DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eyg and Pax8

DIOPT Version :9

Sequence 1:	NP_001014582.1	Gene:	eyg / 39419	FlyBaseID:	FBgn0000625	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_035170.1	Gene:	Pax8 / 18510	MGIID:	97492	Length:	457	Species:	Mus musculus

Alignment Length:	459	Identity:	134/459 - (29%)
Similarity:	192/459 - (41%)	Gaps:	126/459 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 IPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAVSKLL- 151
            |..|.||....||     ....|..|..::.| |:::.:. .|:|..||::.:....|.|||:|
Mouse     6 IRSGHGGLNQLGG-----AFVNGRPLPEVVRQ-RIVDLAH-QGVRPCDISRQLRVSHGCVSKILG 63

  Fly   152 -----GSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSS 211
                 ||:| ||:|||||||||||.||.||..|||:|||:||||||:||::||||.|.|.|||||
Mouse    64 RYYETGSIR-PGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSS 127

  Fly   212 INRILRNRAAER--------VATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPS 268
            ||||:|.:..:.        |||:..         .|.|..          :|.....||..|.|
Mouse   128 INRIIRTKVQQPFNLPMDSCVATKSL---------SPGHTL----------IPSSAVTPPESPQS 173

  Fly   269 ALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENR 333
                                      .||.|.:.:.|..|      ...||:.:...::.:|:
Mouse   174 --------------------------DSLGSTYSINGLLG------IAQPGNDNKRKMDDSDQ-- 204

  Fly   334 HIDSDYLDDDDE-----PKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSS---------- 383
              ||..|..|.:     |:......|||...||.||..|::.|||     |..:|
Mouse   205 --DSCRLSIDSQSSSSGPRKHLRTDTFSQHHLEALECPFERQHYP-----EAYASPSHTKGEQGL 262

  Fly   384 ------RTSLSEARVQVWFSNR--RAKWRRHQRMNLLKRQRSSPANPLH-SQQSNDAPASSPTPS 439
                  .::|.:.:..:..||.  ......||...::    :.|.:|.. .|::.:..:||.|||
Mouse   263 YPLPLLNSALDDGKATLTSSNTPLGRNLSTHQTYPVV----ADPHSPFAIKQETPELSSSSSTPS 323

  Fly   440 NHSSAS--------TSAPVAPVPPPQQPLPLCGDHSPQGPPPSVLL-HPLHGP--PGGHHHHHPL 493
            :.||::        :..|.....||....|.......|....::|. ..:.||  ||     :|.
Mouse   324 SLSSSAFLDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPG-----YPP 383

  Fly   494 HLPT 497
            |:||
Mouse   384 HIPT 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_001014582.1	HTH	120..217	CDD:304362	59/102 (58%)
eyg	NP_001014582.1	Homeobox	352..404	CDD:278475	16/69 (23%)
Pax8	NP_035170.1	PAX	9..133	CDD:128645	67/131 (51%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	12..68		16/62 (26%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	87..135		34/47 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..224		18/110 (16%)
		Pax2_C	344..455	CDD:372091	13/49 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810