Protein Alignment sti and F59A6.5

DIOPT Version :9

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: NP_494921.1
• Gene: F59A6.5 / 173864
• WormBaseID: WBGene00019087
• Length: 1286
• Species: Caenorhabditis elegans
• Alignment Length: 1428
• Identity: 277/1428 - (19%)
• Similarity: 549/1428 - (38%)
• Gaps: 351/1428 - (24%)

  Fly   538 KTLQSSAKIDEEMWSKKEA---TITDLLRLNRQK-YEEAKIASEQRYEKQLADKKQELASTLQKL 598
            |.:..:..|.:::.|:::|   |:.|...||... .|::|..|.|.             :.:.:.
 Worm    49 KRVLDAENIIQDLRSERDALHETLVDKAGLNESVIIEQSKRVSTQE-------------TRIYRR 100

  Fly   599 DARELEFNAKFEE---------CKHLSMKLQNYKDMLQQIKEQNLKSETNHEEQRRQMAELYEQ- 653
            |...||.:.|..:         |..|.|:.|..::.:|:.::...::||..|..|.::..|.::
 Worm   101 DVNLLEDDLKHHQSQIRILQNKCSTLEMEKQTLQETIQRAQDDKKETETELESSRSRLHVLEKEL 165

  Fly   654 --KLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQEAKNATERNIEEILRRLNEEIA 716
              |..|:....:|..|.|..:|....|..|:|.|:       ...|.|.|..:|:....:.|...
 Worm   166 SAKANDIFMVTKDLHDKNEELTSFRMEYVTKLSEA-------NREKKALEEKLEKYKNDMKENDR 223

  Fly   717 SNNELHAEKVKLETKLQLKENETQEVRAECHRLERELQLAECRCQLAESSLATQVSPYETAPGSL 781
            .:.||:.|:|           .||.|.:|..:|....:.               ::|.......:
 Worm   224 KSLELNKEQV-----------TTQNVLSEVRQLSAHFEF---------------LTPVRKNASKI 262

  Fly   782 TELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGET 846
            .||:... ||.|.::  :||.|..|.:.:.|...::...::::..||:.....::.::...:.|.
 Worm   263 RELDEYH-QLSAKVI--EESMNDLKIKNETLTKELSDKTELVKMKNEELEDLRQTTTASLGDSEQ 324

  Fly   847 VGDMLERQNEKLEDKLAAVREQMIVERQAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRI 911
            ....|..:|.||..:.|.:|.:::..|:.....:....::||:.::||::              :
 Worm   325 ATKYLHEENMKLTRQKADIRCELLEARRKVEGFDKLKQELEKERDDALAD--------------V 375

  Fly   912 KKVQNASDEAQRMLKTSQEETRQRESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIE 976
            :|::......:|.|::......:|:.:|||||.::.:           :|..:::....|:|:
 Worm   376 QKIREVKRNVERELQSLTSLMAERDEQIEELKTKMFS-----------FEMIKKDHESAKNEL-- 427

  Fly   977 HLANVHRLEQQETELRQKLRQIQSRFDGVTL----EQKNTIRELQEEREKSRKANDSCLVLQKEL 1037
                        :..::||.|:     |..|    :|.:|.:.|:|..|.||:         :.:
 Worm   428 ------------SRTQEKLDQM-----GKHLIMADQQCSTFKSLKESAEGSRR---------RAI 466

  Fly  1038 KQLTDNFQRLKYACSITDSQLTEVETMLKSEQE------RNKSQKSQLDTLHEKLRERNDQLTDL 1096
            :|..:...|::      |.| |.:|:..|.|||      .|..|..:::.:.|:::|.:   .|.
 Worm   467 EQCNEMVVRIR------DLQ-TSLESQRKVEQEVEMLKAENSRQAKKIEFMKEEIQEVH---LDY 521

  Fly  1097 RKQLTTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDG 1161
            |::|:      ||||:...  ..:.|.|||.|.::..:|.:.:..:.|    :.|..::.:|:..
 Worm   522 RQELS------RLAEKTKG--KEDADHLRLTLSQRDSELRSAKKTIQE----VKADNQKVQLMLV 574

  Fly  1162 QNANYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTL 1226
            :...::.:..:.|   |.|::..|..|:::...|....|.|.....||...|....::|.|::.|
 Worm   575 EVRQHQEKILEEN---VRLRKGMADALAKIEEYKRSWQNSQETCERLERESATKEDKLDKLEEEL 636

  Fly  1227 AEKEQFYVQRDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVES 1291
            .||:|           .:|:.|:|:.||..:::....|:.|      .|...|....||  ::::
 Worm   637 QEKKQ-----------QIAESKELVTYLHSQIDAKQTKQPK------LGRRSTLLSTVS--EMDT 682

  Fly  1292 SILYRALKEELKREQKMNSL---LKEQLAQLNGTATLRSPRKSAAVNGDSDAPKQRPVSIAALPR 1353
            |:..|..:|....|::..:|   |.|:..||..:...:|...:..|
 Worm   683 SVYMREAEEVRALEEQRQALMSNLAEKRRQLVDSKKSQSTANTTIV------------------- 728

  Fly  1354 SPQKQQQPLKRTTSQVELKTTAEKPTKV-----TIENQAHHRFELALQESKVDAVNCVVCEKAVV 1413
                       ||:..|:..:::..:::     |:.:...|::: |.:...|.::.|.:|...:.
 Worm   729 -----------TTTTTEISKSSQSASELSNRQGTMRHDIPHKWK-AFRHVGVLSMKCSLCFVGIS 781

  Fly  1414 AGSPFWKCKECKDVTHRKCRSNVQSHCG---------STKPTAPSADDLSSIQSVSSLTLDSVDV 1469
            |.:...||..|....|..|...|.:.||         ....|..|:..:|..:....|.:...|:
 Worm   782 AFAKAKKCSHCDVHVHASCAPRVNNTCGMPLQCATYYRENHTTVSSSGVSEGRMNGWLRVYRDDM 846

  Fly  1470 AGGTTSGGEYIGSLV---------YSSDGAEDQ----------------ARKEIEVNC------- 1502
            .|.|     :|.|..         |::|||:.:                ..:|:.|:|
 Worm   847 TGST-----WIASWAMMDLTRISFYTNDGADLEKPFFSIDLNKEQWVLRTGQEMPVDCDDSMRAN 906

  Fly  1503 ---------------------------AFEVAEQQILLLG----------C-------------- 1516
                                       ..:.|:::.::|.          |
 Worm   907 NVLMIKMPRRCLYILAPSQPSARRWAECLQTAQRKRMMLNSKESSIAEFTCLLVLNSPNNLKIFK 971

  Fly  1517 ------------NTGLYAYHLDSQR-LVHISGLESVSCMSICKRLAKAIMVGTVGEKLYQCDYRQ 1568
                        .|||:...:...| .:.|:|..||:.:.|...:....||.....:|.......
 Worm   972 AYTIEDWILFATQTGLFFTSISQPRNPMRIAGPNSVTSLEIMAEIKCVAMVANSSGQLAMIPLDS 1036

  Fly  1569 LESRCQSSSSCHKPVLETSAIELPFANRTPSEKW------KLVLISDEAENALDSVAIAATSTRI 1627
            |....||:....:|.:      ||........|:      :.:||||:              |.:
 Worm  1037 LILAMQSTQPSIRPEI------LPEFEHVHMIKYHQQNGQRFLLISDD--------------THL 1081

  Fly  1628 VILKYDLKLHMFKPVRALDTATPVTSIFFTRHSAIVSSDKFYEIDLDNYAAEEFVDLSDKSMEST 1692
            .:.||:....:|......|...|::.|.......|.:.|.||.:.||:..:.   ::|.:.:.|.
 Worm  1082 HVRKYNATRDIFSQYAKFDVPEPISFIESAPSGIIFACDTFYYVALDHQTSS---NVSARKLMSP 1143

  Fly  1693 AKCQ-PLTAVRISRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTGFVYRDPFLFISHYQSVQ 1756
            .|.: |::|..|::.|.||.:...|:||:..|.:||...:.|...|..|:|..|||:|.|..|::
 Worm  1144 NKNEFPISAQMINQNEVLLAYQNQGIFVNLHGEQSRNETIEWEKMPMEFIYTSPFLYIVHDDSIE 1208

  Fly  1757 IVRLHRSFSKEMASGDNASENSESPELQRVYLPHYMSTLLANSGDVNLYAVAIDQRPCNGTQK 1819
            |:.:..:..:.:.:.....|...:..:.|.|....:|....:|.:|:.::.|..|:..|...|
 Worm  1209 ILEISETSDRTVLAERALFECVNAHVIGRQYEGVLISVSSNDSTEVHRFSTATGQKQKNNVSK 1271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	141/709 (20%)
		CNH	1503..1774	CDD:279162	65/314 (21%)
F59A6.5	NP_494921.1	KASH_CCD	235..436	CDD:291334	44/257 (17%)
		COG1340	341..645	CDD:224259	78/392 (20%)
		C1	758..808	CDD:237996	12/50 (24%)
		PH	835..940	CDD:278594	14/109 (13%)
		PH	835..940	CDD:214574	14/109 (13%)
		CNH	965..1248	CDD:214481	66/305 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I5904
eggNOG	1	0.900	-	-		E1_KOG0976
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810