |||..|:.   .|::.:.:|.|:   |:::    ||:....||   
 Worm   616 KLKEIETEKIALIK-----KQEEVTIE---ARKSVETDDHLS---EEVV----AAKNTIASL--- 662

  Fly   887 EKQLEEALSEKKLLARRME--------LTEDRIKKVQNASDEAQRMLKTSQE----ETRQRESRI 939
            :...||..:|.|.|.:||:        .:|..:|:::...:.||:||:.:.|    |.|.....|
 Worm   663 QATNEERETEIKKLKQRMDEERASHTAQSEQEMKQLEAHYERAQKMLQDNVEQMNVENRGLRDEI 727

  Fly   940 EELKQELAAAKRDVLKEHR-----QW---EKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLR 996
            |:|.|::||..|..|.|.:     .|   |||.:|.|                   |...|:...
 Worm   728 EKLSQQMAALPRGGLNEQQLHEIFNWVSEEKATREEM-------------------ENLTRKITG 773

  Fly   997 QIQSRFDGVTLEQKNTIRELQE---EREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQL 1058
            :::|..:...|...|.|:....   .|..:..|....|.||::|:...|...:||          
 Worm   774 EVESLKNNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLK---------- 828

  Fly  1059 TEVETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQVLASEIDE 1123
                ..||:.||:..:..::||                       ::|||:|.     |..|:..
 Worm   829 ----AELKNSQEQYLTSAARLD-----------------------DTEKRMAS-----LMREVAM 861

  Fly  1124 LRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNR-EMVSLKE----E 1183
            |:     |||.:....|      :|..:|..|.:|:...|.:||...:...| ||:|.:.    |
 Worm   862 LK-----QQKNIENSSD------SAFSSTMGRGDLMISMNNDYEMSNSSLMRQEMISRQSTPSYE 915

  Fly  1184 NARILSELFHK-KEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIKSNATLAQH 1247
            ||.:|.:  |: .:.|.:|:.:.:.:::|.    .....:..:..|:...:.:..||:.......
 Worm   916 NAILLHD--HQVPKRVDDLRYKQKPMKTAS----GIFSPVSISAMERGHNFERMKIKTPTKCGHC 974

  Fly  1248 KKL---IDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESS----ILYRALKE----- 1300
            ..:   :|...|..:........:.|:::..|....:|...|..::.:    ..|..|.:     
 Worm   975 TSILIGLDRQGLFCQSCQYACHVSCAERVSQSCPVPEEERRPLGIDPTRGVGTAYEGLVKTPRAG 1039

  Fly  1301 -----------------------ELKREQKMNSLLKEQLAQLNGTATLRSPRKSAAVNGDSDAPK 1342
                                   .:.|:.||..:..|....|:    :|.|  ...|.|.|:|. 
 Worm  1040 GVRKGWQTAYVVVCDFKLYLYDCTVDRQNKMQDVKNEIRLVLD----MRDP--DFTVCGVSEAD- 1097

  Fly  1343 QRPVSIAALPRSPQKQQQP--LKRTTSQV-----ELKTTAEKPTKVTIENQAHHR-FELALQESK 1399
                .|.|     ||...|  .:.||:|:     |..::::..|....|.:...| :.:||.|.|
 Worm  1098 ----VIHA-----QKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLFMAETEEEKRKWVVALSELK 1153

  Fly  1400 VDAVNCVVCEKAVVAGSPFWKCKECKDVTHRKCRSNVQSHCGSTKPTAPSADDLSSIQSVSSLTL 1464
                  .:..::.:|....:..||..|||                                  ||
 Worm  1154 ------TLLRRSKLADRKAFLVKEVFDVT----------------------------------TL 1178

  Fly  1465 DSVDVAGGTTSGGEYIGSLVYSSDGAEDQARKEIEVNCAFEVAEQQILLLGCNTGLYAYHLDSQR 1529
            .|:.||                              .|...:...:|::...:.|||...:..|.
 Worm  1179 PSIRVA------------------------------QCCAIIDRSKIVIGFSDHGLYCIEISRQL 1213

  Fly  1530 LVHISG--------LESVSCMSICKRLAKAIMVGTVGEKLYQ------CDYRQLE-SRCQSSSSC 1579
            |:.:.|        :|:|......:.|  .::||...::..:      .|.|.|: .:...:..|
 Worm  1214 LIPVGGEKENKQRCVETVEYDEAEQLL--MMIVGPAKDRHVRIVPSAALDGRDLKWIKVNDTKGC 1276

  Fly  1580 HKPVLETS---------------AIELPFANRTPS--EKWKLVLISDEAENALDSVAIAATSTRI 1627
            |...:.|:               ::.:...:|:..  :|||             .:|:..|...|
 Worm  1277 HLLAVGTNNPGGRAGFFAVAFKKSVTIFQIDRSEKRHKKWK-------------DLAMPGTPQSI 1328

  Fly  1628 VILKYDLKL---HMFK----------PVRALDTATPVTSIFFTRHSAIVSSDKFYEIDLDNYAAE 1679
            .|....|.:   |.|:          ||.:.|.:..|     .:|.::|:.              
 Worm  1329 AIFNGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAV-----LQHISLVNM-------------- 1374

  Fly  1680 EFVDLSDKSMESTAKCQPLTAVRISRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTG---FV 1741
            |...|...:.:::.:.:.:..|..|..||||.|...|::|:|.|.|||   |..|..||.   |.
 Worm  1375 EDTSLQFLNQQTSYEAKLIVNVPGSPDEYLLVFNMIGLYVNEMGRRSR---LPEVMFPTQAKYFA 1436

  Fly  1742 YRDPFLFISHYQSVQI--------VRLHRSFSKEMASGDNASEN---SESPELQRVYLPHYMSTL 1795
            |.:|:|.:.....|.|        |:.....|.:..|||.....   ::||..  |.|.:.:...
 Worm  1437 YHEPYLCVFSENEVDIFNVTLAEWVQTINLRSAKPLSGDGILSTCLCNDSPIF--VLLQNVLQDQ 1499

  Fly  1796 LANSGDVNLYAVAIDQRPCNG---TQKIYHLDTMQAFKQKFNISMETLSSVATSVTLG 1850
            .:....|||.:.:.|.|....   |.:....|...|.:::.:|.:.|.|.....|.:|
 Worm  1500 DSIEVPVNLASGSTDGRKVTRRKFTFRTIGKDDRSASERRSHIQISTPSDFMHIVHMG 1557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stiNP_001261768.1 PKc_like 111..452 CDD:304357 142/362 (39%)
S_TKc 113..383 CDD:214567 115/284 (40%)
Smc 487..1222 CDD:224117 148/766 (19%)
CNH 1503..1774 CDD:279162 66/326 (20%)
mrck-1NP_504599.2 STKc_DMPK_like 81..417 CDD:270748 142/362 (39%)
S_TKc 83..351 CDD:214567 115/284 (40%)
COG1340 494..786 CDD:224259 82/410 (20%)
C1 958..1007 CDD:237996 5/48 (10%)
PH_MRCK 1016..1159 CDD:269949 30/164 (18%)
CNH 1182..1494 CDD:214481 73/380 (19%)
PBD 1544..1582 CDD:197628 4/14 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22988
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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