DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eyg and PAX3

DIOPT Version :9

Sequence 1:	NP_001014582.1	Gene:	eyg / 39419	FlyBaseID:	FBgn0000625	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_852124.1	Gene:	PAX3 / 5077	HGNCID:	8617	Length:	505	Species:	Homo sapiens

Alignment Length:	562	Identity:	168/562 - (29%)
Similarity:	233/562 - (41%)	Gaps:	177/562 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AGAGSGAVAGGGGAT---STSPTSVQIPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFS 126
            |||....:..|.|..   |..|..|..|.|.|.....||: ...|.|..:.:     :|:::|.:
Human     5 AGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGV-FINGRPLPNHI-----RHKIVEMA 63

  Fly   127 RFGGLRGYDIAQHMLTQQGAVSKLL------GSLRPPGLIGGSKPK-VATPTVVSKIEQYKRENP 184
            .. |:|...|::.:....|.|||:|      ||:| ||.||||||| |.||.|..|||:||||||
Human    64 HH-GIRPCVISRQLRVSHGCVSKILCRYQETGSIR-PGAIGGSKPKQVTTPDVEKKIEEYKRENP 126

  Fly   185 TIFAWEIRERLISEGVCTNATAPSVSSINRILRNR--AAERVATEFARTAAYGLYPPPPHPYGSF 247
            .:|:||||::|:.:.||...|.||||||:||||::  ..|....:..|..|........|
Human   127 GMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKH----- 186

  Fly   248 TWHPAGNVPGGQGVPPPPPPSALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPT 312
                                                        |..|.||
Human   187 --------------------------------------------SIDGILS-------------- 193

  Fly   313 NRAISPGSGSHDTLESADENRHIDSDYLDDDDEP---KFRRNRTTFSPEQLEELEKEFDKSHYPC 374
            .||.:|.|         ||...|||    :.|.|   |.||:||||:.|||||||:.|:::|||.
Human   194 ERASAPQS---------DEGSDIDS----EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPD 245

  Fly   375 VSTRERLSSRTSLSEARVQVWFSNRRAKWRRHQRMNLLKR----------QRSSPANPLHS-QQS 428
            :.|||.|:.|..|:|||||||||||||:||:....|.|..          ..:.|..|.:. .::
Human   246 IYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSET 310

  Fly   429 NDAPASSPTPSNHSSASTSAPVAPVPPP---QQPLPLCGDHSPQGPPPSVLLHPLHG-------- 482
            :..|.|.|...:..|::...| .|:||.   |..:|...|.|.....||.    .||
Human   311 SYQPTSIPQAVSDPSSTVHRP-QPLPPSTVHQSTIPSNPDSSSAYCLPST----RHGFSSYTDSF 370

  Fly   483 -PPGGHHHHHPLHLPT-----HPAALQLLSHY----HQQQQQQQQQQHQQQQQQHHQQQQQLSP- 536
             ||.|  ..:|:: ||     .|..:.||:::    ||.                 |....|||
Human   371 VPPSG--PSNPMN-PTIGNGLSPQVMGLLTNHGGVPHQP-----------------QTDYALSPL 415

  Fly   537 -----------SGCNPAANHLSMGGERSAFRSLVSSPSAAAF 567
                       :.|:...:|:         :||.|.|::.::
Human   416 TGGLEPTTTVSASCSQRLDHM---------KSLDSLPTSQSY 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_001014582.1	HTH	120..217	CDD:304362	52/103 (50%)
eyg	NP_001014582.1	Homeobox	352..404	CDD:278475	34/51 (67%)
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		5/15 (33%)
		PAX	34..159	CDD:128645	58/132 (44%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	37..93		14/62 (23%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	113..161		29/47 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..228		26/138 (19%)
		Homeobox	222..276	CDD:395001	35/53 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		11/42 (26%)
		Pax7	347..391	CDD:403540	12/50 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810