DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10654 and LOC100365363

DIOPT Version :9

Sequence 1:	NP_001261767.1	Gene:	CG10654 / 39428	FlyBaseID:	FBgn0036294	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	XP_006228060.2	Gene:	LOC100365363 / 100365363	RGDID:	2319215	Length:	670	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	85/307 - (27%)
Similarity:	129/307 - (42%)	Gaps:	46/307 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LRNFEKL------LQDIDIGCHKLEDH--TWHDLDTPSESNESTNPEAQSHAPCIAATQEIVSFI 165
            |.|:..|      ||.:: ...|||.:  .|   ...||:..:.....|.:|  ||...|.:.
  Rat    38 LENYSNLVSLGMTLQSLN-AVSKLEQNKGPW---TVESEAIITRKSNVQEYA--IAMNAENID-- 94

  Fly   166 WPQVCLPLAVILSRITLGASL--EEEVYVIEDESAKQDLGQEKLSISSKLLGARKRRGVRHTLEC 228
                |:.    ...|:.|:|:  .:.:::..|   |.....|....||.|:..:|........:|
  Rat    95 ----CME----AKSISNGSSILSSDRIFLSGD---KAPFVHEYDVYSSLLMKGQKAAIKEKPYQC 148

  Fly   229 RICHRGFYKPSLLEAHMQQHEGLRPYTCVHCAKSYARANLLESHLRQMHNNADAARIIYACPSCN 293
            ..|.:.|...|.|..|.|.|.|.:.|.||.|.|::.|.:.|..|.|. |:.|..    |.|..|.
  Rat   149 NECDKVFRYTSSLAYHRQIHTGEKLYKCVECGKAFFRRSYLLVHERH-HSGAKP----YKCNECG 208

  Fly   294 KVYTANRSLKYHMRRTHERYHESESPDARHICEECGKCFARKAHLTRHKMVHGSVEGRRYCCECC 358
            ||::.|..||     :|.|.|..|.|   :.|.:|||.|:.:::||.|.::|  ...:.|.|..|
  Rat   209 KVFSQNSHLK-----SHRRIHTGEKP---YKCNDCGKAFSVRSNLTHHLVIH--TGDKPYKCNEC 263

  Fly   359 DRRFYTKENMVDHLLRKHGNKNLLLRCRKCGRIFQNSVELNAHGRKH 405
            .:.|....::..|.....|.|.  .||.:||::|.:...||.|...|
  Rat   264 GKVFSQTSSLTIHRRTHTGEKP--YRCNECGKVFSSHSNLNTHQAIH 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10654	NP_001261767.1	zf-AD	39..115	CDD:285071	2/5 (40%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		C2H2 Zn finger	256..313	CDD:275368	19/56 (34%)
		C2H2 Zn finger	289..314	CDD:275368	9/24 (38%)
		zf-C2H2	323..345	CDD:278523	8/21 (38%)
		C2H2 Zn finger	325..345	CDD:275368	8/19 (42%)
		C2H2 Zn finger	355..376	CDD:275368	4/20 (20%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
LOC100365363	XP_006228060.2	KRAB	8..68	CDD:214630	9/33 (27%)
		SFP1	<143..221	CDD:227516	28/87 (32%)
		C2H2 Zn finger	148..168	CDD:275368	7/19 (37%)
		C2H2 Zn finger	176..196	CDD:275368	8/20 (40%)
		COG5048	200..575	CDD:227381	38/125 (30%)
		C2H2 Zn finger	204..224	CDD:275368	9/24 (38%)
		C2H2 Zn finger	232..252	CDD:275368	8/19 (42%)
		C2H2 Zn finger	260..280	CDD:275368	4/19 (21%)
		C2H2 Zn finger	288..308	CDD:275368	7/19 (37%)
		C2H2 Zn finger	316..336	CDD:275368
		C2H2 Zn finger	344..364	CDD:275368
		C2H2 Zn finger	372..392	CDD:275368
		C2H2 Zn finger	400..420	CDD:275368
		C2H2 Zn finger	428..448	CDD:275368
		C2H2 Zn finger	456..476	CDD:275368
		C2H2 Zn finger	484..504	CDD:275368
		C2H2 Zn finger	512..532	CDD:275368
		C2H2 Zn finger	540..560	CDD:275368
		C2H2 Zn finger	568..588	CDD:275368
		zf-H2C2_2	580..604	CDD:404364
		C2H2 Zn finger	596..615	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335935
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930