DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10654 and ZNF208

DIOPT Version :9

Sequence 1:	NP_001261767.1	Gene:	CG10654 / 39428	FlyBaseID:	FBgn0036294	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	484	Identity:	102/484 - (21%)
Similarity:	163/484 - (33%)	Gaps:	137/484 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CAGRIVADSTTTTTSGMDGCDGAKTMICRAC------LVLLGPQDACHNLDSEQDLASKYYGCTG 71
            |....:..||.||...:..  |.|...|:.|      ..:|......|               ||
Human   642 CGKTFIKVSTLTTHKAIHA--GEKPYKCKECGKAFSKFSILTKHKVIH---------------TG 689

  Fly    72 EDAVRDLPPQLVLKSICECCYQLV---------QKFHDFQR-----MCAESLRNFEKLLQD--ID 120
            |...:           ||.|.:..         ::.|..::     .|.:|...|..|.:.  |.
Human   690 EKPYK-----------CEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSVLTKHKVIH 743

  Fly   121 IG--CHKLED----HTW----------HDLDTPSESNESTNPEAQSHAPCIAATQEIVSFIWPQV 169
            .|  .:|.|:    :.|          |.::.|.:..|.  .:|.:.:..:...:.|.:...|..
Human   744 TGEKPYKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEEC--GKAFNRSAILIKHKRIHTDEKPYK 806

  Fly   170 CLPLAVILSRITLGASLEEEVYVIEDESAKQDLGQ--EKLSISSKLLGARKRRGVRHTLE----C 228
            |.......|:::. .:..:.::..|.....::.|:  .|.||.:|       ..|.||.|    |
Human   807 CEECGKTFSKVST-LTTHKAIHAGEKPYKCKECGKAFSKFSILTK-------HKVIHTGEKPYKC 863

  Fly   229 RICHRGFYKPSLLEAHMQQHEGLRPYTCVHCAKSYARANLLESH--------------------- 272
            ..|.:.:..||.|..|.:.|.|.:||.|..|.|.::..::|..|
Human   864 EECGKAYKWPSTLSYHKKIHTGEKPYKCEECGKGFSMFSILTKHEVIHTGEKPYKCEECGKAFSW 928

  Fly   273 --LRQMHNNADAARIIYACPSCNKVYTANRSLKYHMR-----------------------RTHER 312
              :...|....|....|.|.:|.|.|.::.:|.||.:                       ..|:.
Human   929 LSVFSKHKKTHAGEKFYKCEACGKAYKSSSTLSYHKKIHTEEKPYKYEECGKGFSTFSILTKHKV 993

  Fly   313 YHESESPDARHICEECGKCFARKAHLTRHKMVH-GSVEGRRYCCECCDRRFYTKENMVDHLLRKH 376
            .|..|.|   :.||||||.|...::|..||.:| |...   |.||.||:.|....::.:|.....
Human   994 IHTGEKP---YKCEECGKAFNWSSNLMEHKKIHTGETP---YKCEECDKAFSWPSSLTEHKATHA 1052

  Fly   377 GNKNLLLRCRKCGRIFQNSVELNAHGRKH 405
            |.|.  .:|.:||:.|.....|..|...|
Human  1053 GEKP--YKCEECGKAFSWPSRLTEHKATH 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10654	NP_001261767.1	zf-AD	39..115	CDD:285071	14/95 (15%)
		C2H2 Zn finger	228..248	CDD:275368	6/19 (32%)
		C2H2 Zn finger	256..313	CDD:275368	16/102 (16%)
		C2H2 Zn finger	289..314	CDD:275368	8/47 (17%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
		C2H2 Zn finger	355..376	CDD:275368	6/20 (30%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	384..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		zf-H2C2_2	511..536	CDD:290200
		C2H2 Zn finger	527..547	CDD:275368
		C2H2 Zn finger	555..575	CDD:275368
		zf-H2C2_2	568..592	CDD:290200
		C2H2 Zn finger	583..603	CDD:275368
		zf-H2C2_2	596..619	CDD:290200
		C2H2 Zn finger	611..631	CDD:275368
		C2H2 Zn finger	639..659	CDD:275368	5/16 (31%)
		C2H2 Zn finger	667..687	CDD:275368	3/19 (16%)
		COG5048	691..1133	CDD:227381	88/418 (21%)
		C2H2 Zn finger	695..715	CDD:275368	3/19 (16%)
		zf-H2C2_2	707..732	CDD:290200	3/24 (13%)
		C2H2 Zn finger	723..743	CDD:275368	4/19 (21%)
		C2H2 Zn finger	751..771	CDD:275368	2/19 (11%)
		zf-H2C2_2	764..788	CDD:290200	4/25 (16%)
		C2H2 Zn finger	779..799	CDD:275368	2/21 (10%)
		C2H2 Zn finger	807..827	CDD:275368	2/20 (10%)
		C2H2 Zn finger	835..855	CDD:275368	6/26 (23%)
		C2H2 Zn finger	863..883	CDD:275368	6/19 (32%)
		zf-H2C2_2	876..899	CDD:290200	9/22 (41%)
		C2H2 Zn finger	891..911	CDD:275368	5/19 (26%)
		C2H2 Zn finger	919..939	CDD:275368	1/19 (5%)
		C2H2 Zn finger	947..967	CDD:275368	7/19 (37%)
		C2H2 Zn finger	976..995	CDD:275368	1/18 (6%)
		C2H2 Zn finger	1003..1023	CDD:275368	10/19 (53%)
		zf-H2C2_2	1015..1039	CDD:290200	10/26 (38%)
		C2H2 Zn finger	1031..1051	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1059..1079	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1087..1107	CDD:275368
		zf-H2C2_2	1099..1124	CDD:290200
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840