DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eyg and Pax2

DIOPT Version :9

Sequence 1:	NP_001014582.1	Gene:	eyg / 39419	FlyBaseID:	FBgn0000625	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001355672.1	Gene:	Pax2 / 18504	MGIID:	97486	Length:	432	Species:	Mus musculus

Alignment Length:	461	Identity:	140/461 - (30%)
Similarity:	199/461 - (43%)	Gaps:	131/461 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAVSKLL--- 151
            ||.||....||:     ...|..|..::.| |::|.:. .|:|..||::.:....|.|||:|
Mouse    15 PGHGGVNQLGGV-----FVNGRPLPDVVRQ-RIVELAH-QGVRPCDISRQLRVSHGCVSKILGRY 72

  Fly   152 ---GSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSIN 213
               ||:: ||:|||||||||||.||.||.:|||:|||:||||||:||::||:|.|.|.|||||||
Mouse    73 YETGSIK-PGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSIN 136

  Fly   214 RILRNRAAERVATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPSALWSVAAPTL 278
            ||:|.:..:                 |.||           .|.|.|.....|...:    .|:.
Mouse   137 RIIRTKVQQ-----------------PFHP-----------TPDGAGTGVTAPGHTI----VPST 169

  Fly   279 ANLPPSAASAVPVSTCGSLS-------------------------SAHLMAGGAGGTP---TNRA 315
            |:.|.|:||..||   ||.|                         .||:.  |.||..   |.|.
Mouse   170 ASPPVSSASNDPV---GSYSINGILGIPRSNGEKRKREEVEVYTDPAHIR--GGGGLHLVWTLRD 229

  Fly   316 ISPGSGSHDTLESADEN--RHIDSDYLDDDDEPKFRRNRTTFSPEQLEELEKEFDKSHYPCV-ST 377
            :|.||..:...:|..::  :|:.:|               ||:.:|||.|::.|::..||.| ..
Mouse   230 VSEGSVPNGDSQSGVDSLRKHLRAD---------------TFTQQQLEALDRVFERPSYPDVFQA 279

  Fly   378 RERLSSRTSLSEARVQVWFSNRRAKWRRHQRMNLLKRQRSSPANP-LHSQQSNDAPASSPTPSNH 441
            .|.:.|..           .|..:.......::.:|...|:.||| |.|..|  ...:.|..:..
Mouse   280 SEHIKSEQ-----------GNEYSLPALTPGLDEVKSSLSASANPELGSNVS--GTQTYPVVTGR 331

  Fly   442 SSASTSAPVAP--VPPPQQPLPLCGDHSPQGPPPSVLLHPLHGPP-GGHHHHHPLHLP------- 496
            ...||:.|..|  |||..|     |.:     |.|.|...:.|.. .|:.:.||.:..
Mouse   332 DMTSTTLPGYPPHVPPTGQ-----GSY-----PTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRF 386

  Fly   497 THPAAL 502
            ::||.|
Mouse   387 SNPALL 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eyg	NP_001014582.1	HTH	120..217	CDD:304362	58/102 (57%)
eyg	NP_001014582.1	Homeobox	352..404	CDD:278475	13/52 (25%)
Pax2	NP_001355672.1	PAX	16..140	CDD:128645	66/131 (50%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		17/62 (27%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		33/47 (70%)
		homeodomain	255..>278	CDD:381795	10/22 (45%)
		Pax2_C	305..>390	CDD:372091	24/96 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810