DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10638 and AKR1D1

DIOPT Version :9

Sequence 1:	NP_001287050.1	Gene:	CG10638 / 39424	FlyBaseID:	FBgn0036290	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_005980.1	Gene:	AKR1D1 / 6718	HGNCID:	388	Length:	326	Species:	Homo sapiens

Alignment Length:	321	Identity:	138/321 - (42%)
Similarity:	191/321 - (59%)	Gaps:	14/321 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VKLNNGYEMPILGLGTYNSKDNEGEAA----VKHAIDVGYRHIDTAYFYQNEAEVGKAIRDKIAE 67
            :.|::|..:||:|||||:...:..:.|    ||.|||.||||||.||.||||.|||:|||:||||
Human    10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAE 74

  Fly    68 GVVKREDIFLVTKLWNIFHDPERVEGICRKQLSNFGLDYIDLYLMHMPVGYKYVDDNTLLPKNED 132
            |.|:|||||...|||...|.||.|.....:.|....|||:|||::.:|:.:|..|:  :.|::|:
Human    75 GKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDE--IYPRDEN 137

  Fly   133 DVLQLSDVDYLDTYKAMEKLVKLGLVRSIGVSNFNSEQLARVL--ANCEIKPVTNQVECSPALNQ 195
            ........:...|::|||.....|||:|:||||||..||..:|  ...:.|||:|||||.|...|
Human   138 GKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQ 202

  Fly   196 KALTAFCKKNDVTLTGYTPLGKPK----PDIQKPDFIYSPEVAVIAKKYGKTTPQIVLRYLVGLG 256
            ..|..||:::|:.:|.|:|||..:    .::..|..:....:..:.|:|.||..|||||:.:..|
Human   203 PKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRG 267

  Fly   257 VIPIPKSSNTNRISENFDIFDFELTAEEMAVLDGYHTGERVVPLNLIKGLNHKYYPFSIEF 317
            |:.||||.|..||.|||.||||.||.|||..::..:...|.|  .|:...:|..|||..|:
Human   268 VVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV--ELLMWRDHPEYPFHDEY 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10638	NP_001287050.1	ARA1	5..302	CDD:223729	132/304 (43%)
CG10638	NP_001287050.1	Tas	5..297	CDD:223739	130/299 (43%)
AKR1D1	NP_005980.1	AKR_AKR1D1-3	15..322	CDD:381335	134/310 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S990
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680