DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10654 and ZNF99

DIOPT Version :9

Sequence 1:	NP_001261767.1	Gene:	CG10654 / 39428	FlyBaseID:	FBgn0036294	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	369	Identity:	94/369 - (25%)
Similarity:	147/369 - (39%)	Gaps:	121/369 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 CECCYQLVQKFHDFQR--------------MCAESLRNFEKLLQDIDIGCHKLEDHTWHDLDTPS 138
            ||.|.:..::|...::              .|:::..||..|.:      |::    .|..:.|.
Human   427 CEECGKAFKRFSALRKHKIIHTGKQPYKCEECSKAFSNFSALRK------HEI----IHTGEKPY 481

  Fly   139 ESNESTNPEAQSHAPCIAATQEIVSFIWPQVCLPLAVILSRITLGASLEEEVYVIEDESAK-QDL 202
            :..|           |..|      |.|.          |::|:     .:|..:|::..| ::.
Human   482 KCEE-----------CGKA------FKWS----------SKLTV-----HKVIHMEEKPCKCEEC 514

  Fly   203 GQEKLSISSKLLGARKRRGVRHT----LECRICHRGFYKPSLLEAHMQQHEGLRPYTCVHCAKSY 263
            |:     :.|...|.::..:.||    .:|..|.:.|...|.|..|...|.|.:||.|..|.|::
Human   515 GK-----AFKHFSALRKHKIIHTGKKPYKCEECGKAFNNSSTLMKHKIIHTGKKPYKCEECGKAF 574

  Fly   264 ARANLLESHLRQMH---------------NNADAAR---II------YACPSCNKVYTANRSLKY 304
            .:::.|..| :.:|               |:..|.|   ||      |.|..|.|.::.:.:|
Human   575 KQSSHLTRH-KAIHTGEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTL-- 636

  Fly   305 HMRRTHERYHESESPDARHICEECGKCFARKAHLTRHKMVHGSVEGRRYCCECCDRRFYTKENMV 369
               |.||..|..|.|   :.||||||.|...:||||||::|  .|.:.|.||.|.:.|
Human   637 ---RKHEIIHTGEKP---YKCEECGKAFKWSSHLTRHKVIH--TEEKPYKCEECGKAF------- 686

  Fly   370 DHL--LRKH-----GNKNLLLRCRKCGRIFQNSVELNAHGRKHK 406
            :|.  ||||     |.|.  .:|.:||:.|..|..|    |||:
Human   687 NHFSALRKHKIIHTGKKP--YKCEECGKAFSQSSTL----RKHE 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10654	NP_001261767.1	zf-AD	39..115	CDD:285071	7/40 (18%)
		C2H2 Zn finger	228..248	CDD:275368	6/19 (32%)
		C2H2 Zn finger	256..313	CDD:275368	19/80 (24%)
		C2H2 Zn finger	289..314	CDD:275368	7/24 (29%)
		zf-C2H2	323..345	CDD:278523	13/21 (62%)
		C2H2 Zn finger	325..345	CDD:275368	13/19 (68%)
		C2H2 Zn finger	355..376	CDD:275368	7/22 (32%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		COG5048	267..684	CDD:227381	77/314 (25%)
		zf-H2C2_2	272..296	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..352	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	383..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368	4/19 (21%)
		C2H2 Zn finger	455..475	CDD:275368	5/29 (17%)
		zf-H2C2_2	467..491	CDD:290200	7/50 (14%)
		C2H2 Zn finger	483..503	CDD:275368	8/51 (16%)
		C2H2 Zn finger	511..531	CDD:275368	3/24 (13%)
		zf-H2C2_2	523..548	CDD:290200	6/24 (25%)
		COG5048	534..857	CDD:227381	68/215 (32%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	552..576	CDD:290200	9/23 (39%)
		C2H2 Zn finger	567..587	CDD:275368	5/20 (25%)
		zf-H2C2_2	579..604	CDD:290200	3/25 (12%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		zf-H2C2_2	607..632	CDD:290200	8/24 (33%)
		C2H2 Zn finger	623..643	CDD:275368	7/24 (29%)
		zf-H2C2_2	636..659	CDD:290200	13/30 (43%)
		C2H2 Zn finger	651..671	CDD:275368	13/19 (68%)
		zf-H2C2_2	663..688	CDD:290200	13/33 (39%)
		C2H2 Zn finger	679..699	CDD:275368	9/26 (35%)
		zf-H2C2_2	691..716	CDD:290200	10/26 (38%)
		C2H2 Zn finger	707..727	CDD:275368	9/22 (41%)
		zf-H2C2_2	720..743	CDD:290200	4/9 (44%)
		C2H2 Zn finger	735..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	819..839	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930