Protein Alignment eyg and PAX3

DIOPT Version :10

• Sequence 1: NP_524042.2
• Gene: eyg / 39419
• FlyBaseID: FBgn0000625
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_852124.1
• Gene: PAX3 / 5077
• HGNCID: 8617
• Length: 505
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 168/562 - (29%)
• Similarity: 233/562 - (41%)
• Gaps: 177/562 - (31%)

  Fly    65 AGAGSGAVAGGGGAT---STSPTSVQIPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFS 126
            |||....:..|.|..   |..|..|..|.|.|.....||: ...|.|..:.:     :|:::|.:
Human     5 AGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGV-FINGRPLPNHI-----RHKIVEMA 63

  Fly   127 RFGGLRGYDIAQHMLTQQGAVSKLL------GSLRPPGLIGGSKPK-VATPTVVSKIEQYKRENP 184
            .. |:|...|::.:....|.|||:|      ||:| ||.||||||| |.||.|..|||:||||||
Human    64 HH-GIRPCVISRQLRVSHGCVSKILCRYQETGSIR-PGAIGGSKPKQVTTPDVEKKIEEYKRENP 126

  Fly   185 TIFAWEIRERLISEGVCTNATAPSVSSINRILRNR--AAERVATEFARTAAYGLYPPPPHPYGSF 247
            .:|:||||::|:.:.||...|.||||||:||||::  ..|....:..|..|........|
Human   127 GMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKH----- 186

  Fly   248 TWHPAGNVPGGQGVPPPPPPSALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPT 312
                                                        |..|.||
Human   187 --------------------------------------------SIDGILS-------------- 193

  Fly   313 NRAISPGSGSHDTLESADENRHIDSDYLDDDDEP---KFRRNRTTFSPEQLEELEKEFDKSHYPC 374
            .||.:|.|         ||...|||    :.|.|   |.||:||||:.|||||||:.|:::|||.
Human   194 ERASAPQS---------DEGSDIDS----EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPD 245

  Fly   375 VSTRERLSSRTSLSEARVQVWFSNRRAKWRRHQRMNLLKR----------QRSSPANPLHS-QQS 428
            :.|||.|:.|..|:|||||||||||||:||:....|.|..          ..:.|..|.:. .::
Human   246 IYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSET 310

  Fly   429 NDAPASSPTPSNHSSASTSAPVAPVPPP---QQPLPLCGDHSPQGPPPSVLLHPLHG-------- 482
            :..|.|.|...:..|::...| .|:||.   |..:|...|.|.....||.    .||
Human   311 SYQPTSIPQAVSDPSSTVHRP-QPLPPSTVHQSTIPSNPDSSSAYCLPST----RHGFSSYTDSF 370

  Fly   483 -PPGGHHHHHPLHLPT-----HPAALQLLSHY----HQQQQQQQQQQHQQQQQQHHQQQQQLSP- 536
             ||.|  ..:|:: ||     .|..:.||:::    ||.                 |....|||
Human   371 VPPSG--PSNPMN-PTIGNGLSPQVMGLLTNHGGVPHQP-----------------QTDYALSPL 415

  Fly   537 -----------SGCNPAANHLSMGGERSAFRSLVSSPSAAAF 567
                       :.|:...:|:         :||.|.|::.::
Human   416 TGGLEPTTTVSASCSQRLDHM---------KSLDSLPTSQSY 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_524042.2	HTH_ARSR	120..217	CDD:481197	52/103 (50%)
		Homeodomain	349..405	CDD:459649	37/55 (67%)
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		5/15 (33%)
		PAX	34..159	CDD:128645	58/132 (44%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	37..93		14/62 (23%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	113..161		29/47 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..228		26/138 (19%)
		Homeodomain	220..276	CDD:459649	37/55 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		11/42 (26%)
		Pax7	347..391	CDD:403540	12/50 (24%)