DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and dmpk

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_009303323.1	Gene:	dmpk / 101886625	-ID:	-	Length:	600	Species:	Danio rerio

Alignment Length:	578	Identity:	181/578 - (31%)
Similarity:	297/578 - (51%)	Gaps:	96/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LGKGAGVCAKPAGSA------SGSGIPASTRRSIVPVSTTSAAVAEA-ICREGLLDAFCLLYNEC 77
            :.:|.|    |:|:|      .|:|                 .:||. :..:.|||....:|.|.
Zfish     1 MSRGPG----PSGAAHLQDREPGAG-----------------GLAEGPVGLQTLLDLLVGVYQEF 44

  Fly    78 DKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLVVERQTNDIYAMK 142
            ....| :|::::..|:....|::.:.:|.|::.:||.|..:||:|.|..|.|...|.|..:||:|
Zfish    45 CSSPL-RREKHVQRFLQWAEPLVRQVKKTRISREDFHILKVIGRGTFSEVALARMRNTQQVYAVK 108

  Fly   143 KIKK-SVVTTSQV---KEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSR-HG 202
            .:.| .::...::   :|||:::...:..|:..|.|||||:|.|||||.|..|||||:|:|: :.
Zfish   109 IMNKWDMLKRGEMACYQEEREVLLKGDRRWITELHYAFQDDDYLYLVMHYYVGGDLLTLLSKFND 173

  Fly   203 PFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAALDRDGHVLSLS 267
            ...|::|:|||||:.:|:.::|.:|||||||||:|||:...||.:|.|||:...|:.||.|.|..
Zfish   174 GLPEEMAQFYLAEMVMAIDSVHLLGYVHRDIKPDNILLTADGHARLGDFGSCLRLEDDGLVHSAV 238

  Fly   268 PVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKI 332
            .||||||::||||:.:.......|        .||:|::|:..||::..||||:.:::.|||:||
Zfish   239 AVGTPDYLSPELLRAVEAGGGYGS--------DCDWWALGVCAYEMLLGTTPFYAESISETYAKI 295

  Fly   333 LSHCEESHLKELISFPAD-LKVSVNYRNLIESLVTNPSKRL---SYERIKNHPFFSEIPWGSIRS 393
            :      |.|:...|||. ::||...|.|:.||:...|:||   .....::|||||.:.|.|:..
Zfish   296 I------HFKDYFGFPASGVQVSEPARALVCSLLXERSERLGSGGSADFRSHPFFSGLDWSSLHL 354

  Fly   394 QVPPIIPTVRSDDDTSNFE--DGIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPFIGYSF----- 451
            ..||..|.|.:..|||||:  |....:|.....|.:::..         |..|.|:|||:
Zfish   355 HPPPYRPDVSNATDTSNFDVLDDCLSETETLSDVMERAPV---------GVHLAFVGYSYTATRE 410

  Fly   452 ---------VHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKTDNKSQ 507
                     :.||...:..|....||:||.::.|..:|       :..::|.|.:|..:.:|..:
Zfish   411 TGALDRSSDIMMEIDQLQDTDSLHLQDKLDQVWQLRET-------ITAEVLSAPESPAEKNNPER 468

  Fly   508 VVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLN 565
            |  |...|.::....::|....|.      |..:.:.::::||...:|    .:|||:
Zfish   469 V--DRSTETEQSDTHVQELQRHLH------KAERRNRELEQEMAGLRE----QILRLS 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	136/365 (37%)
		S_TKc	113..383	CDD:214567	112/278 (40%)
		Smc	487..1222	CDD:224117	16/79 (20%)
		CNH	1503..1774	CDD:279162
dmpk	XP_009303323.1	PKc_like	77..406	CDD:304357	136/351 (39%)
		S_TKc	79..344	CDD:214567	112/278 (40%)
		bZIP	<482..513	CDD:304365	7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020