DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and lats2

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_012811721.1	Gene:	lats2 / 100124721	XenbaseID:	XB-GENE-994907	Length:	1117	Species:	Xenopus tropicalis

Alignment Length:	522	Identity:	162/522 - (31%)
Similarity:	239/522 - (45%)	Gaps:	136/522 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NECDKDTLKKRDRNIAEFVNKF---------------------------------RPIIEETRKL 106
            |..|::..:.|.::.:.|..||                                 ..|.|:.||:
Frog   613 NSRDEEKRESRIKSYSPFAYKFYMEQHVENVLKTYQQKINRRLQLEQEMAEAGLCEAIQEQMRKI 677

  Fly   107 ------------RVNADDFL---IKTLIGQGYFGNVHLVVERQTNDIYAMKKI-KKSVVTTSQ-- 153
                        |...|..|   |||| |.|.||.|.|..:..|..:||||.: ||.|:..:|
Frog   678 LYQKESNYNRLKRAKMDKSLFVKIKTL-GIGAFGEVCLASKVDTKALYAMKTLRKKDVLNRNQVA 741

  Fly   154 -VKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAELT 217
             ||.||||::..::||::.|.|:|||.|:||.||:|:||||::||:.|...|.|.|||||:||||
Frog   742 HVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELT 806

  Fly   218 VALHTLHEMGYVHRDIKPENILIDRFGHIKLADFG---------NAAALDRDGHV---------- 263
            :|:.::|:||::||||||:|||||..|||||.|||         |:....:..|.
Frog   807 LAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHARQDSMEPSEL 871

  Fly   264 ---------------------------LSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSC 301
                                       |:.|.||||:|||||:|       |.|....:     |
Frog   872 WDDVSNCRCGDRLKTLEQRAKRQHHRCLAHSLVGTPNYIAPEVL-------LRKGYTQL-----C 924

  Fly   302 DYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVT 366
            |:||:|:|.:|::....||...|..||..|::      |.:..:..|:.:.:|....|||.:|..
Frog   925 DWWSVGVILFEMLVGQPPFLASNPTETQLKVI------HWENTLHIPSQINLSPEATNLITALCC 983

  Fly   367 NPSKRLSY---ERIKNHPFFSEIPWGS-IRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAK 427
            ....||..   :.||.||||..:.:.| ||.|..|.:|.:....|||||:.........:.|.:.
Frog   984 GAEDRLGRNGPDEIKAHPFFISMDFSSDIRHQPAPYVPKISHPMDTSNFDPVEEENPCNDSGDST 1048

  Fly   428 KSLTTNM----KSNDFSGKDLPF------IGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRE 482
            .:..|.|    |..:.:..:..|      .||.|.:.:.|.:..::.|:.:|:     .|..:||
Frog  1049 VTWDTLMSSGNKHTEHAFYEFTFRRFFDDHGYPFRYPKPSKLETSSCEETEEE-----DKNASRE 1108

  Fly   483 NE 484
            :|
Frog  1109 SE 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	143/407 (35%)
		S_TKc	113..383	CDD:214567	122/325 (38%)
		Smc	487..1222	CDD:224117
		CNH	1503..1774	CDD:279162
lats2	XP_012811721.1	UBA_LATS2	102..142	CDD:270581
lats2	XP_012811721.1	PKc_like	696..1075	CDD:419665	140/397 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920