Protein Alignment eyg and PAX6

DIOPT Version :10

• Sequence 1: NP_524042.2
• Gene: eyg / 39419
• FlyBaseID: FBgn0000625
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001355839.1
• Gene: PAX6 / 5080
• HGNCID: 8620
• Length: 503
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 177/571 - (30%)
• Similarity: 236/571 - (41%)
• Gaps: 177/571 - (30%)

  Fly    29 EPHPQRITSLAPHASSVAAASVAAAAAAAAAAAAAAAGAGS----GAVAGGGGATSTSPTSVQIP 89
            |||.:  ....|.|.|.:..:.....::||....|.|||..    ....||.......|:
Human    17 EPHIR--APWNPAAPSQSQHAEQGGRSSAAEIKRAVAGANRLPALSLTCGGRTCLWLKPS----- 74

  Fly    90 PGFGGGGSTGGIPHGAGGPTGSTLNTL------------MSQHRLLEFSRFGGLRGYDIAQHMLT 142
            ||......|||  |       |.:|.|            .::.:::|.:. .|.|..||::.:..
Human    75 PGSDSHVCTGG--H-------SGVNQLGGVFVNGRPLPDSTRQKIVELAH-SGARPCDISRILQV 129

  Fly   143 QQGAVSKLL------GSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVC 201
            ..|.|||:|      ||:||.. ||||||:||||.|||||.|||||.|:|||||||:||:|||||
Human   130 SNGCVSKILGRYYETGSIRPRA-IGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVC 193

  Fly   202 TNATAPSVSSINRILRNRAAE-----------RVATEFARTAAYGLYPPPPHPYGSFTWHPAGNV 255
            ||...||||||||:|||.|:|           ::.....:|.::|..|         .|:|..:|
Human   194 TNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRP---------GWYPGTSV 249

  Fly   256 PGGQGVPPPPPPSALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGS 320
            ||                 .||........                     .||..||...|.|
Human   250 PG-----------------QPTQDGCQQQE---------------------GGGENTNSISSNG- 275

  Fly   321 GSHDTLESADENRHIDSDYLDDDDEP--------KFRRNRTTFSPEQLEELEKEFDKSHYPCVST 377
                                :|.||.        |.:||||:|:.||:|.|||||:::|||.|..
Human   276 --------------------EDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFA 320

  Fly   378 RERLSSRTSLSEARVQVWFSNRRAKWRRHQRMNLLKRQRSSPANPLHSQQSNDAPASSPTPSN-- 440
            ||||:::..|.|||:|||||||||||||.:::...:||.|:                  |||:
Human   321 RERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASN------------------TPSHIP 367

  Fly   441 -HSSASTSAPVAPVPPPQQPL--------------PLCGDHSPQGPPPSVLLH---PLHGPPGGH 487
             .||.|||. ..|:|.|..|:              .|...:|...|.||..:.   |:..|....
Human   368 ISSSFSTSV-YQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQ 431

  Fly   488 HHHHPLHLPTHPAALQLLSHYHQQQQQQQQQQHQQQQQQHHQQQQQLSPSG 538
            ...:...|||.|:.           ..:....:.....|.|...|.:..||
Human   432 TSSYSCMLPTSPSV-----------NGRSYDTYTPPHMQTHMNSQPMGTSG 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_524042.2	HTH_ARSR	120..217	CDD:481197	59/102 (58%)
		Homeodomain	349..405	CDD:459649	36/55 (65%)
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	64/134 (48%)
		Homeodomain	293..348	CDD:459649	36/54 (67%)