DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10646 and EIPR1

DIOPT Version :9

Sequence 1:	NP_648581.1	Gene:	CG10646 / 39426	FlyBaseID:	FBgn0036292	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	XP_011508685.1	Gene:	EIPR1 / 7260	HGNCID:	12383	Length:	426	Species:	Homo sapiens

Alignment Length:	421	Identity:	151/421 - (35%)
Similarity:	221/421 - (52%)	Gaps:	72/421 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QARALTPQYGESNDVCFFIATNSLKPTNQVHLIQYEEEQGSVQSKVFEHALGEVWKLNSCPRNPR 77
            :|||||||..|::.:.|.:.|.|||..||:|:|.:::|...:...|..|..||:|.:::.|.:..
Human    26 RARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQAGEIWHISASPADRG 90

  Fly    78 LLASVYN---------------------------VQKGAQVLTKAALFTLPENL------NPDPE 109
            :|.:.||                           ....::|||.||::.:|:.|      :||..
Human    91 VLTTCYNRTFCCVLSLDSFGALGKSAAQLFIALATSSDSKVLTCAAVWRMPKELESGSHESPDDS 155

  Fly   110 QLKSEYLPWEQVEVLDTEALGERVKTIEFHPNQDTLACVV--------------DNKVAVMQRAE 160
            ...::.|  |.:..||..|.|             .:||||              ||.:.:....|
Human   156 SSTAQTL--ELLCHLDNTAHG-------------NMACVVWEPMGDGKKIISLADNHILLWDLQE 205

  Fly   161 SSTRVVAEVPASGSSSGSAKHTQHFTSGKWSHHHQGHQFLTLQDGNLSAYDVRDTQHCAWSINDA 225
            ||::.|....||....|..|    ||||:||.||...|..|..|..|..:|.|.... .:.|.:|
Human   206 SSSQAVLASSASLEGKGQLK----FTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQ-IYCIENA 265

  Fly   226 HGQMVRDLDCNPNKQCHLVTGGDDGYLRIWDCRMPKAPVFERSDHSHWVWCVRFNTFHDQLILSS 290
            |||:|||||.|||||.:|.:.|||..::.||.|....||....:||||||.||:|..||||:|:.
Human   266 HGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTG 330

  Fly   291 SSDCKVLLTCAGSVSSETQVQAGLDESNFSGAD---AEERHK-LLPDGLLQTFDQHEDSVYCAEW 351
            |||.:|:|:...|:|||..... :|:.:.|..:   :||:.| .|.|.::.|:::||||||..:|
Human   331 SSDSRVILSNMVSISSEPFGHL-VDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDW 394

  Fly   352 SNVDPWIFASLSYDGRVIISKVPKQYKYQII 382
            |:.|||:|||||||||::|::||:..||.|:
Human   395 SSADPWLFASLSYDGRLVINRVPRALKYHIL 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10646	NP_648581.1	WD40	<121..>382	CDD:225201	112/278 (40%)
		WD40 repeat	133..182	CDD:293791	14/62 (23%)
		WD40 repeat	190..223	CDD:293791	10/32 (31%)
		WD40	<204..370	CDD:295369	79/169 (47%)
		WD40 repeat	230..266	CDD:293791	19/35 (54%)
		WD40 repeat	274..340	CDD:293791	27/69 (39%)
		WD40 repeat	346..370	CDD:293791	16/23 (70%)
EIPR1	XP_011508685.1	WD40 repeat	79..113	CDD:293791	5/33 (15%)
		WD40 repeat	121..169	CDD:293791	11/49 (22%)
		WD40 repeat	177..213	CDD:293791	10/35 (29%)
		WD40	178..413	CDD:392136	102/240 (43%)
		WD40 repeat	227..263	CDD:293791	13/36 (36%)
		WD40 repeat	270..308	CDD:293791	19/37 (51%)
		WD40 repeat	314..383	CDD:293791	27/69 (39%)
		WD40 repeat	389..413	CDD:293791	16/23 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142070
Domainoid	1	1.000	123	1.000	Domainoid score	I5615
eggNOG	1	0.900	-	-		E1_KOG1007
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2481
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2922
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54609
OrthoDB	1	1.010	-	-		D409006at33208
OrthoFinder	1	1.000	-	-		FOG0005856
OrthoInspector	1	1.000	-	-		oto91130
orthoMCL	1	0.900	-	-		OOG6_103789
Panther	1	1.100	-	-	LDO	PTHR14205
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4357
SonicParanoid	1	1.000	-	-		X4248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800