DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sti and Cdc42bpb

DIOPT Version :9

Sequence 1:NP_001261768.1 Gene:sti / 39429 FlyBaseID:FBgn0002466 Length:1858 Species:Drosophila melanogaster
Sequence 2:XP_006240624.1 Gene:Cdc42bpb / 113960 RGDID:621753 Length:1730 Species:Rattus norvegicus


Alignment Length:2019 Identity:486/2019 - (24%)
Similarity:769/2019 - (38%) Gaps:658/2019 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 EGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVH 128
            |.|||....||.||....| :||:.:|||:...:|..:..:.::::.:||.|..:||:|.||.|.
  Rat    28 ETLLDVLVCLYTECSHSAL-RRDKYVAEFLEWAKPFTQLVKDMQLHREDFEIIKVIGRGAFGEVA 91

  Fly   129 LVVERQTNDIYAMKKIKK----SVVTTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYM 189
            :|..:.|..|||||.:.|    ....|:..:||||::...:.:|:..|.|||||.:.|||||:|.
  Rat    92 VVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENYLYLVMDYY 156

  Fly   190 PGGDLLSLMSR-HGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGN 253
            .|||||:|:|: .....||:||||:.|:.:|:.::|::.||||||||:|:|:|..|||:|||||:
  Rat   157 VGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGS 221

  Fly   254 AAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHD-VSRI-VSCDYWSMGIIGYELICE 316
            ...::.||.|.|...|||||||:||:||         :|.| :.:. ..||:||:|:..||::..
  Rat   222 CLKMNDDGTVQSSVAVGTPDYISPEILQ---------AMEDGMGKYGPECDWWSLGVCMYEMLYG 277

  Fly   317 TTPFHEDNVHETYSKILSHCEESHLKELISFPADL-KVSVNYRNLIESLVTNPSKRL---SYERI 377
            .|||:.:::.|||.||::|      :|...||:.: .||...::||:.|:.:..:||   ..|..
  Rat   278 ETPFYAESLVETYGKIMNH------EERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDF 336

  Fly   378 KNHPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNF---EDGIRHKTRREQGVAKKSLTTNMKSNDF 439
            |.|.||..:.|.:||:...|.||.|.|..|||||   :|.:|:......|          ....|
  Rat   337 KKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNIEILPPG----------SHTGF 391

  Fly   440 SGKDLPFIGYSFVHME--------KSAISATT---DEKLQEKLKELLQKLKTRENEISMLKQDLL 493
            ||..|||||::|....        ||.|.:.|   ||.:|..|:..|| ::..|..|..|:|:.|
  Rat   392 SGLHLPFIGFTFTTESCFSDRGSLKSMIQSNTLTKDEDVQRDLENSLQ-IEAYERRIRRLEQEKL 455

  Fly   494 RAQQSLRKTDNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATI 558
            ...   ||....:|.|.......:.|....::|         :||      :::||         
  Rat   456 ELS---RKLQESTQTVQSLHGSTRALGNSNRDK---------EIK------RLNEE--------- 493

  Fly   559 TDLLRLNRQKYEEAKIASEQRYEKQLADK---KQELASTLQKLDARELEFNAKFEECKHLSMKLQ 620
                 |.|.|   :|:|...|.|:||.|.   :||...:.|:|...|.::....:|.:.|     
  Rat   494 -----LERMK---SKMADSNRLERQLEDTVTLRQEHEDSTQRLKGLEKQYRLARQEKEEL----- 545

  Fly   621 NYKDMLQQIKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDE 685
             :|.:::  ..:.|||:|                     |:::|:....:|...|..|       
  Rat   546 -HKQLVE--ASERLKSQT---------------------KELKDAHQQRKRALQEFSE------- 579

  Fly   686 SISSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQ-------EVR 743
                                     |||.:|   ||.::|.|:..:|:.||.|.:       .:|
  Rat   580 -------------------------LNERMA---ELRSQKQKVSRQLRDKEEEMEVAMQKIDSMR 616

  Fly   744 AECHRLERELQLAECRCQ--LAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQK 806
            .:..:.|:..:..|.|.:  :||:|.                    |.:||      :.||:..|
  Rat   617 QDIRKSEKSRKELEARLEDAVAEASK--------------------ERKLR------EHSESFSK 655

  Fly   807 GRADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNE------KLEDKLAAV 865
            ....:|:||..                       ||.|...|..||.|.|      :||.|:...
  Rat   656 QMERELETLKV-----------------------KQGGRGPGATLEHQQEISKIRSELEKKVLFY 697

  Fly   866 REQMIVERQAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQE 930
            .|: :|.|:|:..  |.:..|:|::.|:.|.:..|.:.:.:.:|:::|                 
  Rat   698 EEE-LVRREASHV--LEVKNVKKEVHESESHQLALQKEVLMLKDKLEK----------------- 742

  Fly   931 ETRQRESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKL 995
            ..|:|.|.:|    |...|.:|..:..|.....|.:::..::|.:  .:.|.:|..|..:|..:|
  Rat   743 SKRERHSEME----EAIGAMKDKYERERAMLFDENKKLTAENEKL--CSFVDKLTAQNRQLEDEL 801

  Fly   996 RQIQSRFDGVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTE 1060
            :.:.|:.:.|. ..:..|.|:                    ::.::|......|..::......|
  Rat   802 QDLASKKESVA-HWEAQIAEI--------------------IQWVSDEKDARGYLQALASKMTEE 845

  Fly  1061 VETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQVLASEIDELR 1125
            :||:      |:.|..|:  ||....:.|..|..|:         ..||..|.|  |.:||    
  Rat   846 LETL------RSSSLGSR--TLDPLWKVRRSQKLDM---------SARLELQSA--LEAEI---- 887

  Fly  1126 LNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSLKEENARILSE 1190
                 :.|:||.::.:.|:.|:..|.::.:..         ||:..:...||.|||         
  Rat   888 -----RAKQLVHEELRKVKDTSLAFESKLKES---------EAKNRELLEEMQSLK--------- 929

  Fly  1191 LFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQ 1255
               |:.|           |..:|:...::...||.:.|    |.     :.|.||          
  Rat   930 ---KRME-----------EKFRADTGLKLPDFQDPIFE----YF-----NTAPLA---------- 961

  Fly  1256 LKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILYRALKEELKREQKMNSLLKEQLAQLN 1320
               .||      |..|.|..||            .||:|  ||.|:........:    |.::|:
  Rat   962 ---HDL------TFRDSLSSSS------------ASSLL--ALWEDTSSASDQET----QASKLD 999

  Fly  1321 GTATLRSPRKSAAVN----GDSDAPKQRPVSIAALPRSPQKQQQPLKRTTSQVELKTTAEKPTKV 1381
                 .||..|.|.:    .|:...:|||.::            ||..|.:   |.....||.. 
  Rat  1000 -----LSPSVSVATSTEQQEDAARSQQRPSTV------------PLPNTQA---LAMAGPKPKA- 1043

  Fly  1382 TIENQAHHRFELALQESKVDAVNCVVCEKAVVAGSPFWKCKECKDVTHRKCRS------------ 1434
                   |:|.:....|.....:|......::...  :.|:.|....|..|:.            
  Rat  1044 -------HQFSIKSFPSPTQCSHCTSLMVGLIRQG--YACEVCAFSCHVSCKDSAPQVCPIPPEQ 1099

  Fly  1435 -------NVQSHCGST--------KPT----------APSAD------DLSSIQS-----VSSLT 1463
                   :||...|:.        |||          |...|      ||...:|     ::|..
  Rat  1100 SKRPLGVDVQRGIGTAYKGYVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQV 1164

  Fly  1464 LDSVDVAGGTTSGGEYIGSLVYSSDGAEDQARKEIEVNCAFEVAEQQI----------------- 1511
            ||..|        .|:..|.|.:||......|   ::.|.|.|....:                 
  Rat  1165 LDLRD--------DEFAVSSVLASDVIHATRR---DIPCIFRVTASLLGSPSKTSSLLILTENEN 1218

  Fly  1512 -------LLLGCNTGLYAYHLDSQRLVHISGLESVSCMSICKR-LAKAIMVG---TVG--EKLYQ 1563
                   :|.|....|:...|.|| :||::.....|.:.:.|. ||.||:.|   .||  |.||.
  Rat  1219 EKRKWVGILEGLQAILHKNRLRSQ-VVHVAQEAYDSSLPLIKTVLAAAIVDGDRIAVGLEEGLYV 1282

  Fly  1564 CDY-RQLESRCQSSSSCHKPVLETSAIELPFANRTPSEKWKLVLIS-------------DEAENA 1614
            .:. |.:..|   ::.|.|    ...|||     .|.||..|:|..             |.||.:
  Rat  1283 IELTRDVIVR---AADCKK----VYQIEL-----APKEKLILLLCGRNHHVHLYPWTSFDGAEAS 1335

  Fly  1615 LDSVAIAATSTRIVILKYDLKLHMFKPVRALDTAT----PVTSIFFTRHSAIVSSD--------- 1666
                            .:|:||...|..:.:.|.|    ..|.:|......::..:         
  Rat  1336 ----------------NFDIKLPETKGCQLIATGTLRKSSSTCLFVAVKRLVLCYEIQRTKPFHR 1384

  Fly  1667 KFYEI------------------------------------DLDNYAAEEFVDLSDKSMESTAKC 1695
            ||.||                                    ||.|.|......||.:|.::    
  Rat  1385 KFNEIVAPGHVQWMAMFKDRLCVGYPSGFSLLSIQGDGQPLDLVNPADPSLAFLSQQSFDA---- 1445

  Fly  1696 QPLTAVRISRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTG--------FVYRD---PFLFI 1749
              |.||.:..:||||||:..|::||..|.|||..:|.|..||..        .||.:   ....:
  Rat  1446 --LCAVELKSEEYLLCFSHMGLYVDPQGRRSRTQELMWPAAPVACSCSSSHVTVYSEYGVDVFDV 1508

  Fly  1750 SHYQSVQIVRLHR-------------------------SFSKEMASGDNASENSES--------- 1780
            ...:.||.:.|.|                         .||..:.:..:.|:||:.         
  Rat  1509 RTMEWVQTIGLRRIRPLNSDGSLNLLGCEPPRLIYFKNKFSGTVLNVPDTSDNSKKQMLRTRSKR 1573

  Fly  1781 ------PELQRVYL-------PHYMSTLLANSGDVNLYAVAIDQRPCNGTQKIYHL-----DTMQ 1827
                  ||.:|:..       |...|.:::|..:.|..|   ...|.:|.|.:..|     .|.|
  Rat  1574 RFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVA---HMGPGDGMQVLMDLPLSAAPTAQ 1635

  Fly  1828 AFKQ 1831
            ..||
  Rat  1636 EEKQ 1639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stiNP_001261768.1 PKc_like 111..452 CDD:304357 142/354 (40%)
S_TKc 113..383 CDD:214567 115/280 (41%)
Smc 487..1222 CDD:224117 147/752 (20%)
CNH 1503..1774 CDD:279162 84/399 (21%)
Cdc42bpbXP_006240624.1 STKc_MRCK_beta 3..411 CDD:270774 158/408 (39%)
S_TKc 76..342 CDD:214567 115/280 (41%)
TPH 419..786 CDD:290579 111/541 (21%)
KELK 528..606 CDD:292424 26/141 (18%)
DMPK_coil 878..939 CDD:117396 21/103 (20%)
C1 1044..1093 CDD:237996 8/50 (16%)
PH_MRCK 1103..1237 CDD:269949 27/144 (19%)
CNH 1263..1529 CDD:279162 69/299 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22988
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.920

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