DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and let-502

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_491440.1	Gene:	let-502 / 172088	WormBaseID:	WBGene00002694	Length:	1173	Species:	Caenorhabditis elegans

Alignment Length:	1489	Identity:	360/1489 - (24%)
Similarity:	614/1489 - (41%)	Gaps:	403/1489 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVH 128
            |.|||....|.|:| |..:..|.:::..|::::..::|....||:.|.||....:||:|.||.||
Worm    20 ESLLDTITALVNDC-KIPVLMRMKSVDNFISRYERVVESLAALRMKAADFRQLKVIGRGAFGEVH 83

  Fly   129 LVVERQTNDIYAMKKIKKSVVTTSQVK--------EERDIMSIRNSEWLINLQYAFQDNDNLYLV 185
            ||...:||.:||||.:.|.    ..:|        ||||||:..||||::.|||||||..:||:|
Worm    84 LVRHTRTNTVYAMKMLNKD----DMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMV 144

  Fly   186 MEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLAD 250
            |||||||||::||:.: ...|...|||.||:..||..||.|||:|||:||:|:||...|||||||
Worm   145 MEYMPGGDLVNLMTSY-EVSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLAD 208

  Fly   251 FGNAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELIC 315
            ||....::.:|.|...:.|||||||:||:|:        ....|.......|:||:|:..||::.
Worm   209 FGTCVKMNANGVVRCSTAVGTPDYISPEVLR--------NQGQDAEFGKEVDWWSVGVFIYEMLV 265

  Fly   316 ETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRL---SYERI 377
            ..|||:.:.:..||:.|::|      |..:.||.:..:|...:::|:..::....||   |.:.|
Worm   266 GETPFYAEALVSTYTNIMNH------KTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNSVDDI 324

  Fly   378 KNHPFFSEIPW--GSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSNDFS 440
            :||.||....|  .::|...||:||:::|||||::||: |..:.|...|..:...|       |:
Worm   325 RNHKFFVNDEWTFATLREASPPVIPSLKSDDDTTHFEE-IETRDRDNAGDFQLPKT-------FN 381

  Fly   441 GKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQ--KLKTRENEISMLKQDLLRAQQSLRKTD 503
            |..|||||:::.: |.|.:            |.||:  ...:::|.|...|...: .:|.|  |:
Worm   382 GNQLPFIGFTYSN-EYSPV------------KNLLKGHGAGSKQNGIEQHKPQTV-VEQPL--TN 430

  Fly   504 NKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQK 568
            ..:..|.:.|.|..|::  :..|..|....|..|...:..||:.|...:.....|:||
Worm   431 GHASGVPEEKYEAVKME--LDSKNREFELLKDSIARNEIRAKMIENEKNSLSTKISDL------- 486

  Fly   569 YEEAKIASEQRYEKQLADKKQEL---ASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQQIK 630
                        |::|.|.|.:|   |.:..|::...:|.....|....:..:|..::|..:|:|
Worm   487 ------------ERELKDNKDKLRHGADSDAKVNELAVELRMSKEYNSEMESELSKFRDKCEQLK 539

  Fly   631 EQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQE 695
            |                         |||||           :.|:.:.:.|........|...|
Worm   540 E-------------------------DLRKK-----------SGELAQEKNETQRVFQQKKDADE 568

  Fly   696 AKNATERNIEEILRRLNEEIASNNELHAEKVKLETKL-QLKEN---ETQEVRAECHRLERELQLA 756
            |....:|:.|.:..|.||          :.|:|:..| :.|||   :....:|.....||::|.
Worm   569 AFAEIKRDYELLQTRENE----------KSVQLKKALDERKENGAYQQSVAKATDAEWERKMQF- 622

  Fly   757 ECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQ 821
                                          .|.||        |..|.::.|.:|.:|..
Worm   623 ------------------------------YEKQL--------EHANDERKREEQKRTAA----- 644

  Fly   822 MLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAARTANLSLWKV 886
               .|::       |..:||..|      :|...|.|::...:::|        ||.      .:
Worm   645 ---EFDQ-------SRVARKLAG------IEANYELLQNDYKSMKE--------ARK------DL 679

  Fly   887 EKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEELKQELAAAKR 951
            |:.|::.::||    ||:|:   |::::.::.:..:|:|..
Worm   680 ERDLQDVITEK----RRLEI---RVEQLMDSRNTDERVLSL------------------------ 713

  Fly   952 DVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQSRFDGVTLEQKNTIREL 1016
                              |:.|::|          .:.|.:.|...::.:.||..       .||
Worm   714 ------------------CQDELVE----------SQEEAKYKEDGLRGKIDGFK-------HEL 743

  Fly  1017 QEEREKSRKANDSCLVLQKE---LK-QLTDNFQRLKYACSITDSQLTEVETMLKSEQERNKSQKS 1077
            :.|:.|::...::.||..||   || ::.:..||.|:..:..|..|..:||.|...::::|.:.|
Worm   744 ENEKMKTQTLEENLLVADKERGMLKMEVQELMQRHKWEITNKDQTLKHLETQLDEIKQQSKIESS 808

  Fly  1078 QLDTLHEKLRERNDQLT--DLRKQLTTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKLVAQQD 1140
            :        :|.||:.|  ||||                          :|:|::..||.|..:
Worm   809 E--------QESNDKQTIADLRK--------------------------KLDLEKAHKKAVINK- 838

  Fly  1141 QLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSLKEEN---ARILSELFHKKEEVGNLQ 1202
              :|:..|     :|..|..|:....::......||:::|::|.   ::.::.||::.::    |
Worm   839 --LEEEMA-----KRQPLKKGEKGVTKSALIKKEREIMALEQERDTMSKRIAALFYENDK----Q 892

  Fly  1203 AE-----IRGLESAQANLHAEIDSLQDTLAEKE---QFYVQRDIKSNATLA-----QHKKLIDYL 1254
            ||     |:.:::.|..|..|:...::.||.:.   ::..:|.:.|...:.     ||.::..:|
Worm   893 AEHFNIAIQDMQTTQDALRDELKECKEELANRNVNTRYEDKRSLDSREGIPSSLSNQHIQMEGWL 957

  Fly  1255 QLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILYRALKEELKREQKMNSLLKEQLAQL 1319
            .|:  |.:.|.:|......|.:.:.....:..::...|::.      |.....|..:.....|.|
Worm   958 SLR--DNTKKSRKPKWTNCFVALNEYSFTIYVDEKAVSVIL------LIEAGAMAHVRHVTAADL 1014

  Fly  1320 NGTATLRSPRKSAAVNGDSDAPKQRPVSIAALPRSPQKQQQPLKRTTSQVELKTTAEKPTKVTIE 1384
            ......:.|:....:..|:.....|..|.:.|......:::..||...|               |
Worm  1015 RNVDDSQLPKIFHIMYDDASCNSSRHASNSDLSMIESFREESWKRHDFQ---------------E 1064

  Fly  1385 NQAHHRFELALQESKVDAVNCVVCEKA---VVAGSPFWKCKECKDVTHR---------KCRSNVQ 1437
            ...|.|            ..|.||.|.   ::..:|.::||.|...||:         .||.|.
Worm  1065 LSYHIR------------TFCDVCNKKLSDIIRPTPAFECKNCHFKTHKDHVAQGSLPMCRYNT- 1116

  Fly  1438 SHCGSTKP---TAPSADDLSS--------IQSVSSLTLDSVDVAGGTTSGGEYIGSLVY 1485
               |.::.   .||..|:.:.        |:|..|..:....|:....:.|....|.:|
Worm  1117 ---GLSRELVLMAPQTDNCNKWVSQLRRFIESSRSAAVSVSRVSSRRHAPGSSNSSTIY 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	143/353 (41%)
		S_TKc	113..383	CDD:214567	116/280 (41%)
		Smc	487..1222	CDD:224117	144/755 (19%)
		CNH	1503..1774	CDD:279162
let-502	NP_491440.1	PKc_like	41..393	CDD:304357	148/378 (39%)
		S_TKc	68..330	CDD:214567	116/280 (41%)
		PH-like	951..1056	CDD:302622	16/112 (14%)
		C1	1060..1112	CDD:197519	14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920