DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10646 and DWA2

DIOPT Version :9

Sequence 1:	NP_648581.1	Gene:	CG10646 / 39426	FlyBaseID:	FBgn0036292	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_177753.1	Gene:	DWA2 / 843959	AraportID:	AT1G76260	Length:	350	Species:	Arabidopsis thaliana

Alignment Length:	373	Identity:	121/373 - (32%)
Similarity:	184/373 - (49%)	Gaps:	46/373 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YGLELQARALTPQYGESNDVCFFIATNSLKPTNQVHLIQYEEEQGSVQSK-VFEHALGEVWKLNS 71
            |||:.|||.::....:.:...|...|.|||..|:|||::.......:..: :|.|. .|:|.|.|
plant    10 YGLKYQARCISDVKADRDHTSFLTGTLSLKEENEVHLLRLSSGGSELLCEGLFSHP-NEIWDLAS 73

  Fly    72 CPRNPRLLASVYNVQKGAQVLTKAALFTLPENLNPDPEQLKSEYLPWEQVEVLDTEALGERVKTI 136
            .|.:.|:.::|::....    ..||::.:||...    |..|..|  |.|..||...  .::..:
plant    74 SPFDQRIFSTVFSTGDS----YGAAIWQIPEPYG----QSNSSTL--ECVASLDAHV--GKINCV 126

  Fly   137 EFHP--NQDTLACVVDNKVAVMQRAESSTRVVAEVPASGSSSGSAKHTQHFTSGKWSHHHQGHQF 199
            .:.|  |.|.|.. :|.:..|....:||.: .||| .|..|:| .:|:  .:.|.|:.|......
plant   127 LWCPSGNSDKLIS-MDEQNLVFWSLDSSKK-SAEV-LSKESAG-MRHS--LSGGAWNPHDVNSVA 185

  Fly   200 LTLQDGNLSAYDVRDTQHCAWSINDAHGQMVRDLDCNPNKQCHLVTGGDDGYLRIWDCRMPKAPV 264
            .| .:.::..:|:| |.....||..||   ||::|.|..::..||:..|:..:.:||.|..|.||
plant   186 AT-SESSIQFWDLR-TMKKNNSIERAH---VRNVDYNLKREHILVSADDESGIHLWDLRKTKFPV 245

  Fly   265 FERSDHSHWVWCVRFNTFHDQLILSSSSDCKVLLTCAGSVS----SETQVQAGLDESNFSGADAE 325
            .|...|:||.|.||.|..:::||||..:|..|.|..|.:.|    ||:.|:|
plant   246 QELPGHTHWTWAVRCNPEYEELILSVGTDSAVNLWFASASSEHKTSESPVEA------------- 297

  Fly   326 ERHKLLPDGLLQTFDQHEDSVYCAEWSNVDPWIFASLSYDGRVIISKV 373
            .|.::.|  ||.::..:|||||...||:.:|||||||||||||:|..|
plant   298 SRQRVNP--LLNSYTDYEDSVYGLAWSSREPWIFASLSYDGRVVIESV 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10646	NP_648581.1	WD40	<121..>382	CDD:225201	89/259 (34%)
		WD40 repeat	133..182	CDD:293791	14/50 (28%)
		WD40 repeat	190..223	CDD:293791	7/32 (22%)
		WD40	<204..370	CDD:295369	65/169 (38%)
		WD40 repeat	230..266	CDD:293791	13/35 (37%)
		WD40 repeat	274..340	CDD:293791	21/69 (30%)
		WD40 repeat	346..370	CDD:293791	17/23 (74%)
DWA2	NP_177753.1	WD40 repeat	19..63	CDD:293791	9/43 (21%)
		WD40	<51..>344	CDD:225201	106/332 (32%)
		WD40 repeat	69..118	CDD:293791	16/58 (28%)
		WD40 repeat	123..160	CDD:293791	11/39 (28%)
		WD40 repeat	168..204	CDD:293791	8/39 (21%)
		WD40 repeat	211..249	CDD:293791	14/37 (38%)
		WD40 repeat	255..296	CDD:293791	15/40 (38%)
		WD40 repeat	316..340	CDD:293791	17/23 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1007
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2481
Inparanoid	1	1.050	151	1.000	Inparanoid score	I1706
OMA	1	1.010	-	-		QHG54609
OrthoDB	1	1.010	-	-		D814890at2759
OrthoFinder	1	1.000	-	-		FOG0005856
OrthoInspector	1	1.000	-	-		otm3512
orthoMCL	1	0.900	-	-		OOG6_103789
Panther	1	1.100	-	-	O	PTHR14205
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4248
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840