DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and LOC100497498

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_002938754.3	Gene:	LOC100497498 / 100497498	-ID:	-	Length:	1608	Species:	Xenopus tropicalis

Alignment Length:	2042	Identity:	459/2042 - (22%)
Similarity:	778/2042 - (38%)	Gaps:	676/2042 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RTARLNNLILGKGAGVCAKPAGSASGSGIPASTRRSIVPVSTTSAAVAEAICREGLLDAFCLLYN 75
            |...|.::|| :|      |.|...||                       :..|.|:||...|.:
Frog     6 RLKELEDMIL-RG------PQGPGIGS-----------------------LSMETLIDALICLCH 40

  Fly    76 ECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLVVERQTNDIYA 140
            .|:...| :||:|:.||:....|...:.:::|:..|||.|..:||:|.||.|.:|..:.:..|:|
Frog    41 ACNAAPL-RRDKNVTEFLAWAEPFSSKVKQMRLKRDDFEIVKVIGRGAFGEVAVVKMKGSGKIFA 104

  Fly   141 MKKIKK----SVVTTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSR- 200
            ||.:.|    ....|:..:||||::...:::|:.:|.|||.|::.|||||:|..|||||:|:|:
Frog   105 MKILHKWEMLKRAETACFREERDVLVKGDTQWIPSLHYAFHDDNYLYLVMDYYVGGDLLTLLSKF 169

  Fly   201 HGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAALDRDGHVLS 265
            .....||:|||||||:.:|:.::|::.||||||||:|:|||..|||:|||||:...:..||.|.|
Frog   170 EDRLPEDMARFYLAEMVLAIDSIHQLNYVHRDIKPDNVLIDLKGHIRLADFGSCLKMKPDGTVES 234

  Fly   266 LSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYS 330
            ...|||||||:||:||.:...|....       :.||:||:|:..|||:...|||:.:::.|||.
Frog   235 SVAVGTPDYISPEILQAMEDGKGKYG-------IECDWWSLGVSMYELLFGETPFYAESLVETYG 292

  Fly   331 KILSHCEESHLKELISFPADL-KVSVNYRNLIESLVTNPSKRL---SYERIKNHPFFSEIPWGSI 391
            ||::|  |.||:    ||:|: .||...::||:.|:....:||   ..:..|.||||:.:.|.:|
Frog   293 KIMNH--EEHLQ----FPSDITDVSEKAKDLIQRLICRKEERLGKGGIDDFKKHPFFNGVDWDNI 351

  Fly   392 RSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKS------NDFSGKDLPFIGYS 450
            |:.:||..|.|.|..|||||:            |..:|| .|:.:      |.||...|||:|::
Frog   352 RNAIPPYTPEVDSPADTSNFD------------VDDESL-KNLDTLPPNNHNGFSAHLLPFVGFT 403

  Fly   451 FV---------HMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKTDNKS 506
            |.         .:..:..|.|...:...|..:..::|..::.||..||:::
Frog   404 FTSECSLSDRGSLSCAVSSGTASSEKTTKPGQDKEQLNAKDGEIRSLKKEM-------------- 454

  Fly   507 QVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQKYEE 571
                          :|:::|                                   |.:|.::.|.
Frog   455 --------------EILQKK-----------------------------------LAVNAKEQEG 470

  Fly   572 AKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEEC-KHLSMKLQNYKDMLQQIKEQNLK 635
            ...:..|..||::...|||.                  |.| |.||       |||:::|.|.::
Frog   471 LSGSQFQSLEKEIRSLKQEK------------------ESCNKELS-------DMLERLKSQGVE 510

  Fly   636 SETNHEEQRRQMAEL--YEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQEAKN 698
            .:...|:::....||  .|:|...|..:|       .|:|..:|:...|::
Frog   511 LKAALEKKKTMQEELRGAEEKCESLNSQV-------GRLTRRLKDKEDEVE-------------- 554

  Fly   699 ATERNIEEILRRLNEEIASNNELHA--EKVKLETKLQLKENETQEVRAECHRLERELQLAECRCQ 761
            ||...:..:.:.|::...|..|:.:  |.:.||.:.|.|..|..|..|.  :...||:     |.
Frog   555 ATAEKVRLLRKNLHKAEGSRREIESQIEDLNLELEKQKKLRERSEALAT--QATEELE-----CL 612

  Fly   762 LAESSLATQVSPYETAPGSL--TELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQMLE 824
            .::.|:.:.|     ..|||  :|:.    |||.||  .:.|::|:           |:||::
Frog   613 KSQQSITSPV-----ISGSLHYSEMT----QLRTDL--ERRSQHHE-----------TELERL-- 653

  Fly   825 RFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAARTANLSLWKVEKQ 889
                     .|..:.|::|..|....|.|:..:.|.:|.::|.:|                  :.
Frog   654 ---------RKELACREEEHATETKSLRRELGERETELISLRHEM------------------EA 691

  Fly   890 LEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEELKQELAAAKRDVL 954
            |:|:|..|                              |.:..|.:|..|:|: |::...:|:.|
Frog   692 LQESLGRK------------------------------SSDRARAQEEEIQEM-QKINERERNSL 725

  Fly   955 KEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQSRFDG-VTLE-QKNTIRELQ 1017
            ||         |..|.|.|:.:.||...:|......|.::|:.:..:.|. |..| |...|.:..
Frog   726 KE---------ENKKLKQELEKVLAESDKLAASHKSLEEELQLLDVKKDSLVNWETQVTDILQWV 781

  Fly  1018 EEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETMLKSEQERNKSQKSQLDTL 1082
            .:.::||      :.||....:|||....||.:...|.|               :|:.:||...
Frog   782 NDEKQSR------VYLQALSVRLTDELDTLKNSGGQTPS---------------SKTGESQWKA- 824

  Fly  1083 HEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKLVAQQDQLVEQTN 1147
                           ::|..:|:..||..|.|         |...:|.:|        .:.|:.|
Frog   825 ---------------RRLQKLEASARLELQSA---------LEAEIKAKQ--------CIQEELN 857

  Fly  1148 ALFATQERAELLDGQNANYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAEIRGLESAQ 1212
                             .:::::.::.|::...:|||.::.:|:...:||
Frog   858 -----------------RFKSESHNTERKLQEAEEENRKLRAEVEKVREE--------------- 890

  Fly  1213 ANLHAEIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKTLADKLFGSS 1277
                    :.|..:.|.:               |.:.||.:|                     |.
Frog   891 --------AKQKAITETK---------------QQRPLIPFL---------------------SF 911

  Fly  1278 HTNKENVSPND-VESSILYR------ALKEELKREQKMNSLLKEQLAQLNGTA----TLRSPRKS 1331
            .|.|:.::..| .:::::.|      ::|.::.|.......::|...::...|    |..||.|.
Frog   912 RTEKDPINAEDQTQNNVMIRRDSRTESVKNKVNRRSAGFDTIEEASEKMKSHAFKVKTFTSPTKC 976

  Fly  1332 -----------------------AAVNGDSDAPKQRPVSIAALPRSPQKQ---QQPLKRTTSQVE 1370
                                   ..|:....||      |...|.|..|:   ..|:..:.:.:|
Frog   977 LRCTSVMIGLCRQGLCCEVCGYICHVSCSEKAP------ICPSPPSQIKKILGVDPVTGSGTALE 1035

  Fly  1371 LKTTAEKPTKVTIENQAHHRFELALQESKV---DAVNCVVCEKAVVAGSPFWKCKECKDVTHRKC 1432
            ...:..||..|   .:...:..:.|.|.||   ||  |..|..|::           :.:..|..
Frog  1036 GSLSVPKPAGV---RKGWQKAYVILSEFKVLVYDA--CPPCNTAII-----------QAIDMRDE 1084

  Fly  1433 RSNVQSHCGSTKPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIGSLVYSSDGAE------ 1491
            ..:|.|...|....|.:.|    |..:..:|...:.....|:|      .|:.:..|.|
Frog  1085 NFSVSSVLESDVIHASTKD----IPCIFRITFSQMSSPPTTSS------QLLLAETGEEMQKWVQ 1139

  Fly  1492 ------------------------DQARKEIEVNCAFEVAEQQILLLGCNTGLYAYHLDSQRLVH 1532
                                    |.|...|.......:.:|:.|.||...||:..|::...::.
Frog  1140 VLKELHGLLKGPHSQSVRVLKEAYDSALPLIRTALCATIIDQERLALGNEDGLFLLHVNKNEIMQ 1204

  Fly  1533 ISGLESVSCMSICKRLAKAIMVGTVGEKLYQC--DYRQLESRCQSSSSCHKPVLETSAIELPFAN 1595
            :..         |||:.           ..:|  :.:||...|..|.|          :.| |:
Frog  1205 LGD---------CKRVL-----------ALRCVPEAQQLAVLCGKSHS----------VRL-FS- 1237

  Fly  1596 RTPSEKWKLVLISD-------EAE--NALDSVAIAATSTRIVILKYDLKLHMF---------KPV 1642
                  |.|:|:.|       ||:  :|:.|..:...|:.::.:....:::.|         :.:
Frog  1238 ------WDLLLLPDSTGMKIPEAKGCHAIASGLVCQGSSPVLCVASKRQVYCFQLTSNKGSPRRI 1296

  Fly  1643 RALDTATPVT-------------SIFFTRHSAIVSSDKFYEIDLDNYAAEEFVDLSDKSMESTAK 1694
            :....|..|.             |..|:.| .|::.....::...|.....|:      |:||.
Frog  1297 KEFQAAGVVQCMDILGERLCVGYSSGFSLH-PILNEAAPIQLPHPNEPKLTFL------MQSTP- 1353

  Fly  1695 CQPLTAVRISRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTGFVYRDPFLFISHYQSVQIVR 1759
             ..|.|.|::..|:||||:.:||:||..|.:||..::.|...|...||..|.|.:....::.|..
Frog  1354 -DALCAARVTLSEFLLCFSTFGVYVDSQGRKSRTQEIMWPAPPVACVYTAPHLTVFSENALDIFD 1417

  Fly  1760 LHRS----------------------FSKE----------MASGD-----NASENS--------- 1778
            :.||                      |..|          :|..|     ..|:||
Frog  1418 VRRSEWIQTIPLKKVRSLNAEGSLCIFGSEKVRLVYLRNKLADQDEFNVPETSDNSRRQMVRTKS 1482

  Fly  1779 -----------ESPELQRVYL--PHYMSTLLANSGDVNLYAVAIDQRPCNGTQKIYHLDTMQAFK 1830
                       |..:.:||.:  |...|.|::|..:.| :.|.:.  |.:|..::..|...|..|
Frog  1483 KRHFSFRISDEERQQQRRVMMKDPELRSKLISNPKNFN-HLVHVG--PGDGKHQLKDLAVAQEEK 1544

  Fly  1831 -----QKFNISMETLSSVATSVTLGST 1852
                 |..:.|..:|||...:|...|:
Frog  1545 RRSSGQDVSASGSSLSSSIDNVKRNSS 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	146/355 (41%)
		S_TKc	113..383	CDD:214567	118/278 (42%)
		Smc	487..1222	CDD:224117	136/743 (18%)
		CNH	1503..1774	CDD:279162	67/340 (20%)
LOC100497498	XP_002938754.3	PKc_like	6..412	CDD:419665	170/462 (37%)
		SbcC	<438..909	CDD:223496	144/786 (18%)
		KELK	476..554	CDD:406277	27/109 (25%)
		C1_MRCKgamma	963..1014	CDD:410416	9/56 (16%)
		PH-like	1022..1149	CDD:418428	27/152 (18%)
		CNH	1178..1439	CDD:395630	63/307 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010