DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10654 and CG1529

DIOPT Version :9

Sequence 1:	NP_001261767.1	Gene:	CG10654 / 39428	FlyBaseID:	FBgn0036294	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001138223.2	Gene:	CG1529 / 33077	FlyBaseID:	FBgn0031144	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	107/436 - (24%)
Similarity:	174/436 - (39%)	Gaps:	131/436 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ICRACLVLLGPQDACHNLDS----------EQDLASKYYGCTGEDAVRDLPPQLVLKSICECCYQ 93
            :||.||..|..:|. |..|.          :.|:..:.:|...|              ||..|:.
  Fly    11 LCRICLRHLRDRDT-HCPDPRLIAILQKLLDIDILKQPHGFPTE--------------ICNLCHN 60

  Fly    94 LVQKFHDFQRMCAESLRNFEKLL--QDIDIGCHKL----------EDHTWHDLDTPSESNESTNP 146
            .|..|.:.:::..||   .:||:  |.:||...::          |:|.    :...|..|....
  Fly    61 AVVYFDELRQVARES---SQKLIGWQPVDIAVDRVKEEPPDEGLKENHE----ENEHELEEEHEK 118

  Fly   147 EAQSHAPCIAATQEIVSFIWPQVCLPLAVILSRITLGASLEEEVYVIEDESAKQDLGQEKLSISS 211
            :|......::..||                 .:..:....|:|.|..|.|:::|.|.|.
  Fly   119 QADGQQVDLSKKQE-----------------DQKKILDDREDEEYPDEYENSQQQLSQG------ 160

  Fly   212 KLLGARKRRGVRHTLECRICHRGFYKPSLLEAHMQQ-HEGL-RPYTCVHCAKSYARANLLESHLR 274
              .|:::|.|    |.|..|.:..||...||||::. |:|. :|:.|..|.||:.|...|.||:|
  Fly   161 --TGSKRRAG----LACDQCGKQVYKLPYLEAHIRSVHQGYSKPFLCRSCDKSFTRYEQLRSHMR 219

  Fly   275 QMHNNADAAR-----IIYACPSCNKVYTANRSLKYHMRR-----------------------THE 311
            ..|...:..:     :|  |..||:.|:...:|..|::|                       ||.
  Fly   220 NAHPQLEQLQQELRDLI--CELCNRQYSTKNALGEHLKRHAQRKEHVCEHCGVAKVTRTELLTHL 282

  Fly   312 RYHESESPD-ARHICEECGKCFARKAHLTRH-KMVHGSVEG-RRYCCECCDRRFYTKENMVDHLL 373
            |.|   :|. .|..||:|.:.|..|:.::|| ::||   || ||:.|..|:::|.|..:.|.| .
  Fly   283 RTH---NPTWERFKCEQCPQLFRHKSAISRHVRVVH---EGQRRFQCGHCEKKFGTHASQVRH-E 340

  Fly   374 RKHGNKN-----------LLLRCRK-CGRIFQNSVELNAHGRKHKA 407
            |.|....           ..:.|:| |  :.:.::||  |.|:|:|
  Fly   341 RLHTESTGSGEAAEEWPFACIHCQKPC--VSRQTLEL--HLRRHRA 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10654	NP_001261767.1	zf-AD	39..115	CDD:285071	18/85 (21%)
		C2H2 Zn finger	228..248	CDD:275368	8/20 (40%)
		C2H2 Zn finger	256..313	CDD:275368	20/84 (24%)
		C2H2 Zn finger	289..314	CDD:275368	10/47 (21%)
		zf-C2H2	323..345	CDD:278523	7/22 (32%)
		C2H2 Zn finger	325..345	CDD:275368	7/20 (35%)
		C2H2 Zn finger	355..376	CDD:275368	7/20 (35%)
		C2H2 Zn finger	385..405	CDD:275368	7/20 (35%)
CG1529	NP_001138223.2	zf-AD	11..79	CDD:285071	18/85 (21%)
		C2H2 Zn finger	171..192	CDD:275368	8/20 (40%)
		zf-C2H2_2	201..>257	CDD:289522	17/57 (30%)
		C2H2 Zn finger	201..222	CDD:275368	9/20 (45%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	265..285	CDD:275368	3/19 (16%)
		zf-C2H2_8	268..349	CDD:292531	27/87 (31%)
		C2H2 Zn finger	294..315	CDD:275368	7/20 (35%)
		C2H2 Zn finger	323..343	CDD:275368	7/20 (35%)
		C2H2 Zn finger	360..380	CDD:275368	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100