Protein Alignment CG10638 and AKR7L

DIOPT Version :10

• Sequence 1: NP_729808.1
• Gene: CG10638 / 39424
• FlyBaseID: FBgn0036290
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001335350.1
• Gene: AKR7L / 246181
• HGNCID: 24056
• Length: 331
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 77/341 - (22%)
• Similarity: 122/341 - (35%)
• Gaps: 123/341 - (36%)

  Fly    27 DNEGEAAVKHA-IDVGYRHIDTAYFY---QNEAEV-GKAIRDKIAEGVVKREDIFLVTKL--W-- 82
            |....|||..| ::.|:..||||:.|   |:|..: |..:|...::..||     :.||.  |
Human    24 DAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVK-----IATKANPWIG 83

  Fly    83 NIFHDPERVEGICRKQLSNFGLDYIDLYLMHMPVGYKYVDDNTLLPKNEDDVLQLSDVDYLDTYK 147
            |.. .|:.|.......|.......:||:.:|.|       |:: .|..|             |.:
Human    84 NSL-KPDSVRSQLETSLKRLQCPRVDLFYLHAP-------DHS-APVEE-------------TLR 126

  Fly   148 AMEKLVKLGLVRSIGVSNFNSEQLARVLANCE----IKP---------VTNQVECS--PALNQKA 197
            |..:|.:.|....:|:||:.:.::|.:...|:    |.|         .|.|||..  |.|....
Human   127 ACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFG 191

  Fly   198 LTAFCKKNDVTLTGYTPL------GKPK---PDIQKP---------DFIYSPE---------VAV 235
            |..:         .|.||      ||.|   .|.::|         ..||...         :|:
Human   192 LRFY---------AYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIAL 247

  Fly   236 IAK----KYGKTTPQI---VLRYL-------------VGLGVIPIPKSSNTNRISENFDIFDFEL 280
            :.|    .||.:.|.:   .||::             |.||:      |:..::.:|.      .
Human   248 VEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGM------SSLEQLEQNL------A 300

  Fly   281 TAE----EMAVLDGYH 292
            .||    |.||:|.::
Human   301 AAEEGPLEPAVVDAFN 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10638	NP_729808.1	AKR_AKR2E1-5	5..298	CDD:381342	77/341 (23%)
AKR7L	NP_001335350.1	AKR_AKR7A1-5	10..319	CDD:381301	77/341 (23%)