DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eyg and PAX5

DIOPT Version :9

Sequence 1:	NP_001014582.1	Gene:	eyg / 39419	FlyBaseID:	FBgn0000625	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_057953.1	Gene:	PAX5 / 5079	HGNCID:	8619	Length:	391	Species:	Homo sapiens

Alignment Length:	444	Identity:	129/444 - (29%)
Similarity:	187/444 - (42%)	Gaps:	136/444 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PTSVQIPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAV 147
            ||......|.||....||:     ...|..|..::.| |::|.:. .|:|..||::.:....|.|
Human     8 PTPRTSRTGHGGVNQLGGV-----FVNGRPLPDVVRQ-RIVELAH-QGVRPCDISRQLRVSHGCV 65

  Fly   148 SKLL------GSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATA 206
            ||:|      ||:: ||:|||||||||||.||.||.:|||:|||:||||||:||::|.||.|.|.
Human    66 SKILGRYYETGSIK-PGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTV 129

  Fly   207 PSVSSINRILRNRAAERVATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPSALW 271
            |||||||||:|.:..:                 ||:                     .|.|::..
Human   130 PSVSSINRIIRTKVQQ-----------------PPN---------------------QPVPASSH 156

  Fly   272 SVAAPTLANLPPSAASAVPVSTCG--SLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENRH 334
            |:.         |..|...||:..  |..|::.::|..|.|      ||         |||.|:.
Human   157 SIV---------STGSVTQVSSVSTDSAGSSYSISGILGIT------SP---------SADTNKR 197

  Fly   335 IDSDYLDDDDEPK--------FRRNR---TTFSPEQLEELEKEFDKSHYPCV-STRERL------ 381
            ...:.:.:...|.        |.|.:   ..|:.:|||.|::.|::.||..: :|.|.:
Human   198 KRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTT 262

  Fly   382 --SSRTSLSEARVQVWFSNRRAKWRRHQRMNLLKRQRSSPANPLHSQQSNDAPASSPTPSNHSSA 444
              |:..||:..                  ::.:|...:|| .|.....|...|.|.|..:....|
Human   263 EYSAMASLAGG------------------LDDMKANLASP-TPADIGSSVPGPQSYPIVTGRDLA 308

  Fly   445 STSAPVAP--VPPPQQPLPLCGDHSPQGPPPSVLLHPLHGPPG----GHHHHHP 492
            ||:.|..|  |||       .|..|...|..:.::      ||    |..:.||
Human   309 STTLPGYPPHVPP-------AGQGSYSAPTLTGMV------PGSEFSGSPYSHP 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_001014582.1	HTH	120..217	CDD:304362	58/102 (57%)
eyg	NP_001014582.1	Homeobox	352..404	CDD:278475	13/63 (21%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		5/12 (42%)
		PAX	16..140	CDD:128645	66/131 (50%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		17/62 (27%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		33/47 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		10/50 (20%)
		Pax2_C	279..389	CDD:403565	23/85 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810