DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10638 and Akr1b8

DIOPT Version :9

Sequence 1:	NP_001287050.1	Gene:	CG10638 / 39424	FlyBaseID:	FBgn0036290	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_032038.1	Gene:	Akr1b8 / 14187	MGIID:	107673	Length:	316	Species:	Mus musculus

Alignment Length:	322	Identity:	133/322 - (41%)
Similarity:	202/322 - (62%)	Gaps:	13/322 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAPTVKLNNGYEMPILGLGTYNSKDNEGEAAVKHAIDVGYRHIDTAYFYQNEAEVGKAIRDKIAE 67
            :|..|:|:...:|||:||||:.|..|:.:.|||.|||.||||||.||.|.||.|||:||::||.|
Mouse     1 MATFVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQEKIKE 65

  Fly    68 GVVKREDIFLVTKLWNIFHDPERVEGICRKQLSNFGLDYIDLYLMHMPVGYKYVDDNTLLPKNED 132
            ..|:|||:|:|:|||....:.:.::...:|.|::..|||:||||:|.|.|.:  ....|.||::.
Mouse    66 KAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQ--PGKELFPKDDQ 128

  Fly   133 DVLQLSDVDYLDTYKAMEKLVKLGLVRSIGVSNFNSEQLARVL--ANCEIKPVTNQVECSPALNQ 195
            ..:..|...:|:.::.||:||..|||:::||||||..|:.|:|  ...:.|||||||||.|.|.|
Mouse   129 GRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQ 193

  Fly   196 KALTAFCKKNDVTLTGYTPLGKP-----KPDIQKPDFIYSPEVAVIAKKYGKTTPQIVLRYLVGL 255
            :.|..:|....:::|.|:|||.|     ||  :.|..:..|::..||.|:.||:.|:::|:.:..
Mouse   194 EKLIQYCHSKGISVTAYSPLGSPDRPSAKP--EDPSLLEDPKIKEIAAKHEKTSAQVLIRFHIQR 256

  Fly   256 GVIPIPKSSNTNRISENFDIFDFELTAEEMAVLDGYHTGERVVPLNLIKGLNHKYYPFSIEF 317
            .|:.||||...:||.||..:|||:|:.||||.:..::...|...|.  :.:|.:.||:..|:
Mouse   257 NVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACLLP--ETVNMEEYPYDAEY 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10638	NP_001287050.1	ARA1	5..302	CDD:223729	128/303 (42%)
CG10638	NP_001287050.1	Tas	5..297	CDD:223739	126/298 (42%)
Akr1b8	NP_032038.1	ARA1	1..297	CDD:223729	127/299 (42%)
Akr1b8	NP_032038.1	Tas	16..289	CDD:223739	121/276 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730