DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10646 and eipr1

DIOPT Version :9

Sequence 1:	NP_648581.1	Gene:	CG10646 / 39426	FlyBaseID:	FBgn0036292	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	XP_017207117.1	Gene:	eipr1 / 450045	ZFINID:	ZDB-GENE-041010-167	Length:	391	Species:	Danio rerio

Alignment Length:	406	Identity:	152/406 - (37%)
Similarity:	223/406 - (54%)	Gaps:	47/406 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DENSLIYGLELQARALTPQYGESNDVCFFIATNSLKPTNQVHLIQYEEEQGSVQSKVFEHALGEV 66
            |:..:|||||.||||||.|..|::.:.|.:.|.|||..||:|:|.:::|...:...|..|..||:
Zfish     7 DDAPVIYGLEFQARALTAQTAETDAIRFLVGTQSLKFDNQIHIIDFDDENNMINKSVLLHDAGEI 71

  Fly    67 WKLNSCPRNPRLLASVYNVQKGAQVLTKAALFTLPENLNPDPEQLKSEYLPWEQVEVLDTEALGE 131
            |.::..|.:..:|.:.||....::|||.||::.:|      ||        ||.......:....
Zfish    72 WHISGSPADKAVLTTCYNKTSESRVLTCAAVWRMP------PE--------WESGSHESPDDSSN 122

  Fly   132 RVKTIEFHPNQD-----TLACVV--------------DNKVAVMQRAESSTRVVAEVPASGSSSG 177
            ..:|:|...:.|     ::|||:              :|.|.:....|||.:......|:....|
Zfish   123 NPQTLELLCHLDNSAHGSMACVLWEPMGDGKRVISLAENHVLLWDLQESSAKATISSSATLEGKG 187

  Fly   178 SAKHTQHFTSGKWSHHHQGHQFLTLQDGNLSAYDVRDTQHCAWSINDAHGQMVRDLDCNPNKQCH 242
            ..|    ||:||||.||...|..|..|..:..:|:|.... .:.|.:||||:|||||.|||||.:
Zfish   188 QLK----FTAGKWSPHHNCTQLATANDTAIRGWDLRSMSQ-IYCIENAHGQLVRDLDFNPNKQYY 247

  Fly   243 LVTGGDDGYLRIWDCRMPKAPVFERSDHSHWVWCVRFNTFHDQLILSSSSDCKVLLTCAGSVSSE 307
            |.:.|||..::.||.|....||....:||||||.||:|..||||:|::|||.:|:|:...|:|||
Zfish   248 LASCGDDCKVKFWDVRHISEPVKCLEEHSHWVWSVRYNHSHDQLLLTASSDSRVILSNMVSISSE 312

  Fly   308 TQVQAGLDESNFSGADAEERH------KLLPDGLLQTFDQHEDSVYCAEWSNVDPWIFASLSYDG 366
            ..... :|:.:.|  |.||..      :.|.|.::.|:::||||||..|||..|||:||||||||
Zfish   313 PFGHL-VDDDDLS--DPEENQQEAKGKEPLQDSIISTYEEHEDSVYAVEWSAADPWLFASLSYDG 374

  Fly   367 RVIISKVPKQYKYQII 382
            |::|::||:..||:|:
Zfish   375 RLVINRVPRALKYRIL 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10646	NP_648581.1	WD40	<121..>382	CDD:225201	108/285 (38%)
		WD40 repeat	133..182	CDD:293791	14/67 (21%)
		WD40 repeat	190..223	CDD:293791	9/32 (28%)
		WD40	<204..370	CDD:295369	79/171 (46%)
		WD40 repeat	230..266	CDD:293791	19/35 (54%)
		WD40 repeat	274..340	CDD:293791	27/71 (38%)
		WD40 repeat	346..370	CDD:293791	17/23 (74%)
eipr1	XP_017207117.1	WD40 repeat	72..129	CDD:293791	16/70 (23%)
		WD40 repeat	142..184	CDD:293791	9/41 (22%)
		WD40	<143..303	CDD:330360	65/164 (40%)
		WD40 repeat	192..228	CDD:293791	12/36 (33%)
		WD40	231..>378	CDD:330360	74/149 (50%)
		WD40 repeat	235..273	CDD:293791	19/37 (51%)
		WD40 repeat	279..348	CDD:293791	27/71 (38%)
		WD40 repeat	354..378	CDD:293791	17/23 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575022
Domainoid	1	1.000	111	1.000	Domainoid score	I6235
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2481
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3033
OMA	1	1.010	-	-		QHG54609
OrthoDB	1	1.010	-	-		D409006at33208
OrthoFinder	1	1.000	-	-		FOG0005856
OrthoInspector	1	1.000	-	-		oto39635
orthoMCL	1	0.900	-	-		OOG6_103789
Panther	1	1.100	-	-	LDO	PTHR14205
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4357
SonicParanoid	1	1.000	-	-		X4248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940