Protein Alignment eyg and Pax8

DIOPT Version :10

• Sequence 1: NP_524042.2
• Gene: eyg / 39419
• FlyBaseID: FBgn0000625
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Alignment Length: 459
• Identity: 134/459 - (29%)
• Similarity: 192/459 - (41%)
• Gaps: 126/459 - (27%)

  Fly    88 IPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAVSKLL- 151
            |..|.||....||     ....|..|..::.| |:::.:. .|:|..||::.:....|.|||:|
Mouse     6 IRSGHGGLNQLGG-----AFVNGRPLPEVVRQ-RIVDLAH-QGVRPCDISRQLRVSHGCVSKILG 63

  Fly   152 -----GSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSS 211
                 ||:| ||:|||||||||||.||.||..|||:|||:||||||:||::||||.|.|.|||||
Mouse    64 RYYETGSIR-PGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSS 127

  Fly   212 INRILRNRAAER--------VATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPS 268
            ||||:|.:..:.        |||:..         .|.|..          :|.....||..|.|
Mouse   128 INRIIRTKVQQPFNLPMDSCVATKSL---------SPGHTL----------IPSSAVTPPESPQS 173

  Fly   269 ALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENR 333
                                      .||.|.:.:.|..|      ...||:.:...::.:|:
Mouse   174 --------------------------DSLGSTYSINGLLG------IAQPGNDNKRKMDDSDQ-- 204

  Fly   334 HIDSDYLDDDDE-----PKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSS---------- 383
              ||..|..|.:     |:......|||...||.||..|::.|||     |..:|
Mouse   205 --DSCRLSIDSQSSSSGPRKHLRTDTFSQHHLEALECPFERQHYP-----EAYASPSHTKGEQGL 262

  Fly   384 ------RTSLSEARVQVWFSNR--RAKWRRHQRMNLLKRQRSSPANPLH-SQQSNDAPASSPTPS 439
                  .::|.:.:..:..||.  ......||...::    :.|.:|.. .|::.:..:||.|||
Mouse   263 YPLPLLNSALDDGKATLTSSNTPLGRNLSTHQTYPVV----ADPHSPFAIKQETPELSSSSSTPS 323

  Fly   440 NHSSAS--------TSAPVAPVPPPQQPLPLCGDHSPQGPPPSVLL-HPLHGP--PGGHHHHHPL 493
            :.||::        :..|.....||....|.......|....::|. ..:.||  ||     :|.
Mouse   324 SLSSSAFLDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPG-----YPP 383

  Fly   494 HLPT 497
            |:||
Mouse   384 HIPT 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_524042.2	HTH_ARSR	120..217	CDD:481197	59/102 (58%)
		Homeodomain	349..405	CDD:459649	16/73 (22%)
Pax8	NP_035170.1	PAX	9..133	CDD:128645	67/131 (51%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		16/62 (26%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		34/47 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		18/110 (16%)
		Pax2_C	344..456	CDD:463563	13/49 (27%)