DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10638 and Akr1b8

DIOPT Version :9

Sequence 1:	NP_001287050.1	Gene:	CG10638 / 39424	FlyBaseID:	FBgn0036290	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_775159.1	Gene:	Akr1b8 / 286921	RGDID:	708475	Length:	316	Species:	Rattus norvegicus

Alignment Length:	322	Identity:	134/322 - (41%)
Similarity:	201/322 - (62%)	Gaps:	13/322 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAPTVKLNNGYEMPILGLGTYNSKDNEGEAAVKHAIDVGYRHIDTAYFYQNEAEVGKAIRDKIAE 67
            :|..|:|:...:|||:||||:.|..|:.:.|||.|||.||||||.||.|.||.|||:||::||.|
  Rat     1 MATFVELSTKAKMPIVGLGTWKSMPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQEKIKE 65

  Fly    68 GVVKREDIFLVTKLWNIFHDPERVEGICRKQLSNFGLDYIDLYLMHMPVGYKYVDDNTLLPKNED 132
            ..|:|||:|:|:|||....:.:.::...:|.|::..|||:||||:|.|.|::  ....|.||:|.
  Rat    66 KAVRREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGFQ--AGKELFPKDEQ 128

  Fly   133 DVLQLSDVDYLDTYKAMEKLVKLGLVRSIGVSNFNSEQLARVL--ANCEIKPVTNQVECSPALNQ 195
            ..:..|...:|:.::.||:||..|||:::||||||..|:.|:|  ...:.|||||||||.|.|.|
  Rat   129 GNVLPSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQ 193

  Fly   196 KALTAFCKKNDVTLTGYTPLGKP-----KPDIQKPDFIYSPEVAVIAKKYGKTTPQIVLRYLVGL 255
            :.|..:|....:.:|.|:|||.|     |||  .|..:..|::..||.|:.|||.|:::|:.:..
  Rat   194 EKLIQYCHSKGIVVTAYSPLGSPDRPRAKPD--DPSLLQDPKIKEIAAKHKKTTAQVLIRFHIQR 256

  Fly   256 GVIPIPKSSNTNRISENFDIFDFELTAEEMAVLDGYHTGERVVPLNLIKGLNHKYYPFSIEF 317
            .|:.||||....||.||..:|||:|:.:|||.:..::...|...|.  :.:|.:.:|:..|:
  Rat   257 NVVVIPKSVTPARIQENIQVFDFQLSDQEMATILSFNRNWRACLLP--ETVNMEEFPYDAEY 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10638	NP_001287050.1	ARA1	5..302	CDD:223729	130/303 (43%)
CG10638	NP_001287050.1	Tas	5..297	CDD:223739	128/298 (43%)
Akr1b8	NP_775159.1	ARA1	1..297	CDD:223729	129/299 (43%)
Akr1b8	NP_775159.1	Tas	16..289	CDD:223739	123/276 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730