DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eyg and Gsc

DIOPT Version :9

Sequence 1:	NP_001014582.1	Gene:	eyg / 39419	FlyBaseID:	FBgn0000625	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001137762.2	Gene:	Gsc / 33240	FlyBaseID:	FBgn0010323	Length:	473	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	127/486 - (26%)
Similarity:	182/486 - (37%)	Gaps:	107/486 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GGGGATSTSP-TSVQIPPGFG---------GGGSTGGIPHGAGG-----------PTGSTLNTLM 117
            ||||.|:|:| |:..|||...         ...|....|..||.           |.|.||....
  Fly    11 GGGGTTTTTPSTTPDIPPSKAKFKITVVSTPSPSPPPTPPPAGSMLAQMVETNSPPAGYTLKRSP 75

  Fly   118 S-----QHRLLEFSRF-GGLRGYDIAQHML--TQQ-GAVSKLLGSLRPPGLIGGSKPKVATPTV- 172
            |     |....:.||. |....|.:...||  :|| |.:.:.|.|:.........:.:..||:.
  Fly    76 SDLGEQQQPPRQISRSPGNTAAYHLTTAMLLNSQQCGYLGQRLQSVLQQQHAQHQQSQSQTPSSD 140

  Fly   173 ------VSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSS---------------INRIL 216
                  |:.:|:.:|......:....:.::........||||..|               |:..|
  Fly   141 DGSQSGVTILEEERRGGAAAASLFTIDSILGSRQQGGGTAPSQGSHISSNGNQNGLTSNGISLGL 205

  Fly   217 RNRAAERVATEFARTAAYGLYPP------P---PHPYGSFTWHPAGNVPGGQGVPPPPPPSALWS 272
            :...||..|:..:.:::.....|      |   .|| |....|.|.....|....|..     :.
  Fly   206 KRSGAESPASPNSNSSSSAAASPIRPQRVPAMLQHP-GLHLGHLAAAAASGFAASPSD-----FL 264

  Fly   273 VAAPTLANLPPSAASAVPVS-TCGSLSSAHLMAGGAGGT--------PTNRAISPGSGSHDTLES 328
            ||.|   |..|:...|..|: ...:...||:....||.:        |......|..|:|.
  Fly   265 VAYP---NFYPNYMHAAAVAHVAAAQMQAHVSGAAAGLSGHGHHPHHPHGHPHHPHLGAHH---- 322

  Fly   329 ADENRHIDSDYLDDDDEPK-FRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARV 392
             ....|:  .:|.....|| .||:||.|:.||||:||..|||:|||.|..||:|:.:..|.|.||
  Fly   323 -HGQHHL--SHLGHGPPPKRKRRHRTIFTEEQLEQLEATFDKTHYPDVVLREQLALKVDLKEERV 384

  Fly   393 QVWFSNRRAKWRRHQRMNLLKRQRSSPANPLHSQQSNDAPASSPTPSNHSSASTSAPVAPVPPPQ 457
            :|||.|||||||:.      ||:.......|..:|.......:...|:.:::||......|..|.
  Fly   385 EVWFKNRRAKWRKQ------KREEQERLRKLQEEQCGSTTNGTTNSSSGTTSSTGNGSLTVKCPG 443

  Fly   458 QPLPLCGDH-SPQGPPPSVLLHPLHGPPGGH 487
                  .|| |.|      |:| :...|.|:
  Fly   444 ------SDHYSAQ------LVH-IKSDPNGY 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_001014582.1	HTH	120..217	CDD:304362	22/122 (18%)
eyg	NP_001014582.1	Homeobox	352..404	CDD:278475	31/51 (61%)
Gsc	NP_001137762.2	Homeobox	343..396	CDD:278475	31/52 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450828
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840