Protein Alignment CG10638 and AKR1C2

DIOPT Version :10

• Sequence 1: NP_729808.1
• Gene: CG10638 / 39424
• FlyBaseID: FBgn0036290
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001345.1
• Gene: AKR1C2 / 1646
• HGNCID: 385
• Length: 323
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 143/323 - (44%)
• Similarity: 193/323 - (59%)
• Gaps: 19/323 - (5%)

  Fly     7 VKLNNGYEMPILGLGTY------NSKDNEGEAAVKHAIDVGYRHIDTAYFYQNEAEVGKAIRDKI 65
            ||||:|:.||:||.|||      .||..|   |||.||:.|:.|||:|:.|.||.:||.|||.||
Human     8 VKLNDGHFMPVLGFGTYAPAEVPKSKALE---AVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKI 69

  Fly    66 AEGVVKREDIFLVTKLWNIFHDPERVEGICRKQLSNFGLDYIDLYLMHMPVGYKYVDDNTLLPKN 130
            |:|.|||||||..:|||:..|.||.|.....:.|.|..|||:||||:|.||..|..::  ::||:
Human    70 ADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEE--VIPKD 132

  Fly   131 EDDVLQLSDVDYLDTYKAMEKLVKLGLVRSIGVSNFNSEQLARVL--ANCEIKPVTNQVECSPAL 193
            |:..:....||...|::||||....||.:||||||||...|..:|  ...:.|||.|||||.|..
Human   133 ENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYF 197

  Fly   194 NQKALTAFCKKNDVTLTGYTPLG----KPKPDIQKPDFIYSPEVAVIAKKYGKTTPQIVLRYLVG 254
            ||:.|..|||..|:.|..|:.||    :|..|...|..:..|.:..:|||:.:|...|.|||.:.
Human   198 NQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262

  Fly   255 LGVIPIPKSSNTNRISENFDIFDFELTAEEMAVLDGYHTGERVVPLNLIKGLNHKYYPFSIEF 317
            .||:.:.||.|..||.:|..:|:|:||:|||..:||.:...|.:.|::..|..:  ||||.|:
Human   263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPN--YPFSDEY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10638	NP_729808.1	AKR_AKR2E1-5	5..298	CDD:381342	136/302 (45%)
AKR1C2	NP_001345.1	AKR_AKR1C1-35	6..308	CDD:381334	136/304 (45%)