Protein Alignment CG10638 and AKR1B1

DIOPT Version :10

• Sequence 1: NP_729808.1
• Gene: CG10638 / 39424
• FlyBaseID: FBgn0036290
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001619.1
• Gene: AKR1B1 / 231
• HGNCID: 381
• Length: 316
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 146/322 - (45%)
• Similarity: 205/322 - (63%)
• Gaps: 13/322 - (4%)

  Fly     3 LAPTVKLNNGYEMPILGLGTYNSKDNEGEAAVKHAIDVGYRHIDTAYFYQNEAEVGKAIRDKIAE 67
            :|..:.||||.:||||||||:.|...:...|||.||||||||||.|:.||||.|||.||::|:.|
Human     1 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLRE 65

  Fly    68 GVVKREDIFLVTKLWNIFHDPERVEGICRKQLSNFGLDYIDLYLMHMPVGYKYVDDNTLLPKNED 132
            .|||||::|:|:|||..:|:...|:|.|:|.||:..|||:||||:|.|.|:|  ......|.:|.
Human    66 QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK--PGKEFFPLDES 128

  Fly   133 DVLQLSDVDYLDTYKAMEKLVKLGLVRSIGVSNFNSEQLARVL--ANCEIKPVTNQVECSPALNQ 195
            ..:..||.:.|||:.|||:||..|||::||:||||..|:..:|  ...:.||..||:||.|.|.|
Human   129 GNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQ 193

  Fly   196 KALTAFCKKNDVTLTGYTPLGKP-----KPDIQKPDFIYSPEVAVIAKKYGKTTPQIVLRYLVGL 255
            :.|..:|:...:.:|.|:|||.|     ||  :.|..:..|.:..||.|:.|||.|:::|:.:..
Human   194 EKLIQYCQSKGIVVTAYSPLGSPDRPWAKP--EDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQR 256

  Fly   256 GVIPIPKSSNTNRISENFDIFDFELTAEEMAVLDGYHTGERVVPLNLIKGLNHKYYPFSIEF 317
            .::.||||....||:|||.:|||||::::|..|..|:...||..  |:...:||.|||..||
Human   257 NLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA--LLSCTSHKDYPFHEEF 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10638	NP_729808.1	AKR_AKR2E1-5	5..298	CDD:381342	136/299 (45%)
AKR1B1	NP_001619.1	AKR_AKR1B1-19	10..316	CDD:381333	140/311 (45%)