DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and rock1

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_021334267.1	Gene:	rock1 / 100329779	ZFINID:	ZDB-GENE-100712-2	Length:	1375	Species:	Danio rerio

Alignment Length:	1463	Identity:	375/1463 - (25%)
Similarity:	661/1463 - (45%)	Gaps:	311/1463 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLV 130
            |||:...|..:.|...|:| :::|.:|:.:::..|.:.|:||:.|:|:.:..:||:|.||.|.||
Zfish    32 LLDSLDALVYDLDFPALRK-NKSIDDFLKRYKDTISKIRELRMKAEDYEVVKVIGRGAFGEVQLV 95

  Fly   131 VERQTNDIYAMKKIKK-SVVTTSQVK---EERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPG 191
            ..:.|..:||||.:.| .::..|...   ||||||:..||.|::.|.|||||:..||:|||||||
Zfish    96 RHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQLFYAFQDDRYLYMVMEYMPG 160

  Fly   192 GDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAA 256
            |||::|||.: ...|..||||.||:.:||..:|.||::|||:||:|:|:|:.||:||||||....
Zfish   161 GDLVNLMSNY-DVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMK 224

  Fly   257 LDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFH 321
            :::||.|...:.|||||||:||:|::        ...|......||:||:|:..||::...|||:
Zfish   225 MNKDGMVRCDTAVGTPDYISPEVLKS--------QGGDGYYGRECDWWSVGVFLYEMLVGDTPFY 281

  Fly   322 EDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRL---SYERIKNHPFF 383
            .|::..|||||::|      |..::||.|..:|.:.::||.:.:|:...||   ..:.||.|.||
Zfish   282 ADSLVGTYSKIMNH------KNALTFPEDSDISKDAKSLICAFLTDREVRLGRNGVDEIKRHGFF 340

  Fly   384 --SEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPF 446
              .:..|.:||....|::|.:..|.|||||:|....:...|.....|:         |.|..|||
Zfish   341 KNDQWTWENIRETAAPVVPELSCDTDTSNFDDIEEDRGEEETFPIPKA---------FVGNQLPF 396

  Fly   447 IGYSF----VHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKTDNKSQ 507
            :|:::    :..::|.|..:......::.|.||:.|:.|..::    ::.:.::..||  |...|
Zfish   397 VGFTYYSNNLFSQESTIKTSDKRSSTKEDKSLLENLQKRIYQL----EEQVHSEMQLR--DEMEQ 455

  Fly   508 VVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQKYEEA 572
               ..:....||.:|:||                    :|||...:|.      :..|....|:.
Zfish   456 ---KCRASNTKLDKIMKE--------------------LDEESNLRKS------VEANMSILEKD 491

  Fly   573 KI-----ASE-QRYEKQLADKKQEL---ASTL--QKLDARELEFNAKFEECKHLSMKLQNYKDML 626
            ||     |:| ||...|.|:|::.|   .|||  |..|.|::..|.  ::...|..:|....|:|
Zfish   492 KIMIQHRATEYQRKADQEAEKRRNLENEVSTLKEQLEDLRKISQNN--DKIAQLQNQLGEANDLL 554

  Fly   627 QQIKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELD-ESISSS 690
            :...:..::...:|.|..:.|::| |....:|::|:|.::...:::..|:.:::|.|| |..|.|
Zfish   555 RAESDTVMRLRKSHTEMGKTMSQL-ESINRELQEKIRAAESVKQQLEKELLQLQTTLDTERRSCS 618

  Fly   691 KSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAECHRLERELQL 755
            :.::|.     |.::..:..|.|:   |..|.....|:||       |.:.|:..|:.||:|...
Zfish   619 QGSEEI-----RELQVRIMGLQED---NKNLKQSLTKVET-------ERKHVQERCNILEKEKNS 668

  Fly   756 AEC----RCQLAESSLATQVSPYETAPGSLTE-LNAIEDQLRADLLAAKE---SENHQKGRADQL 812
            .|.    :.:..:..|..:::.:......||: ..:||:...|.:.|.::   .|...:.||:..
Zfish   669 LEIDLNYKLKTLQQRLDQELTEHRITKAQLTDKYESIEESKSAAMHAVEQKVSEETTLRMRAESR 733

  Fly   813 QTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVE--RQA 875
            ...|.|...|||...:||:        :|.|      .|.:|.|:|||::..:|.|:..|  ::.
Zfish   734 VVEVEKQCSMLEFDLKQSV--------QKME------QLMKQKERLEDEVKDLRVQLEQETGKRV 784

  Fly   876 ARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQR----MLKTSQEETRQRE 936
            .....|..||::.:             |::.||.::|:..||:.|.:|    .|....::.|..|
Zfish   785 MSQNELKNWKMDSE-------------RLKGTEKQLKQEINAALENKRSVEFQLAQLTKQYRGNE 836

  Fly   937 SRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQE--TELRQKLRQIQ 999
            .::.||:.:|               :|||           :.:.:::.:.:|  .|:.:|.||.|
Zfish   837 GQMRELQDQL---------------EAEQ-----------YFSTLYKTQVKELKDEIEEKNRQTQ 875

  Fly  1000 SRFDGVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETM 1064
                    |....:::|..|:| |..|.....:.:.|.:||         |.::.:.|..|:...
Zfish   876 --------EALKRVQDLNSEKE-SLSAQLDLTMTKAESEQL---------ARALQEEQYVELSQE 922

  Fly  1065 LKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQV----LASEIDELR 1125
            .|....|.|.:.|:.|:...:|.:.|..||   |.:..:..||....:|.|.    .|:|.:||.
Zfish   923 YKKAVSRYKQEISEKDSTISQLEDSNKTLT---KDVEILSKEKTEFNERIQAQEQEFAAEREELT 984

  Fly  1126 LNLKEQQKKLVAQQDQLVEQTNALFATQERAELL---DGQNANYEAQTADSNREMVSLKEENARI 1187
            .::|...:|.:.     :|:|....|..:.||::   |.::......|.|..::    ::||.::
Zfish   985 NSIKANYEKALN-----IERTLKTQAVNKLAEIMNRKDMKDQKKRGSTTDLRKK----EKENRKL 1040

  Fly  1188 LSELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAE----KEQFYVQRDIKSNATLAQHK 1248
            ..||..:||:..::..:.:          .|::.:|...||    :.:..:|.|.|.:......:
Zfish  1041 QLELNQEKEKFNHMAFKYQ----------KELNEMQAQWAEECTYRNELQMQLDSKESDIEQLRE 1095

  Fly  1249 KLIDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILYRALKEELKREQKMNSL-- 1311
            ||.| |||:|::.|.                  .::.|::::|:|....|:..|....:.|..
Zfish  1096 KLND-LQLRVDNSSV------------------TSLQPDELDSNIAESRLEGWLAIPNRANIKRY 1141

  Fly  1312 -LKEQLAQLNGTATLRSPRKSAAVNGDSDAPKQRPVSIAALPR----SPQKQQQPLKRTTSQVEL 1371
             .|:|...:       |.:|....|.:.|..:..|..:..:.:    .|..|....:..|.::
Zfish  1142 GWKKQYVVV-------SSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETDEI-- 1197

  Fly  1372 KTTAEKPTKVTIENQAHHRFELALQESKVDAV-------------------------NCVVCEKA 1411
                .:..::...|:...|     :|:.|::|                         ||..|.|
Zfish  1198 ----PRIFQILYANEGECR-----KETDVESVPQGDKANCLPHKGHEFIPTLYHFPTNCEACSK- 1252

  Fly  1412 VVAGSPFW---------KCKECKDVTHRKCRSN 1435
                 |.|         :|:.|    |.||..:
Zfish  1253 -----PLWHVFKPPPALECRRC----HVKCHKD 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	140/353 (40%)
		S_TKc	113..383	CDD:214567	117/276 (42%)
		Smc	487..1222	CDD:224117	168/769 (22%)
		CNH	1503..1774	CDD:279162
rock1	XP_021334267.1	STKc_ROCK1	4..408	CDD:270772	154/400 (39%)
		SMC_N	<426..1105	CDD:330553	185/825 (22%)
		PH_ROCK	1124..1230	CDD:269948	18/123 (15%)
		C1	1234..1288	CDD:237996	11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920