DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10646 and AT1G20540

DIOPT Version :9

Sequence 1:	NP_648581.1	Gene:	CG10646 / 39426	FlyBaseID:	FBgn0036292	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_173478.2	Gene:	AT1G20540 / 838642	AraportID:	AT1G20540	Length:	351	Species:	Arabidopsis thaliana

Alignment Length:	380	Identity:	120/380 - (31%)
Similarity:	184/380 - (48%)	Gaps:	59/380 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YGLELQARALTPQYGESNDVCFFIATNSLKPTNQVHLIQYEEEQGS--VQSKVFEHALGEVWKLN 70
            |||:.|:|.::....:::...|...|.|||..|:|||::. ...||  :...:|.|. .|:|.|.
plant    10 YGLKYQSRCISDVKADTDYTSFLTGTLSLKEENEVHLLRL-SSGGSELICEGLFSHP-NEIWDLA 72

  Fly    71 SCPRNPRLLASVYNVQKGAQVLTKAALFTLPENLNPDPEQLKSEYLPWEQVEVLDTEALGERVKT 135
            |||.:.|:.::|::..:.    ..||::.:||...    ||.|..|              |||.:
plant    73 SCPFDQRIFSTVFSTGES----FGAAIWQIPELYG----QLNSPQL--------------ERVAS 115

  Fly   136 IEFHPNQDTLACVV-------DNKVAVMQR-----AESSTRVVAEVPASGSSSGSAKHTQHFTSG 188
            ::.|..:  :.||:       |..:::.::     :...::..|||    .|..||......:.|
plant   116 LDAHVGK--INCVLWWPSGRCDKLISIDEQNIFLWSLDCSKKSAEV----LSKDSAGMLHSLSGG 174

  Fly   189 KWSHHHQGHQFLTLQDGNLSAYDVRDTQHCAWSINDAHGQMVRDLDCNPNKQCHLVTGGDDGYLR 253
            .|..|.......| .:.::..:|:| |.....||..||   ||.:|.||.::..|||..|:..:.
plant   175 AWDPHDVNAVAAT-GESSVQFWDLR-TMKKVNSIEHAH---VRGVDYNPKREHILVTAEDESGIH 234

  Fly   254 IWDCRMPKAPVFERSDHSHWVWCVRFNTFHDQLILSSSSDCKVLLTCAGSVSSETQVQAGLDESN 318
            :||.|..|.||.|...|:||.|.||.|..:|.||||:.:|..|.|..|.:.||:.:......||.
plant   235 VWDLRKAKVPVQELPGHTHWTWAVRCNPEYDGLILSAGTDSVVNLWYASATSSDDKTSESPVEST 299

  Fly   319 FSGADAEERHKLLPDGLLQTFDQHEDSVYCAEWSNVDPWIFASLSYDGRVIISKV 373
                    |.::.|  ||.::..:|||||...||:.:||:||||||||||||..|
plant   300 --------RQRVNP--LLNSYTDYEDSVYGLAWSSREPWVFASLSYDGRVIIESV 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10646	NP_648581.1	WD40	<121..>382	CDD:225201	86/265 (32%)
		WD40 repeat	133..182	CDD:293791	11/60 (18%)
		WD40 repeat	190..223	CDD:293791	7/32 (22%)
		WD40	<204..370	CDD:295369	66/165 (40%)
		WD40 repeat	230..266	CDD:293791	15/35 (43%)
		WD40 repeat	274..340	CDD:293791	21/65 (32%)
		WD40 repeat	346..370	CDD:293791	16/23 (70%)
AT1G20540	NP_173478.2	WD40 repeat	19..63	CDD:293791	11/44 (25%)
		WD40	<51..>345	CDD:225201	106/338 (31%)
		WD40	64..341	CDD:295369	100/320 (31%)
		WD40 repeat	69..118	CDD:293791	18/70 (26%)
		WD40 repeat	123..161	CDD:293791	6/41 (15%)
		WD40 repeat	169..204	CDD:293791	7/36 (19%)
		WD40 repeat	211..249	CDD:293791	16/37 (43%)
		WD40 repeat	255..293	CDD:293791	15/37 (41%)
		WD40 repeat	317..341	CDD:293791	16/23 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1007
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2481
Inparanoid	1	1.050	151	1.000	Inparanoid score	I1706
OMA	1	1.010	-	-		QHG54609
OrthoDB	1	1.010	-	-		D814890at2759
OrthoFinder	1	1.000	-	-		FOG0005856
OrthoInspector	1	1.000	-	-		otm3512
orthoMCL	1	0.900	-	-		OOG6_103789
Panther	1	1.100	-	-	LDO	PTHR14205
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840