Protein Alignment CG10638 and AKR1C8

DIOPT Version :10

• Sequence 1: NP_729808.1
• Gene: CG10638 / 39424
• FlyBaseID: FBgn0036290
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_047281112.1
• Gene: AKR1C8 / 340811
• HGNCID: 23469
• Length: 398
• Species: Homo sapiens
• Alignment Length: 360
• Identity: 140/360 - (38%)
• Similarity: 191/360 - (53%)
• Gaps: 59/360 - (16%)

  Fly     1 MKLAPTVKLNNGYEMPILGLGTY---NSKDNEGEAAVKHAIDVGYRHIDTAYFYQNEAEVGKAIR 62
            :|.:.:|:||:|..||:||.|||   ::..::...|.|.|||||:||||:||.||||.|||:||.
Human     5 LKQSHSVRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKVAIDVGFRHIDSAYLYQNEEEVGQAIW 69

  Fly    63 DKIAEGVVKREDIFLVTKLWNIFHDPERVEGICRKQLSNFGLDYIDLYLMHMPV----------- 116
            :|||:|.||||:||...|||..|...|.|.....:.|...|.||:||:::|:|.
Human    70 EKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAMKVSFCFSLL 134

  Fly   117 -------GYKYVD----------------------------DNTLLPKNEDDVLQLSDVDYLDTY 146
                   |||:::                            ...||||:....:.|..|:..||:
Human   135 CPRLFHHGYKHLNYLILAWFPGFFLREADLSEVHRIAKTFPGKELLPKDASGEIILETVELCDTW 199

  Fly   147 KAMEKLVKLGLVRSIGVSNFNSEQLARVL--ANCEIKPVTNQVECSPALNQKALTAFCKKNDVTL 209
            :|:||..:.||.|||||||||.:.|..:|  ...:.||..|||||.|.|||..|..|||..|:.|
Human   200 EALEKCKEAGLTRSIGVSNFNHKLLELILNKPGLKYKPTCNQVECHPYLNQSKLLEFCKSKDIVL 264

  Fly   210 TGYTPLGKPK------PDIQKPDFIYSPEVAVIAKKYGKTTPQIVLRYLVGLGVIPIPKSSNTNR 268
            ..|:.||..:      ||.  |..:..|.:..||||:..:..|:.|||.:..||:.:.||.:..|
Human   265 VAYSALGSQRDPQWVDPDC--PHLLEEPILKSIAKKHSGSPGQVALRYQLQRGVVVLAKSFSQER 327

  Fly   269 ISENFDIFDFELTAEEMAVLDGYHTGERVVPLNLI 303
            |.|||.|||||||.|:|..:||.:...|...|.|:
Human   328 IKENFQIFDFELTPEDMKAIDGLNRNLRYDKLQLL 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10638	NP_729808.1	AKR_AKR2E1-5	5..298	CDD:381342	137/349 (39%)
AKR1C8	XP_047281112.1	AKR_AKR1C1-35	9..356	CDD:381334	136/348 (39%)