DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10663 and flz

DIOPT Version :9

Sequence 1:	NP_001097592.1	Gene:	CG10663 / 39421	FlyBaseID:	FBgn0036287	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster

Alignment Length:	973	Identity:	212/973 - (21%)
Similarity:	314/973 - (32%)	Gaps:	330/973 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ETQSGYVQ-------EAKREIWDAM-------------AHHRHRHHQHYHHGS-SHWIDGRRVHR 62
            ||.||||.       .|:|..:||:             |..|.|........: ...|.|....:
  Fly   794 ETTSGYVSPPTAVPAPAQRPQYDAVQGDASSERPVLVTASPRPRPKPSTKRPAVKRPISGESTKK 858

  Fly    63 LRMPHPQRWSGRRRSLNQH---QPFSRWSQWSPCDEECVRRRERFCKVKRKCGHTKHVEQSKCSH 124
            ...|.|...:..:..:::|   :|.|  :.:....|..:..    .::| |...|:|.||.:..:
  Fly   859 KPQPQPSAGAYNQEKISEHSTRKPVS--NGYDKVPESPITH----IQIK-KPSATQHKEQEQTGY 916

  Fly   125 CHP-----------------APAIKWQPPLILDDSHIRERIQPLPQPQPQPPPP--------PPP 164
            ..|                 ||::.:..|            ...|....||..|        |.|
  Fly   917 PRPASPAGYEQTTAAAPAPAAPSLNYDKP------------DAPPSQYDQPSAPSASYDQLAPMP 969

  Fly   165 SIIINAAAAAS----------------SGP-------TVDYRYTEYKP----------------- 189
            |:..|...|:|                :||       ||||.|....|
  Fly   970 SLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPATVDYHYDNVPPLFMADDKLDAFIQSTAE 1034

  Fly   190 ------PPNYASLYPSTHPPIY----TPTYPAAHPPTQPPTY-------------PPPTHPP--- 228
                  |.||       .||:.    ||.|  ||.||...:|             |.|..|.
  Fly  1035 NIVGSTPGNY-------QPPLVATASTPAY--AHRPTSSGSYGHKKPGFVQINGTPKPPRPTVLI 1090

  Fly   229 TPPPTP---------PTNPDEVVRHLPKY----PGKDIFSEEDVEDELEPEPDEDLISSDEQGDF 280
            ||.||.         ..:.:::......|    ||....|..|.:|               .|.|
  Fly  1091 TPKPTAINLVTYSSLSDDSNKLASSTSSYVTGRPGVQGVSSNDFKD---------------PGYF 1140

  Fly   281 FVLKHH----RHRRRQNHRRPSHRKPP-------------------------KEEDY-DDSDFVD 315
            .....|    :......:..||..||.                         .||.| ..:|||:
  Fly  1141 GSSPVHVAFTQSTTEAVYAVPSDDKPAFPGYFGPTPSYPAFSVPGEKVGQNVMEETYTSPNDFVN 1205

  Fly   316 FGERKSLRHRHLGEDSSVEGDV------FQYEDFDLPDTMY-----------------ADSQESE 357
            |...::.........|:|..|:      | .||..|.|.|:                 ||..|..
  Fly  1206 FPPVRNPNLNMSAASSAVTSDLDLSTPAF-VEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEP 1269

  Fly   358 GEFRNITWMQPAKDGIALRRRKVYSK--WSRWTKCSPKCTTRR----------YKKCRIMDQCGR 410
            |..:.:...|....|.|...|.|.::  ....|...||.||::          .||...:....|
  Fly  1270 GSNKTVATYQAGAGGTAKPVRVVTTRKPVRTATTTRPKVTTKKPVTRVTTKAPNKKTSAVSTTTR 1334

  Fly   411 EVLREIAYCYTEGSFCQQWLQTQFQKTPAFETRPGSGSPANAMRRMQSE---------------- 459
            :....              ..|...|......||.:..|.   ||:.|.
  Fly  1335 KPATR--------------RTTVAAKVTTTTRRPATKKPT---RRVSSTVKTTTVSSARPADDEI 1382

  Fly   460 ---------QPEVSMNDLNYIMTGKGYRGPE------------------YTPLKLSCGI---VRS 494
                     .|..|.|:::...|...|.|..                  ::| ...||:   |:|
  Fly  1383 VDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSP-STECGVRPHVKS 1446

  Fly   495 GTGRRSMSNMLKIIGGRAARKGEWPWQVAI-----LNRFKEAFCGGTLIAPRWVLTAAHC---VR 551
            |          :|:||:.:..|.:||||.:     |..|.:..|||.||..|:|:|||||   ..
  Fly  1447 G----------RIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQPGFL 1501

  Fly   552 KVLFVRIGEHNL--NYEDGTEIQLRVMKSYTHPNFDKRTVDSDVALLRLPKAVNATTWIGYSCLP 614
            ..|...:||.::  :.|....:...|.:...|..:|..|.::|:|||.|...|...|.|...|:|
  Fly  1502 ASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMP 1566

  Fly   615 QPFQALPKNVDCTIIGWGKRRNRDATGTSVLHKATVPIIPMQNCRKVY----YDYTITKNMFCAG 675
            .........: .|:.|||:.:..... .|||.:..||||....|::::    ::..|..:..|||
  Fly  1567 NDVADFTGRM-ATVTGWGRLKYGGGV-PSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAG 1629

  Fly   676 HQKGHIDTCAGDSGGPLLCRDTTKPNHPWTIFGITSFGDGCAQRNKFGIYAKVPNYVDWVWSV 738
            :..|..|:|.|||||||:.:   :|:..:.:.|..|.|..||.....|:|.:...|..|:.|:
  Fly  1630 YANGQKDSCEGDSGGPLVLQ---RPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSI 1689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10663	NP_001097592.1	Tryp_SPc	506..735	CDD:214473	75/242 (31%)
CG10663	NP_001097592.1	Tryp_SPc	507..735	CDD:238113	75/241 (31%)
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669	43/229 (19%)
		PHA03247	<792..1096	CDD:223021	68/329 (21%)
		Tryp_SPc	1449..1689	CDD:238113	76/244 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910