DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10657 and SEC14L5

DIOPT Version :9

Sequence 1:	NP_648579.3	Gene:	CG10657 / 39423	FlyBaseID:	FBgn0036289	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens

Alignment Length:	301	Identity:	63/301 - (20%)
Similarity:	109/301 - (36%)	Gaps:	78/301 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LSPAMKLVAK--EELHED---------ENIRRQALAQFREWIEKHPHIRKCRTDTVFLLRFLRTK 84
            |.||::.|:.  ::|..|         ..::...|.|.|.|::: .|..|...|. .:|||||..
Human   212 LGPALEAVSMDGDKLDADYIERCLGHLTPMQESCLIQLRHWLQE-THKGKIPKDE-HILRFLRAH 274

  Fly    85 KFSVPSACEMLERYLTIRQLFPQWFKQLDIN-------DPAINEIFENG------------YLVP 130
            .|.:..|.|||.:.|:       |.||..::       .||:.|.|..|            |::.
Human   275 DFHLDKAREMLRQSLS-------WRKQHQVDLLLQTWQPPALLEEFYAGGWHYQDIDGRPLYILR 332

  Fly   131 LPQRDSTGRQVIFSVAAKFDPYKFTSVQMARVHSLV--------CEALLDDEDSQVAGYVYINDE 187
            |.|.|:.|..            |....:....|.|.        ||.........::.:..:.|.
Human   333 LGQMDTKGLM------------KAVGEEALLRHVLSVNEEGQKRCEGSTRQLGRPISSWTCLLDL 385

  Fly   188 SGMNMGFVSLW--SLTDLRSIVKCIQNSTPMRHKETHFVNIPHYANRIIELGVSMLSDKLKKRII 250
            .|:||.  .||  .:..|..:::.::::.|........|..|.....:..|....:::..:::.:
Human   386 EGLNMR--HLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRRKFL 448

  Fly   251 VHKN---------VDILKTKIDPAILPKE------YGGTVP 276
            ::..         ||.|..::.|..|..|      .||.||
Human   449 IYSGSNYQGPGGLVDYLDREVIPDFLGGESVCNVPEGGLVP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10657	NP_648579.3	CRAL_TRIO_N	52..98	CDD:215024	17/45 (38%)
CG10657	NP_648579.3	CRAL_TRIO	126..274	CDD:279044	29/184 (16%)
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		1/1 (100%)
		CRAL_TRIO_N	243..288	CDD:215024	17/46 (37%)
		SEC14	306..479	CDD:214706	32/186 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810