DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and STK38

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_001292031.1	Gene:	STK38 / 11329	HGNCID:	17847	Length:	465	Species:	Homo sapiens

Alignment Length:	436	Identity:	135/436 - (30%)
Similarity:	221/436 - (50%)	Gaps:	85/436 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EGLLDAFCLLYNECDKDTLKK--RDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGN 126
            |||.|         ::..|::  ..|...||:        ..::.|:..:||....:||:|.||.
Human    55 EGLKD---------EEKRLRRSAHARKETEFL--------RLKRTRLGLEDFESLKVIGRGAFGE 102

  Fly   127 VHLVVERQTNDIYAMKKIKKSVVTTSQ----VKEERDIMSIRNSEWLINLQYAFQDNDNLYLVME 187
            |.||.::.|..:||||.::|:.:...:    ::.||||:...:|.|::.:.|:|||..||||:||
Human   103 VRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIME 167

  Fly   188 YMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFG 252
            ::||||:::|:.:.....|:..:||:||..:|:.::|::|::||||||:|:|:|..||:||:|||
Human   168 FLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFG 232

  Fly   253 ----------------------------------NAAALDRDGHVLSLSPVGTPDYIAPELLQTI 283
                                              .|....|:...|:.|.||||||||||:....
Human   233 LCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT 297

  Fly   284 STYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFP 348
            ...||            ||:||:|:|.||::....||..:...|||.|::      :.||.::||
Human   298 GYNKL------------CDWWSLGVIMYEMLIGYPPFCSETPQETYKKVM------NWKETLTFP 344

  Fly   349 ADLKVSVNYRNLIESLVTNPSKRL---SYERIKNHPFFSEIPWGSIRSQVPPIIPTVRSDDDTSN 410
            .::.:|...::||.........|:   ..|.||::.||..:.|..||.:...|...::|.|||||
Human   345 PEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSN 409

  Fly   411 FEDGIRHKTRREQGVAKKSL-TTNMKSNDFSGKDLPFIGYSFVHME 455
            |::      ..|..:.|.:: |:|....|:..||..||.|::...|
Human   410 FDE------FPESDILKPTVATSNHPETDYKNKDWVFINYTYKRFE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	125/382 (33%)
		S_TKc	113..383	CDD:214567	101/310 (33%)
		Smc	487..1222	CDD:224117
		CNH	1503..1774	CDD:279162
STK38	NP_001292031.1	Interaction with S100B. /evidence=ECO:0000269\|PubMed:14661952	62..87		5/32 (16%)
STK38	NP_001292031.1	STKc_NDR1	87..462	CDD:270777	126/387 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920