DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10654 and ZNF160

DIOPT Version :9

Sequence 1:	NP_001261767.1	Gene:	CG10654 / 39428	FlyBaseID:	FBgn0036294	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	233	Identity:	66/233 - (28%)
Similarity:	92/233 - (39%)	Gaps:	59/233 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 HTLE----CRICHRGFYKPSLLEAHMQQHEGLRPYTCVHCAKSYARANLLESHLR---------- 274
            ||.|    |..|.|.|...|.|..|...|.|.:||.|..|.|.:...:.|.:|.|
Human   587 HTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEKPYKCHECGKVFRHNSYLATHRRIHTGEKPYKC 651

  Fly   275 -------QMHNNADAARII------YACPSCNKVYTANRSLKYHMR------------------- 307
                   .||:|....::|      |.|..|.||:|.|..|..|.|
Human   652 NECGKAFSMHSNLTTHKVIHTGEKPYKCNQCGKVFTQNSHLANHQRTHTGEKPYRCNECGKAFSV 716

  Fly   308 ----RTHERYHESESPDARHICEECGKCFARKAHLTRHKMVHGSVEGRR-YCCECCDRRFYTKEN 367
                .||:..|..:.|   :.|.||||.|.:.|||..|:.:|   .|.: |.|..|.:.|..:.:
Human   717 RSSLTTHQAIHTGKKP---YKCNECGKVFTQNAHLANHRRIH---TGEKPYRCTECGKAFRVRSS 775

  Fly   368 MVDHLLRKHGNKNLLLRCRKCGRIFQNSVELNAHGRKH 405
            :..|:....|.|.  .:|.:||::|:.|..|.:|.|.|
Human   776 LTTHMAIHTGEKR--YKCNECGKVFRQSSNLASHHRMH 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10654	NP_001261767.1	zf-AD	39..115	CDD:285071
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		C2H2 Zn finger	256..313	CDD:275368	22/102 (22%)
		C2H2 Zn finger	289..314	CDD:275368	11/47 (23%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
		C2H2 Zn finger	355..376	CDD:275368	4/20 (20%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523
		C2H2 Zn finger	259..279	CDD:275368
		zf-H2C2_2	271..295	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..350	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		zf-H2C2_2	355..380	CDD:290200
		COG5048	367..810	CDD:227381	64/230 (28%)
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		zf-H2C2_2	411..436	CDD:290200
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	496..519	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..576	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368	66/233 (28%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		zf-H2C2_2	607..632	CDD:290200	9/24 (38%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		zf-H2C2_2	635..659	CDD:290200	3/23 (13%)
		C2H2 Zn finger	651..671	CDD:275368	3/19 (16%)
		zf-H2C2_2	663..688	CDD:290200	7/24 (29%)
		C2H2 Zn finger	679..699	CDD:275368	9/19 (47%)
		zf-H2C2_2	691..715	CDD:290200	3/23 (13%)
		C2H2 Zn finger	707..727	CDD:275368	2/19 (11%)
		zf-H2C2_2	719..744	CDD:290200	10/27 (37%)
		C2H2 Zn finger	735..755	CDD:275368	10/19 (53%)
		zf-H2C2_2	747..770	CDD:290200	8/25 (32%)
		C2H2 Zn finger	763..783	CDD:275368	4/19 (21%)
		zf-H2C2_2	775..800	CDD:290200	7/26 (27%)
		C2H2 Zn finger	791..811	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142348
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930