DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10657 and CLVS2

DIOPT Version :9

Sequence 1:	NP_648579.3	Gene:	CG10657 / 39423	FlyBaseID:	FBgn0036289	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens

Alignment Length:	252	Identity:	87/252 - (34%)
Similarity:	131/252 - (51%)	Gaps:	1/252 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GLSPAMKLVAKEELHEDENIRRQALAQFREWIEKHPHIRKCRTDTVFLLRFLRTKKFSVPSACEM 94
            ||||.....|:.||:|:.:...|.:.:.|:.:...|.|...|||..|:|||||.:||....|..:
Human     7 GLSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRL 71

  Fly    95 LERYLTIRQLFPQWFKQLDINDPAINEIFENGYLVPLPQRDSTGRQVIFSVAAKFDPYKFTSVQM 159
            |.:|...||.....||.....||.|.:..::|:...|...|..||:::...||.:|..::|.|.:
Human    72 LAQYFEYRQQNLDMFKSFKATDPGIKQALKDGFPGGLANLDHYGRKILVLFAANWDQSRYTLVDI 136

  Fly   160 ARVHSLVCEALLDDEDSQVAGYVYINDESGMNMGFVSLWSLTDLRSIVKCIQNSTPMRHKETHFV 224
            .|...|..||:::|.:.||.|:|.|.|.|.......|..:.:.||..::.:|:|.|.|....|||
Human   137 LRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFV 201

  Fly   225 NIPHYANRIIELGVSMLSDKLKKRIIVH-KNVDILKTKIDPAILPKEYGGTVPIADM 280
            |.|.|.:.:..:....|.:|.:|||.:| .|::.|...|.|.|||.|:||.:|..||
Human   202 NQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDM 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10657	NP_648579.3	CRAL_TRIO_N	52..98	CDD:215024	17/45 (38%)
CG10657	NP_648579.3	CRAL_TRIO	126..274	CDD:279044	50/148 (34%)
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	17/45 (38%)
		SEC14	106..251	CDD:238099	48/144 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4448
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.970