DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10657 and SEC14L1

DIOPT Version :9

Sequence 1:	NP_648579.3	Gene:	CG10657 / 39423	FlyBaseID:	FBgn0036289	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_001034662.3	Gene:	SEC14L1 / 6397	HGNCID:	10698	Length:	719	Species:	Homo sapiens

Alignment Length:	363	Identity:	71/363 - (19%)
Similarity:	128/363 - (35%)	Gaps:	115/363 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QPKLSGPAASSGGDYDYPYVCGLSPAMKLVAKEELHEDENIRRQALAQFREWIEKHPHIRKCRTD 73
            :|.:..|......||...|:..|:|               ::...|.:.|:|::: .|..|...|
Human   229 EPVVGTPDDKLDADYIKRYLGDLTP---------------LQESCLIRLRQWLQE-THKGKIPKD 277

  Fly    74 TVFLLRFLRTKKFSVPSACEMLERYLTIRQLFPQWFKQLDIN--------DPAINEIFENG---- 126
            . .:|||||.:.|::..|.|::.:.||       |.||..::        ...:.:.:..|
Human   278 E-HILRFLRARDFNIDKAREIMCQSLT-------WRKQHQVDYILETWTPPQVLQDYYAGGWHHH 334

  Fly   127 -------YLVPLPQRDSTGRQVIFSVAAKFDPYKFTSVQMARVHSLVCEALLD------------ 172
                   |::.|.|.|:.|                      .|.:|..||||.
Human   335 DKDGRPLYVLRLGQMDTKG----------------------LVRALGEEALLRYVLSINEEGLRR 377

  Fly   173 -DEDSQVAG-----YVYINDESGMNMGFVSLW--SLTDLRSIVKCIQNSTPMRHKETHFVNIPHY 229
             :|:::|.|     :..:.|..|:||.  .||  .:..|..|::.::.:.|........:..|..
Human   378 CEENTKVFGRPISSWTCLVDLEGLNMR--HLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRV 440

  Fly   230 ANRIIELGVSMLSDKLKKRIIVHKNVDI-----LKTKIDPAILPK----------EYGGTVPIAD 279
            ...:..|....:.|..:::.:::...|.     |...||..|:|.          ..||.||
Human   441 FPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCEVPEGGLVP--- 502

  Fly   280 MIAQFKQKLQQRRAAILALDDMQI---EVTKDAANFAG 314
                   |...|.|..|..:|:::   .:.:.|:.|.|
Human   503 -------KSLYRTAEELENEDLKLWTETIYQSASVFKG 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10657	NP_648579.3	CRAL_TRIO_N	52..98	CDD:215024	14/45 (31%)
CG10657	NP_648579.3	CRAL_TRIO	126..274	CDD:279044	34/193 (18%)
SEC14L1	NP_001034662.3	PRELI	17..173	CDD:368069
		CRAL_TRIO_N	256..301	CDD:215024	14/46 (30%)
		CRAL_TRIO	326..490	CDD:366224	33/187 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810