DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10663 and PRSS55

DIOPT Version :9

Sequence 1:	NP_001097592.1	Gene:	CG10663 / 39421	FlyBaseID:	FBgn0036287	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	297	Identity:	102/297 - (34%)
Similarity:	147/297 - (49%)	Gaps:	27/297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 PEVSMNDLNYIMTGKGYRG-----PEYTPLKLS-CGIVRSGTGRRSMSNMLKIIGGRAARKGEWP 519
            |...:.:....:.|:. ||     |.:.|..:| ||......||...|   :|.||..|..||:|
Human    20 PRTPLPEAGVAILGRA-RGAHRPQPPHPPSPVSECGDRSIFEGRTRYS---RITGGMEAEVGEFP 80

  Fly   520 WQVAILNRFKEAFCGGTLIAPRWVLTAAHCV------RKVLFVRIGEHNLNYEDGTEIQLRVMKS 578
            |||:|..| .|.||||:::...|:||||||:      .:.|.|.:|.::|. ....||: .|...
Human    81 WQVSIQAR-SEPFCGGSILNKWWILTAAHCLYSEELFPEELSVVLGTNDLT-SPSMEIK-EVASI 142

  Fly   579 YTHPNFDKRTVDSDVALLRLPKAVNATTWIGYSCLP-QPFQALPKNVDCTIIGWGKRRNRDATGT 642
            ..|.:|.:..:|:|:|||.|...:.........||| ||..|..:  :|.:.|||:....|....
Human   143 ILHKDFKRANMDNDIALLLLASPIKLDDLKVPICLPTQPGPATWR--ECWVAGWGQTNAADKNSV 205

  Fly   643 SV-LHKATVPIIPMQNCRKVYYDYTITKNMFCAGHQKGHIDTCAGDSGGPLLCRDTTKPNHPWTI 706
            .. |.||.:.|:..:.|.|::  ..:||||.|||::....|.|.|||||||:|  |.:|...|..
Human   206 KTDLMKAPMVIMDWEECSKMF--PKLTKNMLCAGYKNESYDACKGDSGGPLVC--TPEPGEKWYQ 266

  Fly   707 FGITSFGDGCAQRNKFGIYAKVPNYVDWVWSVVNCDG 743
            .||.|:|..|.::|..|||..:.||..|:..|...:|
Human   267 VGIISWGKSCGEKNTPGIYTSLVNYNLWIEKVTQLEG 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10663	NP_001097592.1	Tryp_SPc	506..735	CDD:214473	87/236 (37%)
CG10663	NP_001097592.1	Tryp_SPc	507..735	CDD:238113	87/235 (37%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	87/236 (37%)
		Tryp_SPc	68..298	CDD:238113	88/238 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910