Protein Alignment eyg and PAX8

DIOPT Version :9

• Sequence 1: NP_001014582.1
• Gene: eyg / 39419
• FlyBaseID: FBgn0000625
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_003457.1
• Gene: PAX8 / 7849
• HGNCID: 8622
• Length: 450
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 131/448 - (29%)
• Similarity: 185/448 - (41%)
• Gaps: 111/448 - (24%)

  Fly    88 IPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAVSKLL- 151
            |..|.||....||     ....|..|..::.| |:::.:. .|:|..||::.:....|.|||:|
Human     6 IRSGHGGLNQLGG-----AFVNGRPLPEVVRQ-RIVDLAH-QGVRPCDISRQLRVSHGCVSKILG 63

  Fly   152 -----GSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSS 211
                 ||:| ||:|||||||||||.||.||..|||:|||:||||||:||::||||.|.|.|||||
Human    64 RYYETGSIR-PGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSS 127

  Fly   212 INRILRNRAAER--------VATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPS 268
            ||||:|.:..:.        |||:..         .|.|..          :|.....||..|.|
Human   128 INRIIRTKVQQPFNLPMDSCVATKSL---------SPGHTL----------IPSSAVTPPESPQS 173

  Fly   269 ALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENR 333
                                      .||.|.:.:.|..|      ...|||......:|..::.
Human   174 --------------------------DSLGSTYSINGLLG------IAQPGSDKRKMDDSDQDSC 206

  Fly   334 HIDSDYLDDDDEPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSS--------------- 383
            .:..|.......|:.......||...||.||..|::.|||     |..:|
Human   207 RLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYP-----EAYASPSHTKGEQGLYPLPL 266

  Fly   384 -RTSLSEARVQVWFSNR--RAKWRRHQRMNLLKRQRSSPANPLH-SQQSNDAPASSPTPSNHSSA 444
             .::|.:.:..:..||.  ......||...::    :.|.:|.. .|::.:..:||.|||:.||:
Human   267 LNSTLDDGKATLTPSNTPLGRNLSTHQTYPVV----ADPHSPFAIKQETPEVSSSSSTPSSLSSS 327

  Fly   445 S--TSAPVAPVPPPQQPLPLCGDHSPQGPPPSVLL-HPLHGP--PGGHHHHHPLHLPT 497
            :  ....|....||....|.......|....::|. ..:.||  ||     :|.|:||
Human   328 AFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPG-----YPPHIPT 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_001014582.1	HTH	120..217	CDD:304362	59/102 (58%)
		Homeobox	352..404	CDD:278475	15/69 (22%)
PAX8	NP_003457.1	PAX	9..133	CDD:128645	67/131 (51%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		16/62 (26%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		34/47 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..222		16/104 (15%)
		Pax2_C	337..448	CDD:315141	13/49 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910