DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10654 and ZNF347

DIOPT Version :9

Sequence 1:	NP_001261767.1	Gene:	CG10654 / 39428	FlyBaseID:	FBgn0036294	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001166145.1	Gene:	ZNF347 / 84671	HGNCID:	16447	Length:	840	Species:	Homo sapiens

Alignment Length:	397	Identity:	97/397 - (24%)
Similarity:	160/397 - (40%)	Gaps:	54/397 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DSTTTTTSGMDGCDGAKTMICRACLVLLGPQDACHNLDSE---QDLASKYYGCTGEDAVRDLPPQ 81
            :|........||.:..|.:|..              |.||   :||..|....|||.....:..:
Human    71 ESQVQIAGNPDGWEWIKAVITA--------------LSSEFVMKDLLHKGKSNTGEVFQTVMLER 121

  Fly    82 LVLKSICECCYQLVQK-FHDFQRMCAESLRNFEKLL--QDIDIGCHKLEDHTWHDLDTPSESNES 143
            ...:.|..|.::.||| .|..:..|.::..|::.:|  |:.:: .|..::|...|.......|:
Human   122 QESQDIEGCSFREVQKNTHGLEYQCRDAEGNYKGVLLTQEGNL-THGRDEHDKRDARNKLIKNQ- 184

  Fly   144 TNPEAQSHAPCIAATQEIVSFIWPQVCLPLAVILSRITLGASL---EEEVYVIEDESAKQDLGQE 205
            .....|||.|      |:..|.:.........:.......:|:   ::..|.::...:|:.|
Human   185 LGLSLQSHLP------ELQLFQYEGKIYECNQVEKSFNNNSSVSPPQQMPYNVKTHISKKYL--- 240

  Fly   206 KLSISSKLL-GARKRRGVRHTLECRICHRGFYKPSLLEAHMQQHEGLRPYTCVHCAKSYARANLL 269
            |..|||.|| ..:|........:...|...|.:.|.|.:|.:.|...:||.|..|.|::...:.|
Human   241 KDFISSLLLTQGQKANNWGSPYKSNGCGMVFPQNSHLASHQRSHTKEKPYKCYECGKAFRTRSNL 305

  Fly   270 ESHLRQMHNNADAARIIYACPSCNKVYTANRSLKYHMRRTHERYHESESPDARHICEECGKCFAR 334
            .:| :.:|.....    |.|..|.||::.|..|.     .|::.|..|.|   :.|.||||.|.:
Human   306 TTH-QVIHTGEKR----YKCNECGKVFSRNSQLS-----QHQKIHTGEKP---YKCNECGKVFTQ 357

  Fly   335 KAHLTRHKMVHGSVEGRR-YCCECCDRRFYTKENMVDHLLRKHGNKNLLLRCRKCGRIFQNSVEL 398
            .:||.||:.:|   .|.: |.|..|.:.|..:.::..|.....|.|.  .:|.:||::|..:..|
Human   358 NSHLVRHRGIH---TGEKPYKCNECGKAFRARSSLAIHQATHSGEKP--YKCNECGKVFTQNSHL 417

  Fly   399 NAHGRKH 405
            ..|.|.|
Human   418 TNHWRIH 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10654	NP_001261767.1	zf-AD	39..115	CDD:285071	18/79 (23%)
		C2H2 Zn finger	228..248	CDD:275368	5/19 (26%)
		C2H2 Zn finger	256..313	CDD:275368	14/56 (25%)
		C2H2 Zn finger	289..314	CDD:275368	7/24 (29%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
		C2H2 Zn finger	355..376	CDD:275368	4/20 (20%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	265..284	CDD:275368	5/18 (28%)
		COG5048	273..728	CDD:227381	50/170 (29%)
		zf-H2C2_2	276..301	CDD:290200	8/24 (33%)
		C2H2 Zn finger	292..312	CDD:275368	5/20 (25%)
		zf-H2C2_2	304..329	CDD:290200	8/29 (28%)
		C2H2 Zn finger	320..340	CDD:275368	7/24 (29%)
		zf-H2C2_2	333..357	CDD:290200	11/31 (35%)
		C2H2 Zn finger	348..368	CDD:275368	10/19 (53%)
		zf-H2C2_2	360..383	CDD:290200	9/25 (36%)
		C2H2 Zn finger	376..396	CDD:275368	4/19 (21%)
		zf-H2C2_2	388..413	CDD:290200	7/26 (27%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..439	CDD:290200	4/9 (44%)
		C2H2 Zn finger	432..452	CDD:275368
		zf-H2C2_2	444..469	CDD:290200
		zf-C2H2	458..480	CDD:278523
		C2H2 Zn finger	460..480	CDD:275368
		zf-H2C2_2	472..495	CDD:290200
		C2H2 Zn finger	488..508	CDD:275368
		zf-H2C2_2	500..525	CDD:290200
		C2H2 Zn finger	516..536	CDD:275368
		zf-H2C2_2	528..552	CDD:290200
		C2H2 Zn finger	544..564	CDD:275368
		zf-H2C2_2	556..581	CDD:290200
		C2H2 Zn finger	572..592	CDD:275368
		zf-H2C2_2	584..609	CDD:290200
		C2H2 Zn finger	600..620	CDD:275368
		C2H2 Zn finger	628..648	CDD:275368
		zf-H2C2_2	640..665	CDD:290200
		C2H2 Zn finger	656..676	CDD:275368
		zf-H2C2_2	668..693	CDD:290200
		C2H2 Zn finger	684..704	CDD:275368
		zf-H2C2_2	697..720	CDD:290200
		C2H2 Zn finger	712..732	CDD:275368
		COG5048	723..>817	CDD:227381
		zf-H2C2_2	724..749	CDD:290200
		C2H2 Zn finger	740..760	CDD:275368
		zf-H2C2_2	752..777	CDD:290200
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	795..813	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930