DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10646 and eipr1

DIOPT Version :9

Sequence 1:	NP_648581.1	Gene:	CG10646 / 39426	FlyBaseID:	FBgn0036292	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001011292.1	Gene:	eipr1 / 496745	XenbaseID:	XB-GENE-953865	Length:	387	Species:	Xenopus tropicalis

Alignment Length:	391	Identity:	154/391 - (39%)
Similarity:	230/391 - (58%)	Gaps:	17/391 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DENSLIYGLELQARALTPQYGESNDVCFFIATNSLKPTNQVHLIQYEEEQGSVQSKVFEHALGEV 66
            |:..:|||||.|||||..|..|::.:.|.:.|.||:..||:|:|.:::|...:...:..|..||:
Frog     3 DDAPVIYGLEFQARALAAQTAETDAIRFLVGTQSLRYDNQIHVIDFDDENNIINKNILLHHAGEI 67

  Fly    67 WKLNSCPRNPRLLASVYNVQKGAQVLTKAALFTLPENL----NPDPEQLKSEYLPWEQVEVLDTE 127
            |::::.|.:..:||:.||....::|||.||::.:|:.|    :..|:...|.....|.:..||..
Frog    68 WQISASPADRNVLATCYNKISDSKVLTCAAVWRIPKELQGGNHESPDDTSSNAQALELLCHLDNT 132

  Fly   128 ALGERVKTIEFHPNQD--TLACVVDNKVAVMQRAESSTRVVAEVPASGSSSGSAKHTQHFTSGKW 190
            |.| .:..:.:.|..|  .|..:.||.:.:....||||:.|    .|.|.:...|....||||||
Frog   133 AHG-NMACVTWEPLGDGKKLLSLADNYLMIWDLQESSTKSV----LSSSVTLEGKGQLRFTSGKW 192

  Fly   191 SHHHQGHQFLTLQDGNLSAYDVRDTQHCAWSINDAHGQMVRDLDCNPNKQCHLVTGGDDGYLRIW 255
            |.||...|..|..|..:..:|:|..:. .:.|.:||||:|||||.|||||.:|.:.|||..::.|
Frog   193 SPHHNCTQVATANDTAIRGWDIRSMRQ-IYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFW 256

  Fly   256 DCRMPKAPVFERSDHSHWVWCVRFNTFHDQLILSSSSDCKVLLTCAGSVSSETQVQAGLDESNFS 320
            |.|....||....:||||||.||:|..||||:|:.|||.:|:|:...|:|||..... :|:.:.|
Frog   257 DTRNIHEPVKTLEEHSHWVWSVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHL-VDDEDLS 320

  Fly   321 GAD---AEERHK-LLPDGLLQTFDQHEDSVYCAEWSNVDPWIFASLSYDGRVIISKVPKQYKYQI 381
            ..:   .||:.| .|.|.::.|:::||||||..|||:.|||:|||||||||::|::||:..||.|
Frog   321 DQEDNLQEEKTKEPLQDSVIATYEEHEDSVYAVEWSSADPWLFASLSYDGRLVINRVPRALKYNI 385

  Fly   382 I 382
            :
Frog   386 L 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10646	NP_648581.1	WD40	<121..>382	CDD:225201	112/266 (42%)
		WD40 repeat	133..182	CDD:293791	13/50 (26%)
		WD40 repeat	190..223	CDD:293791	9/32 (28%)
		WD40	<204..370	CDD:295369	79/169 (47%)
		WD40 repeat	230..266	CDD:293791	19/35 (54%)
		WD40 repeat	274..340	CDD:293791	27/69 (39%)
		WD40 repeat	346..370	CDD:293791	17/23 (74%)
eipr1	NP_001011292.1	WD40 repeat	68..125	CDD:293791	15/56 (27%)
		WD 1	132..172		11/40 (28%)
		WD40 repeat	138..180	CDD:293791	12/45 (27%)
		WD40	139..374	CDD:392136	103/240 (43%)
		WD 2	182..222		15/40 (38%)
		WD40 repeat	188..224	CDD:293791	13/36 (36%)
		WD 3	226..266		22/39 (56%)
		WD40 repeat	231..269	CDD:293791	19/37 (51%)
		WD 4	270..310		23/39 (59%)
		WD40 repeat	275..344	CDD:293791	27/69 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..333		4/21 (19%)
		WD 5	345..385		26/39 (67%)
		WD40 repeat	350..374	CDD:293791	17/23 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5819
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2481
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2882
OMA	1	1.010	-	-		QHG54609
OrthoDB	1	1.010	-	-		D409006at33208
OrthoFinder	1	1.000	-	-		FOG0005856
OrthoInspector	1	1.000	-	-		oto104910
Panther	1	1.100	-	-	LDO	PTHR14205
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4357
SonicParanoid	1	1.000	-	-		X4248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110